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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:renovascular hypertension
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Accession:DOID:1591 term browser browse the term
Definition:Hypertension due to RENAL ARTERY OBSTRUCTION or compression.
Synonyms:exact_synonym: Goldblatt Hypertension;   Goldblatt Syndrome;   renal vascular hypertension
 primary_id: MESH:D006978
 xref: EFO:1001153;   ICD10CM:I15.0;   NCI:C85044
For additional species annotation, visit the Alliance of Genome Resources.

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renovascular hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin ISO protein:increased expression:plasma RGD PMID:15284680 RGD:1625303 NCBI chrNW_004955414:25,951,473...25,953,593
Ensembl chrNW_004955414:25,951,349...25,953,645 		JBrowse link
G Adrb1 adrenoceptor beta 1 ISO RGD PMID:15592645 PMID:17278011 RGD:7241568 RGD:7241580 NCBI chrNW_004955431:19,025,663...19,027,026 JBrowse link
G Agtr1 angiotensin II receptor type 1 ISO mRNA:decreased expression:kidney: RGD PMID:9644212 PMID:16796846 PMID:21326341 RGD:10047119 RGD:5129177 RGD:5147455 NCBI chrNW_004955474:8,733,942...8,781,305
Ensembl chrNW_004955474:8,733,942...8,781,255 		JBrowse link
G Agtr2 angiotensin II receptor type 2 ISO RGD PMID:18158356 PMID:21189405 RGD:6903867 RGD:6903868 NCBI chrNW_004955534:3,653,112...3,654,248
Ensembl chrNW_004955534:3,653,157...3,654,248 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A ISO mRNA:altered expression:brain RGD PMID:15613739 RGD:2300323 NCBI chrNW_004955458:10,245,325...10,253,209
Ensembl chrNW_004955458:10,245,111...10,253,209 		JBrowse link
G Camk2d calcium/calmodulin dependent protein kinase II delta treatment ISO RGD PMID:26619200 RGD:401940196 NCBI chrNW_004955428:25,583,501...25,880,395 JBrowse link
G Ccnd2 cyclin D2 ISO protein:increased expression:left ventricle: RGD PMID:26300251 RGD:151664604 NCBI chrNW_004955413:2,083,351...2,108,450
Ensembl chrNW_004955413:2,083,351...2,103,430 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:17062848 RGD:2311383 NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:17062848 RGD:2311383 NCBI chrNW_004955475:11,148,928...11,152,313
Ensembl chrNW_004955475:11,148,879...11,152,596 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A treatment ISO RGD PMID:26619200 RGD:401940196 NCBI chrNW_004955407:36,456,628...36,588,940
Ensembl chrNW_004955407:36,453,098...36,589,382 		JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4 gamma 2 ISO mRNA:increased expression:heart left ventricle RGD PMID:12708758 RGD:10755511 NCBI chrNW_004955414:26,389,125...26,399,916
Ensembl chrNW_004955414:26,389,125...26,399,916 		JBrowse link
G Fn1 fibronectin 1 ISO RGD PMID:17324142 RGD:7205461 NCBI chrNW_004955457:629,599...694,948
Ensembl chrNW_004955457:629,518...696,975 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase treatment ISO RGD PMID:22684021 RGD:10449172 NCBI chrNW_004955580:1,045,294...1,058,129
Ensembl chrNW_004955580:1,045,294...1,057,083 		JBrowse link
G Gja1 gap junction protein alpha 1 ISO RGD PMID:11422751 RGD:7207851 NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095 		JBrowse link
G Gja5 gap junction protein alpha 5 ISO RGD PMID:11422751 RGD:7207851 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:urine: RGD PMID:22923545 RGD:7245500 NCBI chrNW_004955408:11,047,679...11,070,492 JBrowse link
G Hdac8 histone deacetylase 8 treatment ISO RGD PMID:27673327 RGD:13208809 NCBI chrNW_004955475:11,748,502...12,012,884
Ensembl chrNW_004955475:11,748,365...12,013,241 		JBrowse link
G Lama2 laminin subunit alpha 2 ISO mRNA:decreased expression:heart RGD PMID:10773239 RGD:1600206 NCBI chrNW_004955436:9,829,777...10,400,101
Ensembl chrNW_004955436:9,830,030...10,399,891 		JBrowse link
G Mpo myeloperoxidase ISO protein:increased activity:heart, brain, kidney RGD PMID:19549002 RGD:7174698 NCBI chrNW_004955451:4,743,744...4,753,358
Ensembl chrNW_004955451:4,743,744...4,753,358 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO RGD PMID:16788145 RGD:1642130 NCBI chrNW_004955455:13,797,557...13,978,402
Ensembl chrNW_004955455:13,797,545...13,972,566 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO CTD Direct Evidence: therapeutic CTD PMID:18641695 NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814 		JBrowse link
G Pdgfa platelet derived growth factor subunit A ISO mRNA:increased expression:vascular associated smooth muscle cell RGD PMID:17439406 RGD:2289672 NCBI chrNW_004955460:8,328,400...8,346,755
Ensembl chrNW_004955460:8,326,891...8,346,550 		JBrowse link
G Prl prolactin ISO protein:increased expression:plasma RGD PMID:17316702 RGD:1642574 NCBI chrNW_004955483:4,495,257...4,503,377 JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO protein:increased expression:kidney (rat) RGD PMID:16788145 RGD:1642130 NCBI chrNW_004955423:21,096,926...21,164,435 JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO RGD PMID:17766473 RGD:2300258 NCBI chrNW_004955419:5,678,750...5,699,305
Ensembl chrNW_004955419:5,678,694...5,699,305 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:nucleus, kidney RGD PMID:18032469 RGD:2298840 NCBI chrNW_004955422:19,602,930...19,612,263
Ensembl chrNW_004955422:19,603,345...19,611,516 		JBrowse link
G Ren renin ISO mRNA:increased expression:renal cortex (mouse)
protein:increased activity:blood plasma (human)		 RGD PMID:2240003 PMID:22378822 RGD:125097504 RGD:6892688 NCBI chrNW_004955406:40,016,624...40,026,286
Ensembl chrNW_004955406:40,016,630...40,026,286 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 treatment ISO RGD PMID:12218313 RGD:727424 NCBI chrNW_004955452:6,409,833...6,467,841
Ensembl chrNW_004955452:6,409,833...6,467,841 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 treatment ISO RGD PMID:12218313 RGD:727424 NCBI chrNW_004955504:226,192...260,632
Ensembl chrNW_004955504:228,049...260,650 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:12620700 RGD:1581326 NCBI chrNW_004955474:1,914,477...1,922,025
Ensembl chrNW_004955474:1,913,829...1,922,016 		JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 treatment ISO RGD PMID:26619200 RGD:401940196 NCBI chrNW_004955451:4,992,634...4,996,619
Ensembl chrNW_004955451:4,992,634...4,999,029 		JBrowse link
G Trip11 thyroid hormone receptor interactor 11 ISO ClinVar Annotator: match by term: Goldblatt syndrome ClinVar PMID:20089971 PMID:23956106 PMID:25741868 PMID:28492532 PMID:29872333 More... NCBI chrNW_004955438:14,327,400...14,394,022
Ensembl chrNW_004955438:14,322,576...14,394,022 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13822
      Urogenital Diseases 4397
        urinary system disease 2231
          kidney disease 2022
            renal hypertension 69
              renovascular hypertension 32
Path 2
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13822
      cardiovascular system disease 4076
        vascular disease 2852
          artery disease 1888
            hypertension 938
              secondary hypertension 69
                renal hypertension 69
                  renovascular hypertension 32
paths to the root