RGD Reference Report - Effect of celecoxib on the antihypertensive effect of losartan in a rat model of renovascular hypertension. - Rat Genome Database

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Effect of celecoxib on the antihypertensive effect of losartan in a rat model of renovascular hypertension.

Authors: Boshra, V  El Wakeel, GA  Nader, MA 
Citation: Boshra V, etal., Can J Physiol Pharmacol. 2011 Feb;89(2):103-7.
RGD ID: 5129177
Pubmed: PMID:21326341   (View Abstract at PubMed)
DOI: DOI:10.1139/y10-112   (Journal Full-text)

Certain nonsteroidal anti-inflammatory drugs have been reported to elevate blood pressure in some hypertensive patients, who are either untreated or treated with antihypertensive agents. This study was undertaken to determine the effect of a selective cyclooxygenase-2 (COX-2) inhibitor, celecoxib, on the antihypertensive effects of the angiotensin II type 1 receptor (AT1) antagonist, losartan potassium. We studied the effect of oral treatment with losartan (30 mg/kg), celecoxib (3 mg/kg), and their combination on the mean arterial blood pressure (MAP), plasma renin activity (PRA), and plasma prostaglandin E2 (PGE2) in male Sprague-Dawley rats with renovascular hypertension (RVH) induced by partial subdiaphragmatic aortic constriction. Treatment was continued for 7 days after aortic coarctation. Aortic coarctation led to significant increases in the MAP, PRA, and plasma PGE2. In RVH rats, losartan treatment caused a significant decrease of MAP with a significant increase in both plasma PGE2 and PRA. Celecoxib caused a nonsignificant change in MAP with a significant decrease in the raised levels of plasma PGE2 and PRA. Concomitant administration of celecoxib and losartan did not significantly affect the lowering effect of losartan on MAP with a subsequent significant decrease in the plasma PGE2 and PRA in RVH rats. Therefore, celecoxib could be used in renin-dependent hypertensive patients who receive losartan, without fear of a rise in their blood pressure.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AGTR1Humanrenovascular hypertension  ISOAgtr1a (Rattus norvegicus) RGD 
Agtr1aRatrenovascular hypertension  IMP  RGD 
Agtr1aMouserenovascular hypertension  ISOAgtr1a (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Agtr1a  (angiotensin II receptor, type 1a)

Genes (Mus musculus)
Agtr1a  (angiotensin II receptor, type 1a)

Genes (Homo sapiens)
AGTR1  (angiotensin II receptor type 1)


Additional Information