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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:secondary hypertension
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Accession:DOID:11130 term browser browse the term
Synonyms:primary_id: RDO:9001819
 xref: ICD10CM:I15;   ICD9CM:405;   NCI:C3657
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
Hypertensive Nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen treatment IEP RGD PMID:22089474 RGD:8548895 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a treatment IMP RGD PMID:22089474 RGD:8548895 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Cfl1 cofilin 1 IEP protein:increased phosphorylation:kidney (rat) RGD PMID:26450610 RGD:11520804 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Col1a1 collagen type I alpha 1 chain IEP mRNA:increased expression:juxtamedullary cortex (rat) RGD PMID:17977875 RGD:2290351 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Hp haptoglobin treatment IEP RGD PMID:24029866 RGD:11041817 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Nppb natriuretic peptide B IMP RGD PMID:26063669 RGD:12910116 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nppbem2Mcwi natriuretic peptide B; zinc finger nuclease induced mutant 2, Medical College of Wisconsin IMP RGD PMID:26063669 RGD:12910116
G Postn periostin disease_progression IEP mRNA,protein:increased expression:kidney: RGD PMID:22403621 RGD:10041032 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IDA Strain: SHRSP RGD PMID:20671072 RGD:5509943 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Rag1 recombination activating 1 ameliorates IMP RGD PMID:23364523 PMID:23364523 RGD:7207429, RGD:7207429 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rag1em1Mcwi recombination activating gene 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin ameliorates IMP RGD PMID:23364523 RGD:7207429
G Shc1 SHC adaptor protein 1 IMP
IEP		 protein:increased expression:kidney RGD PMID:27270176 PMID:27270176 RGD:12792230, RGD:12792230 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Shc1em5Mcwi SHC adaptor protein 1; ZFN induced mutant 5, Medical College of Wisconsin IMP RGD PMID:27270176 RGD:12792230
Hypertensive Nephrosclerosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme treatment
severity		 IMP
ISO		 protein:increased expression:nephron tubule, kidney interstitium (human) RGD PMID:10580398 PMID:21346373 RGD:12879397, RGD:40818408 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin I converting enzyme 2 severity ISO mRNA, protein:decreased expression, increased expression:nephron tubule, kidney interstitium (human) RGD PMID:21346373 RGD:40818408 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
nephrosclerosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle ISO CTD Direct Evidence: marker/mechanism CTD PMID:30818366 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adrb1 adrenoceptor beta 1 disease_progression ISO associated with hypertension;DNA:missense mutations, haplotype:cds:p.S49G(rs1801252),p.R389G (rs1801253)(human): RGD PMID:19745105 RGD:7241815 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:30818366 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Alpk1 alpha-kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27542954 NCBI chr 2:216,126,939...216,247,180
Ensembl chr 2:216,128,825...216,247,157 		JBrowse link
G Col1a1 collagen type I alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:30818366 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:30818366 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30818366 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30818366 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Fgf2 fibroblast growth factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30818366 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28318631 NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223 		JBrowse link
G Ltb4r leukotriene B4 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:30818366 NCBI chr15:29,263,126...29,265,716 JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO DNA:transition, transversion:cds:g.677C>T, g.1298A>C (human) RGD PMID:21613384 RGD:6893469 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Ptgds prostaglandin D2 synthase ISO associated with Hypertension;protein:increased expression:serum, urine RGD PMID:11882588 RGD:1642584 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G S100a4 S100 calcium-binding protein A4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30818366 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30818366 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
renal hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:8763405 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a IEP mRNA:decreased expression:kidney: RGD PMID:7591011 RGD:10047107 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A IEP protein:decreased expression:vascular associated smooth muscle cell RGD PMID:17439406 RGD:2289672 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Crp C-reactive protein IEP protein:increased expression:serum RGD PMID:22188107 RGD:6907405 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 ISO RGD PMID:20495177 RGD:7243143
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 IEP
ISO		 protein:increased expression:kidney RGD PMID:10779386 PMID:20495177 RGD:1625381, RGD:7243143 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:16316349 RGD:1582711 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 ISO DNA: snp: 5'utr: -110A>C RGD PMID:21475814 RGD:7242785 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Il6 interleukin 6 IEP protein:increased expression:serum RGD PMID:22188107 RGD:6907405 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mmp2 matrix metallopeptidase 2 IDA RGD PMID:12923405 RGD:1302333 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp7 matrix metallopeptidase 7 IEP protein:increased expression:kidney medulla RGD PMID:12923405 RGD:1302333 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mmp9 matrix metallopeptidase 9 IDA RGD PMID:12923405 RGD:1302333 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 ISO DNA:missense mutation RGD PMID:18194667 RGD:2300400 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694 		JBrowse link
G Myh9 myosin, heavy chain 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18794856 NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457 		JBrowse link
G Nos2 nitric oxide synthase 2 IMP RGD PMID:20360752 RGD:4891374 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 IDA RGD PMID:20938214 RGD:4891989 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppa natriuretic peptide A IEP
ISO		 protein:increased expression:plasma:
CTD Direct Evidence: marker/mechanism
associated with Hypertension;protein:increased expression:plasma		 CTD
RGD		 PMID:8763405 PMID:20139323 PMID:12697975 PMID:15241786 RGD:7248593, RGD:7248660, RGD:7248617 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B IEP
ISO		 protein:increased expression:serum
associated with Hypertension;protein:increased expression:plasma
protein:increased expression:plasma:		 RGD PMID:22188107 PMID:12697975 PMID:20139323 RGD:6907405, RGD:7248660, RGD:7248593 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 IEP protein:increased expression:kidney medulla RGD PMID:12923405 RGD:1302333 NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558 		JBrowse link
G Tnf tumor necrosis factor IEP protein:increased expression:serum RGD PMID:22188107 RGD:6907405 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Renoprival Hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase IMP RGD PMID:22733796 RGD:7206853 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
renovascular hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme treatment IEP
IDA		 RGD PMID:22342460 PMID:20630208 RGD:6893471, RGD:8157609 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Adm adrenomedullin ISO protein:increased expression:plasma RGD PMID:15284680 RGD:1625303 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Adrb1 adrenoceptor beta 1 IMP
IDA		 RGD PMID:17278011 PMID:15592645 RGD:7241568, RGD:7241580 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a IMP
IEP		 mRNA:decreased expression:kidney: RGD PMID:21326341 PMID:9644212 PMID:16796846 RGD:5129177, RGD:10047119, RGD:5147455 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b treatment IEP mRNA:increased expression:kidney: RGD PMID:9644212 RGD:10047119 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 IDA
IMP		 RGD PMID:21189405 PMID:18158356 RGD:6903867, RGD:6903868 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A IEP mRNA:altered expression:brain RGD PMID:15613739 RGD:2300323 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IDA RGD PMID:17062848 RGD:2311383 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 IDA RGD PMID:17062848 RGD:2311383 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969 		JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 IEP mRNA:increased expression:heart left ventricle RGD PMID:12708758 RGD:10755511 NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588 		JBrowse link
G Fn1 fibronectin 1 IDA RGD PMID:17324142 RGD:7205461 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase treatment IEP RGD PMID:22684021 RGD:10449172 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gja1 gap junction protein, alpha 1 IEP RGD PMID:11422751 RGD:7207851 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gja5 gap junction protein, alpha 5 IEP RGD PMID:11422751 RGD:7207851 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:urine: RGD PMID:22923545 RGD:7245500 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hdac8 histone deacetylase 8 treatment IEP RGD PMID:27673327 RGD:13208809 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923 		JBrowse link
G Lama2 laminin subunit alpha 2 IEP mRNA:decreased expression:heart RGD PMID:10773239 RGD:1600206 NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530 		JBrowse link
G Lcn2 lipocalin 2 ISO protein:increased expression:urine,plasma RGD PMID:22923545 RGD:7245500 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Mpo myeloperoxidase IEP protein:increased activity:heart, brain, kidney RGD PMID:19549002 RGD:7174698 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nos1 nitric oxide synthase 1 IEP RGD PMID:16788145 RGD:1642130 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO CTD Direct Evidence: therapeutic CTD PMID:18641695 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pdgfa platelet derived growth factor subunit A IEP mRNA:increased expression:vascular associated smooth muscle cell RGD PMID:17439406 RGD:2289672 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Prl prolactin IEP protein:increased expression:plasma RGD PMID:17316702 RGD:1642574 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ptger3 prostaglandin E receptor 3 IEP protein:increased expression:kidney (rat) RGD PMID:16788145 RGD:1642130 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 IMP RGD PMID:17766473 RGD:2300258 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEP protein:increased expression:nucleus, kidney RGD PMID:18032469 RGD:2298840 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin ISO mRNA:increased expression:renal cortex (mouse)
protein:increased activity:blood plasma (human)		 RGD PMID:22378822 PMID:2240003 RGD:6892688, RGD:125097504 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 treatment IEP RGD PMID:12218313 RGD:727424 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 treatment IEP RGD PMID:12218313 RGD:727424 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417 		JBrowse link
G Spp1 secreted phosphoprotein 1 IDA RGD PMID:12620700 RGD:1581326 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Trip11 thyroid hormone receptor interactor 11 ISO ClinVar Annotator: match by term: Goldblatt hypertension ClinVar PMID:20089971 PMID:25741868 PMID:29872333 PMID:30728324 NCBI chr 6:120,995,242...121,067,693
Ensembl chr 6:120,998,733...121,067,781 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17251
    disease of anatomical entity 16595
      cardiovascular system disease 4520
        vascular disease 3439
          hypertension 1509
            secondary hypertension 88
              benign secondary hypertension + 0
              malignant secondary hypertension + 0
              renal hypertension + 88
Path 2
Term Annotations click to browse term
  disease 17251
    disease of anatomical entity 16595
      cardiovascular system disease 4520
        vascular disease 3439
          artery disease 2401
            hypertension 1509
              secondary hypertension 88
                benign secondary hypertension + 0
                malignant secondary hypertension + 0
                renal hypertension + 88
paths to the root