Ptger3 (prostaglandin E receptor 3)

Gene: Ptger3 (prostaglandin E receptor 3) Chinchilla lanigera

Analyze

Symbol:

Ptger3

Name:

prostaglandin E receptor 3

RGD ID:

8755411

Description:

ENCODES a protein that exhibits prostaglandin E receptor activity (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); bicarbonate transport (ortholog); cellular response to forskolin (ortholog); ASSOCIATED WITH asthma (ortholog); Brain Injuries (ortholog); cicatricial pemphigoid (ortholog); FOUND IN brush border membrane (ortholog); cell surface (ortholog); neuronal cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

prostaglandin E receptor 3 (subtype EP3); prostaglandin E2 receptor EP3 subtype

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955423	21,096,926 - 21,164,435 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

asthma (ISO)

Brain Injuries (ISO)

cicatricial pemphigoid (ISO)

colon cancer (ISO)

Colonic Neoplasms (ISO)

drug allergy (ISO)

Edema (ISO)

Fetal Growth Retardation (ISO)

Fever (ISO)

genetic disease (ISO)

Hyperalgesia (ISO)

intellectual disability (ISO)

leiomyoma (ISO)

membranous glomerulonephritis (ISO)

Myocardial Reperfusion Injury (ISO)

NSAID-Enteropathy (ISO)

Oxygen-Induced Retinopathy (ISO)

polycystic ovary syndrome (ISO)

renovascular hypertension (ISO)

Stevens-Johnson syndrome (ISO)

thrombosis (ISO)

withdrawal disorder (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ISO)

bicarbonate transport (ISO)

cellular response to forskolin (ISO)

cellular response to interleukin-1 (ISO)

cellular response to lipopolysaccharide (ISO)

desensitization of G protein-coupled receptor signaling pathway (ISO)

female pregnancy (ISO)

fever generation (ISO)

intestine smooth muscle contraction (ISO)

maternal process involved in parturition (ISO)

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway (ISO)

negative regulation of calcium ion transmembrane transport (ISO)

negative regulation of circadian sleep/wake cycle, wakefulness (ISO)

negative regulation of forebrain neuron differentiation (ISO)

negative regulation of gastrin-induced gastric acid secretion (ISO)

negative regulation of insulin secretion (ISO)

negative regulation of norepinephrine secretion (ISO)

negative regulation of potassium ion transmembrane transport (ISO)

phospholipase C-activating G protein-coupled receptor signaling pathway (ISO)

positive regulation of cAMP-mediated signaling (ISO)

positive regulation of circadian sleep/wake cycle, non-REM sleep (ISO)

positive regulation of colon smooth muscle contraction (ISO)

positive regulation of cytosolic calcium ion concentration (ISO)

positive regulation of fever generation (ISO)

positive regulation of gastric mucosal blood circulation (ISO)

positive regulation of gene expression (ISO)

positive regulation of inhibitory G protein-coupled receptor phosphorylation (ISO)

positive regulation of myofibroblast contraction (ISO)

positive regulation of neutrophil extravasation (ISO)

positive regulation of protein phosphorylation (ISO)

positive regulation of smooth muscle contraction involved in micturition (ISO)

positive regulation of urine volume (ISO)

positive regulation of vasoconstriction (ISO)

prostaglandin receptor internalization (ISO)

receptor internalization (ISO)

regulation of circadian sleep/wake cycle, wakefulness (ISO)

regulation of norepinephrine secretion (ISO)

response to estradiol (ISO)

response to lipopolysaccharide (ISO)

response to progesterone (ISO)

response to salt (ISO)

response to xenobiotic stimulus (ISO)

urinary bladder smooth muscle contraction (ISO)

Cellular Component

brush border membrane (ISO)

cell surface (ISO)

neuronal cell body (ISO)

nuclear membrane (ISO)

plasma membrane (ISO)

proximal neuron projection (ISO)

Molecular Function

prostaglandin E receptor activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ptger3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955423	21,096,926 - 21,164,435 (+)	NCBI	ChiLan1.0	ChiLan1.0

PTGER3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	70,852,358 - 71,047,816 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	70,852,353 - 71,047,816 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	71,318,041 - 71,513,499 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	71,090,624 - 71,286,079 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	71,188,848 - 71,225,512	NCBI
Celera	1	69,607,257 - 69,802,711 (-)	NCBI		Celera
Cytogenetic Map	1	p31.1	NCBI
HuRef	1	69,428,653 - 69,623,748 (-)	NCBI		HuRef
CHM1_1	1	71,432,956 - 71,628,842 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	70,730,386 - 70,925,810 (-)	NCBI		T2T-CHM13v2.0

Ptger3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	157,272,459 - 157,350,392 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	157,272,529 - 157,351,525 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	157,566,821 - 157,644,758 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	157,566,892 - 157,645,888 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	157,229,856 - 157,307,722 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	157,502,185 - 157,580,051 (+)	NCBI		MGSCv36	mm8
Celera	3	164,034,893 - 164,113,113 (+)	NCBI		Celera
Cytogenetic Map	3	H4	NCBI
cM Map	3	81.32	NCBI

Ptger3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	249,264,985 - 249,409,966 (+)	NCBI		GRCr8
mRatBN7.2	2	246,606,131 - 246,750,970 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	246,606,183 - 246,684,434 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	254,318,634 - 254,403,084 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	252,212,449 - 252,296,915 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	247,184,945 - 247,269,307 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	263,895,093 - 263,979,682 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	263,895,241 - 263,979,698 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	282,614,936 - 282,760,641 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	255,680,691 - 255,759,202 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	255,695,297 - 255,773,809 (+)	NCBI
Celera	2	238,415,230 - 238,493,209 (+)	NCBI		Celera
Cytogenetic Map	2	q45	NCBI

PTGER3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	155,837,765 - 156,032,636 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	154,996,361 - 155,091,432 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	70,076,610 - 70,271,475 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	72,058,998 - 72,254,063 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	72,059,441 - 72,254,063 (-)	Ensembl	panpan1.1		panPan2

PTGER3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	74,932,789 - 74,986,573 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	77,575,622 - 77,753,496 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	75,490,852 - 75,668,770 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	75,490,852 - 75,714,812 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	75,042,922 - 75,220,964 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	74,940,272 - 75,118,118 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	75,437,418 - 75,616,001 (+)	NCBI		UU_Cfam_GSD_1.0

Ptger3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	83,239,312 - 83,315,450 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936591	1,174,069 - 1,249,410 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936591	1,174,364 - 1,250,233 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTGER3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	141,958,955 - 142,161,286 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	141,958,955 - 142,160,437 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	131,574,664 - 131,776,520 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PTGER3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	62,093,830 - 62,293,360 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	62,095,458 - 62,174,959 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	55,495,971 - 55,576,801 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ptger3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624742	25,177,340 - 25,356,911 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005385244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01023935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01208544	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005385244 ⟹ XP_005385301

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955423	21,096,926 - 21,164,435 (+)	NCBI

Sequence:

show sequence

GCGGGCACCGCGGCGCCCGGAGCGGCGCCGTCTCGAGGGCACCGATCCCCGGCCGCGCGCCCCG
CACCATGGAGCGCAGCCCGGGCCCGGGCTGGGTCTGGGTCGCCGCCGCCCTGGGCCACCGCCCG
CGCCCTGCGTGCCAGCTCTCCCTGCCGCTGCGCTCCGGGCCCCGACGCGTCCTCGCCTCGAAGC
CGACATGAAGACGAGCCGGGGCGACGGCGGGGGCGCCCCCTTCTGCACCCGCCTCAACCACTCG
GACCCGGGCATGTGGGCGCCCGAGCGCTCCGCCGAGGCGCGGAGCAACCTGAGCCGCGCGCCGG
GGCCGGGCGAGGACTGCGGGTCGGTGTCGGTGGCCTTCCCCATCACCATGATGCTCACGGGCTT
CGTGGGCAACGCGCTGGCCATGCTGCTCGTGTCGCGGAGCTACCGGCGCCGGGAGAGCAAGCGC
AAGAAGTCCTTCCTGCTGTGCATCGGCTGGCTGGCGCTCACCGACCTGGTCGGGCAGCTGCTCA
CCAGCCCGGTGGTCATCGTCGTGTACCTGTCGCAGCAGCGCTGGGAGCAGCACGACCCGTCGGG
CCGGCTGTGCACCTTCTTCGGCCTCACCATGACGGTCTTCGGGCTGTCCTCGCTGCTCATCGCC
AGCGCCATGGCCGTCGAGCGCGCGCTGGCCATCCGCGCGCCGCACTGGTACGCGAGCCACATGA
AGACGCGCGCCACGCGCGCCGTGCTGCTCGGCGTGTGGCTGGCCGTGCTCGCCTTCGCCCTGCT
GCCGGTGCTGGGCGTGGGCCAGTACACGGTGCAGTGGCCCGGGACCTGGTGCTTCATCAGCACC
GCGCGGGGGGGCAACGGGACCAGCTCCGCGCACAACTGGGGCAACCTCTTCTTCGCCTCCACCT
TCGCCTTCCTGGGGCTCCTGGCGCTGGCCGTGACCTTCGCCTGCAACCTGGCCACCATCAAGGC
CCTGGTGTCCCGCTGCCGGGCCAAGGCTGCGGCGGCGCAGTCCAGCGCCCAGTGGGGCCGCATC
ACCACCGAGACGGCCCTGCAGCTCATGGGCATCATGTGCGTGCTGTCGGTGTGCTGGTCGCCGC
TCTTGATAATGATGTTGAGAATGATCTTCAATCAGACATCAGTTGAGCACTGCAAGACGCAGAC
GGAAAAGCAGAAAGAATGCCATTTCTTCTTGATAGCTGTGCGTTTGGCTTCCCTGAACCAGATC
TTGGATCCCTGGGTTTATCTGCTGCTAAGAAAGATCCTTCTTCGAAAGTTTTGCCAGATCAGGT
TCCACACAAACAACTATGCATCCAGCTCCACGTCCCTGCCCCACCAGTGTTCCTCAACCTTGAT
GTGGAGCGACCGCCTGGAAAGATAATGCAAGAATGGAGCTGGACTTTTTGCACAACCCCTGCCT
CCCTGAGTTGTGTATTTCTTCCCACATCAGAAGGAGAATTTTATGTTTTCATTTGGAGCATATC
TTTATTTTTGTCTCATTTTTTTTTTTTAATTTT

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Protein Sequences


Protein RefSeqs	XP_005385301	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000007263.1

RefSeq Acc Id:

XP_005385301 ⟸ XM_005385244

- UniProtKB:

A0A8C2UYJ2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKTSRGDGGGAPFCTRLNHSDPGMWAPERSAEARSNLSRAPGPGEDCGSVSVAFPITMMLTGFV
GNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVIVVYLSQQRWEQHDPSGR
LCTFFGLTMTVFGLSSLLIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLP
VLGVGQYTVQWPGTWCFISTARGGNGTSSAHNWGNLFFASTFAFLGLLALAVTFACNLATIKAL
VSRCRAKAAAAQSSAQWGRITTETALQLMGIMCVLSVCWSPLLIMMLRMIFNQTSVEHCKTQTE
KQKECHFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRFHTNNYASSSTSLPHQCSSTLMW
SDRLER

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Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000005105	UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000007377.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	EP3_rcpt_2	UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	Prostanoid_rcpt	UniProtKB/TrEMBL
	Prostglndn_DP_rcpt	UniProtKB/TrEMBL
	Prostglndn_EP3_rcpt	UniProtKB/TrEMBL
NCBI Gene	Ptger3	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER	UniProtKB/TrEMBL
	PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	PROSTAGLNDNR	UniProtKB/TrEMBL
	PROSTANOIDR	UniProtKB/TrEMBL
	PRSTNOIDE32R	UniProtKB/TrEMBL
	PRSTNOIDEP3R	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A8C2UYJ2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Ptger3	prostaglandin E receptor 3		prostaglandin E receptor 3 (subtype EP3)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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