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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:membranoproliferative glomerulonephritis
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Accession:DOID:2920 term browser browse the term
Definition:Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.
Synonyms:exact_synonym: Dense Deposit Disease;   Hypocomplementemic Glomerulonephritides;   Hypocomplementemic Glomerulonephritis;   Lobular glomerulonephritis;   MPGN;   Membranoproliferative Glomerulonephritides;   Membranoproliferative Glomerulonephritis, Type I;   Mesangiocapillary Glomerulonephritides;   Mesangiocapillary Glomerulonephritis;   Mesangiocapillary Glomerulonephritis, Type I;   Subendothelial Membranoproliferative Glomerulonephritis;   chronic glomerulonephritis, lobular
 narrow_synonym: MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS WITH COMPLEMENT FACTOR H DEFICIENCY;   MESANGIOCAPILLARY GLOMERULONEPHRITIS, TYPE II;   Membranoproliferative Glomerulonephritis Type II;   Membranoproliferative Glomerulonephritis, Type III;   NON-IMMUNOGLOBULIN-MEDIATED MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS
 primary_id: MESH:D015432
 xref: GARD:11982;   MIM:PS137950;   NCI:C34644
For additional species annotation, visit the Alliance of Genome Resources.


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membranoproliferative glomerulonephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1556257 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696 		JBrowse link
G ANGPT2 angiopoietin 2 ISO protein:increased expression:glomerulus (rat) RGD PMID:16014048 PMID:18272601 RGD:2314193 RGD:2314222 NCBI chr15:37,544,177...37,600,925
Ensembl chr15:37,544,707...37,599,041 		JBrowse link
G C1QA complement C1q A chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:8840296 NCBI chr 6:80,586,259...80,589,213
Ensembl chr 6:80,586,280...80,589,204 		JBrowse link
G C3 complement C3 ISO ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis ClinVar PMID:32581362 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 treatment ISO RGD PMID:10411686 RGD:8549648 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G CCN2 cellular communication network factor 2 ISO protein:increased expression:kidney, glomerulus (rat) RGD PMID:15172885 RGD:1601118 NCBI chr 1:31,674,398...31,677,697
Ensembl chr 1:31,674,394...31,677,691 		JBrowse link
G CCR6 C-C motif chemokine receptor 6 treatment ISO RGD PMID:23192593 RGD:7483632 NCBI chr 1:2,016,600...2,034,172
Ensembl chr 1:2,018,608...2,019,821 		JBrowse link
G CDK2 cyclin dependent kinase 2 ISO RGD PMID:17893107 RGD:2293563 NCBI chr 5:21,365,723...21,372,170
Ensembl chr 5:21,365,764...21,372,168 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO protein:decreased expression:kidney RGD PMID:16787597 RGD:2293620 NCBI chr 5:59,731,224...59,735,831
Ensembl chr 5:59,731,206...59,735,831 		JBrowse link
G CFB complement factor B ISO RGD PMID:2329415 PMID:12091909 RGD:7242760 RGD:734771 NCBI chr 7:24,034,077...24,040,523
Ensembl chr 7:24,034,332...24,041,179 		JBrowse link
G CFH complement factor H ISO ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis | ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis, type II | ClinVar Annotator: match by term: Non-immunoglobulin-mediated membranoproliferative glomerulonephritis ClinVar PMID:21415311 PMID:22223606 PMID:22403278 PMID:25741868 PMID:28492532 More...
G CFI complement factor I ISO RGD PMID:18202746 RGD:6906892 NCBI chr 8:112,430,824...112,470,844
Ensembl chr 8:112,433,633...112,470,832 		JBrowse link
G EDN1 endothelin 1 treatment ISO mRNA, protein:increased expression:glomerulus (rat) RGD PMID:8569091 PMID:11601021 RGD:4144848 RGD:8662296 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G EP300 E1A binding protein p300 treatment ISO RGD PMID:24344329 RGD:9588308 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760 		JBrowse link
G F5 coagulation factor V ISO RGD PMID:15172885 RGD:1601118 NCBI chr 4:81,403,273...81,484,908
Ensembl chr 4:81,403,274...81,485,066 		JBrowse link
G FN1 fibronectin 1 ISO RGD PMID:10082755 RGD:7206847 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,043 		JBrowse link
G KCNT2 potassium sodium-activated channel subfamily T member 2 ISO ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis ClinVar PMID:32581362
G LOC110258578 interleukin-1 beta-like ISO RGD PMID:21871881 RGD:7175308
G MYOC myocilin ISO protein:increased expression:renal glomerulus (rat) RGD PMID:15610237 RGD:7401266 NCBI chr 9:114,087,370...114,098,765
Ensembl chr 9:114,087,378...114,098,745 		JBrowse link
G PFN1 profilin 1 ISO RGD PMID:8651905 RGD:729497 NCBI chr12:51,962,642...51,965,570
Ensembl chr12:51,961,952...51,965,464 		JBrowse link
G PON1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16175651 NCBI chr 9:74,943,646...74,974,720
Ensembl chr 9:74,926,048...74,974,723 		JBrowse link
G PRF1 perforin 1 ISO mRNA:increased expression:glomerulus RGD PMID:10886554 RGD:1599935 NCBI chr14:73,515,306...73,520,256
Ensembl chr14:73,512,769...73,520,202 		JBrowse link
G SPARC secreted protein acidic and cysteine rich ISO mRNA:increased expression:glomerulus RGD PMID:8644857 RGD:2300070 NCBI chr16:71,368,164...71,380,972
Ensembl chr16:71,357,586...71,381,161 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 ISO RGD PMID:11703592 RGD:1601601 NCBI chr13:16,784,370...16,875,828
Ensembl chr13:16,784,490...16,878,160 		JBrowse link
G TLR1 toll like receptor 1 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr 8:30,147,600...30,155,454
Ensembl chr 8:30,147,624...30,155,466 		JBrowse link
G TLR2 toll like receptor 2 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
G TLR4 toll like receptor 4 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TLR5 toll like receptor 5 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr10:19,387,666...19,410,024
Ensembl chr10:19,387,666...19,410,024 		JBrowse link
G TLR6 toll like receptor 6 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr 8:30,159,744...30,180,650
Ensembl chr 8:30,159,754...30,180,650 		JBrowse link
G TLR7 toll like receptor 7 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr  X:9,573,178...9,576,987 JBrowse link
G TLR8 toll like receptor 8 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr  X:9,551,284...9,616,762
Ensembl chr  X:9,597,604...9,616,757 		JBrowse link
G TLR9 toll like receptor 9 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr13:34,353,444...34,370,990
Ensembl chr13:34,349,609...34,357,673 		JBrowse link
G TSLP thymic stromal lymphopoietin ISO CTD Direct Evidence: marker/mechanism
OMIM:305800		 CTD
MouseDO		 PMID:17686814 NCBI chr 2:115,832,152...115,837,572 JBrowse link
C3 Glomerulopathy 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFH complement factor H ISO ClinVar Annotator: match by term: C3 GLOMERULOPATHY 3 | ClinVar Annotator: match by term: CFH-Related Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II ClinVar PMID:8072530 PMID:9536098 PMID:11158219 PMID:11978762 PMID:12424708 More...
Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFH complement factor H ISO DNA:SNPs,Haplotype:: RGD PMID:17517971 RGD:7364995
Glomerulopathy with Giant Fibrillar Deposits term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO ClinVar Annotator: match by term: Glomerulopathy with fibronectin deposits 2 ClinVar PMID:25741868 PMID:28492532 PMID:29100092 PMID:32200603 NCBI chr15:117,617,584...117,649,063
Ensembl chr15:117,617,502...117,649,107 		JBrowse link
G FN1 fibronectin 1 ISO ClinVar Annotator: match by term: Glomerulopathy with fibronectin deposits 2 OMIM
ClinVar		 PMID:1544672 PMID:7564073 PMID:7747733 PMID:9536098 PMID:12042895 More... NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,043 		JBrowse link
G INF2 inverted formin 2 ISO ClinVar Annotator: match by term: Glomerulopathy with fibronectin deposits 2 ClinVar PMID:25741868
hypotrichosis-lymphedema-telangiectasia-renal defect syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOX18 SRY-box transcription factor 18 ISO ClinVar Annotator: match by term: Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome OMIM
ClinVar		 PMID:2484451 PMID:12740761 PMID:24697860 PMID:25741868 PMID:28492532 More... NCBI chr17:62,869,868...62,871,758
Ensembl chr17:62,869,870...62,871,748 		JBrowse link
nephrotic syndrome type 7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DGKE diacylglycerol kinase epsilon susceptibility ISO ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 7 | ClinVar Annotator: match by term: DGKE-related condition | ClinVar Annotator: match by term: Hemolytic uremic syndrome with DGKE deficiency | ClinVar Annotator: match by term: Immunoglobulin-mediated membranoproliferative glomerulonephritis | ClinVar Annotator: match by term: Nephrotic syndrome, type 7 ClinVar
OMIM		 PMID:23274426 PMID:23542698 PMID:24747643 PMID:25135762 PMID:25349199 More... NCBI chr12:33,141,439...33,172,412
Ensembl chr12:33,141,505...33,172,405 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15394
    disease of anatomical entity 15088
      immune system disease 4558
        membranoproliferative glomerulonephritis 37
          C3 Glomerulopathy 3 1
          Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency 1
          Glomerulonephritis with Isolated C3 Deposits and Factor I Deficiency 0
          Glomerulopathy with Giant Fibrillar Deposits 3
          Membranoproliferative Glomerulonephritis, X-Linked 0
          hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 1
          nephrotic syndrome type 7 1
Path 2
Term Annotations click to browse term
  disease 15394
    disease of anatomical entity 15088
      Urogenital Diseases 4839
        urinary system disease 2385
          kidney disease 2145
            nephritis 397
              glomerulonephritis 347
                mesangial proliferative glomerulonephritis 46
                  Chronic Mesangial Proliferative Glomerulonephritis 39
                    membranoproliferative glomerulonephritis 37
                      C3 Glomerulopathy 3 1
                      Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency 1
                      Glomerulonephritis with Isolated C3 Deposits and Factor I Deficiency 0
                      Glomerulopathy with Giant Fibrillar Deposits 3
                      Membranoproliferative Glomerulonephritis, X-Linked 0
                      hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 1
                      nephrotic syndrome type 7 1
paths to the root