CFB (complement factor B) - Rat Genome Database

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Gene: CFB (complement factor B) Sus scrofa
Analyze
Symbol: CFB
Name: complement factor B
RGD ID: 14138275
Description: ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN complement activation (ortholog); complement activation, alternative pathway (ortholog); response to lipopolysaccharide (ortholog); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); age related macular degeneration 14 (ortholog); anterior uveitis (ortholog); FOUND IN extracellular space (ortholog); plasma membrane (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B-factor, properdin; BF; C3/C5 convertase; properdin; Properdin factor B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,033,740 - 24,041,179 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,034,077 - 24,040,523 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,771,678 - 27,777,773 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
age related macular degeneration 14  (ISO)
age related macular degeneration 7  (ISO)
anterior uveitis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
atypical hemolytic-uremic syndrome  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Behcet's disease  (ISO)
beta thalassemia  (ISO)
boutonneuse fever  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
bullous pemphigoid  (ISO)
Choroidal Neovascularization  (ISO)
complement component 2 deficiency  (ISO)
Complement Factor B Deficiency  (ISO)
conjunctivitis  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
erythema nodosum  (ISO)
Experimental Autoimmune Myasthenia Gravis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
factor VIII deficiency  (ISO)
focal segmental glomerulosclerosis  (ISO)
IgA glomerulonephritis  (ISO)
Kidney Reperfusion Injury  (ISO)
lepromatous leprosy  (ISO)
lupus nephritis  (ISO)
macular degeneration  (ISO)
membranoproliferative glomerulonephritis  (ISO)
membranous glomerulonephritis  (ISO)
Meningococcal Infections  (ISO)
Multifocal Choroiditis  (ISO)
myasthenia gravis  (ISO)
neutropenia  (ISO)
otitis media  (ISO)
paracoccidioidomycosis  (ISO)
polycystic kidney disease  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
psoriasis  (ISO)
pyelonephritis  (ISO)
Refractory Anemia with Excess of Blasts  (ISO)
retinal degeneration  (ISO)
Sepsis  (ISO)
sickle cell anemia  (ISO)
sinusitis  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
type 1 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
CFB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,033,740 - 24,041,179 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,034,077 - 24,040,523 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,771,678 - 27,777,773 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CFB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,946,095 - 31,952,084 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl631,945,650 - 31,952,086 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,913,872 - 31,919,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,021,752 - 32,027,839 (+)NCBINCBI36Build 36hg18NCBI36
Build 34632,021,760 - 32,027,839NCBI
Celera633,513,483 - 33,519,623 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,700,690 - 31,706,830 (+)NCBIHuRef
CHM1_1631,915,802 - 31,921,942 (+)NCBICHM1_1
T2T-CHM13v2.0631,799,300 - 31,805,289 (+)NCBIT2T-CHM13v2.0
Cfb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,075,350 - 35,081,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,075,350 - 35,081,494 (-)EnsemblGRCm39 Ensembl
GRCm381734,856,374 - 34,862,514 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,856,374 - 34,862,518 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,993,319 - 34,999,459 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,464,437 - 34,470,273 (-)NCBIMGSCv36mm8
Celera1737,951,682 - 37,957,822 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.41NCBI
Cfb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2203,970,643 - 3,976,510 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,951,474 - 3,976,505 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,670,648 - 4,676,510 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0204,032,396 - 4,038,258 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0204,569,562 - 4,575,424 (+)NCBIRnor_WKY
Rnor_6.0204,536,206 - 4,542,073 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,536,212 - 4,542,073 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,536,203 - 4,561,066 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,616,005 - 6,621,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera204,054,184 - 4,060,051 (-)NCBICelera
Cytogenetic Map20p12NCBI
Cfb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437461,235 - 470,464 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955437461,235 - 466,908 (+)NCBIChiLan1.0ChiLan1.0
CFB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1632,492,982 - 32,499,396 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0631,606,716 - 31,612,782 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CFB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,400,143 - 1,406,267 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,535,347 - 1,541,465 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,542,448 - 1,548,565 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,542,461 - 1,549,232 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,399,726 - 1,405,840 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,468,093 - 1,474,210 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,533,422 - 1,539,539 (+)NCBIUU_Cfam_GSD_1.0
Cfb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,959,298 - 35,965,192 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367271,595,872 - 1,602,274 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604431,862,788 - 31,868,803 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,310,247 - 24,317,366 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,310,344 - 24,316,482 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8
Low 2 2 3 5 1 23 2 3 3
Below cutoff 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000036375   ⟹   ENSSSCP00000029905
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl724,033,740 - 24,041,179 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000039670   ⟹   ENSSSCP00000040984
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl724,034,332 - 24,041,179 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000075286   ⟹   ENSSSCP00000074131
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl724,033,740 - 24,040,469 (+)Ensembl
RefSeq Acc Id: NM_001101824   ⟹   NP_001095294
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1724,034,429 - 24,040,523 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021097856   ⟹   XP_020953515
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1724,034,077 - 24,040,523 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020953515   ⟸   XM_021097856
- Peptide Label: isoform X1
- UniProtKB: A0A287AAZ9 (UniProtKB/TrEMBL),   A0A8D1JCF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001095294   ⟸   NM_001101824
- Peptide Label: precursor
- UniProtKB: A5PF00 (UniProtKB/TrEMBL),   A0A8D0Q4G6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000029905   ⟸   ENSSSCT00000036375
RefSeq Acc Id: ENSSSCP00000040984   ⟸   ENSSSCT00000039670
RefSeq Acc Id: ENSSSCP00000074131   ⟸   ENSSSCT00000075286
Protein Domains
Peptidase S1   Sushi   VWFA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000024914 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015076454 UniProtKB/TrEMBL
  ENSSSCG00025067695 UniProtKB/TrEMBL
  ENSSSCG00045039150 UniProtKB/TrEMBL
  ENSSSCG00050016661 UniProtKB/TrEMBL
  ENSSSCG00065021736 UniProtKB/TrEMBL
  ENSSSCG00070023194 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000001522.3 UniProtKB/TrEMBL
  ENSSSCP00000029905 ENTREZGENE
  ENSSSCP00000029905.3 UniProtKB/TrEMBL
  ENSSSCP00000040984 ENTREZGENE
  ENSSSCP00000040984.2 UniProtKB/TrEMBL
  ENSSSCP00000074131.1 UniProtKB/TrEMBL
  ENSSSCP00015043481.1 UniProtKB/TrEMBL
  ENSSSCP00015043541.1 UniProtKB/TrEMBL
  ENSSSCP00025041176.1 UniProtKB/TrEMBL
  ENSSSCP00025041380.1 UniProtKB/TrEMBL
  ENSSSCP00025041542.1 UniProtKB/TrEMBL
  ENSSSCP00025041703.1 UniProtKB/TrEMBL
  ENSSSCP00045048493.1 UniProtKB/TrEMBL
  ENSSSCP00050009636.1 UniProtKB/TrEMBL
  ENSSSCP00065011819.1 UniProtKB/TrEMBL
  ENSSSCP00065011824.1 UniProtKB/TrEMBL
  ENSSSCP00065011831.1 UniProtKB/TrEMBL
  ENSSSCP00070039012.1 UniProtKB/TrEMBL
  ENSSSCP00070039021.1 UniProtKB/TrEMBL
  ENSSSCP00070039026.1 UniProtKB/TrEMBL
  ENSSSCP00070039035.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000001564.5 UniProtKB/TrEMBL
  ENSSSCT00000036375 ENTREZGENE
  ENSSSCT00000036375.3 UniProtKB/TrEMBL
  ENSSSCT00000039670 ENTREZGENE
  ENSSSCT00000039670.2 UniProtKB/TrEMBL
  ENSSSCT00000075286.1 UniProtKB/TrEMBL
  ENSSSCT00015104089.1 UniProtKB/TrEMBL
  ENSSSCT00015104196.1 UniProtKB/TrEMBL
  ENSSSCT00025093845.1 UniProtKB/TrEMBL
  ENSSSCT00025094248.1 UniProtKB/TrEMBL
  ENSSSCT00025094605.1 UniProtKB/TrEMBL
  ENSSSCT00025094999.1 UniProtKB/TrEMBL
  ENSSSCT00045068188.1 UniProtKB/TrEMBL
  ENSSSCT00050022756.1 UniProtKB/TrEMBL
  ENSSSCT00065028919.1 UniProtKB/TrEMBL
  ENSSSCT00065028941.1 UniProtKB/TrEMBL
  ENSSSCT00065028957.1 UniProtKB/TrEMBL
  ENSSSCT00070046244.1 UniProtKB/TrEMBL
  ENSSSCT00070046253.1 UniProtKB/TrEMBL
  ENSSSCT00070046260.1 UniProtKB/TrEMBL
  ENSSSCT00070046268.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/TrEMBL
InterPro Compl_C2_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100124383 UniProtKB/TrEMBL
NCBI Gene CFB ENTREZGENE
PANTHER PTHR46393 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46393:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PIRSF Compl_C2_B UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287AAZ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VBJ0_PIG UniProtKB/TrEMBL
  A0A4X1VBR5_PIG UniProtKB/TrEMBL
  A0A4X1VE57_PIG UniProtKB/TrEMBL
  A0A5G2RCK2_PIG UniProtKB/TrEMBL
  A0A8D0Q4G6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Q508_PIG UniProtKB/TrEMBL
  A0A8D0T3W6_PIG UniProtKB/TrEMBL
  A0A8D0T4S5_PIG UniProtKB/TrEMBL
  A0A8D1JCF6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1XV77_PIG UniProtKB/TrEMBL
  A0A8D1XV90_PIG UniProtKB/TrEMBL
  A5PF00 ENTREZGENE, UniProtKB/TrEMBL
  B9TSR8_PIG UniProtKB/TrEMBL
  CFAB_PIG UniProtKB/Swiss-Prot
  F1RQW6_PIG UniProtKB/TrEMBL
  K7GPT9_PIG UniProtKB/TrEMBL
  Q03710 ENTREZGENE