Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methoctramine(4+)
go back to main search page
Accession:CHEBI:73453 term browser browse the term
Definition:An organic cation obtained by protonation of the four amino groups of methoctramine.
Synonyms:exact_synonym: N,N'-bis{6-[(2-methoxybenzyl)azaniumyl]hexyl}octane-1,8-diaminium
 related_synonym: Formula=C36H66N4O2;   InChI=1S/C36H62N4O2/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3/p+4;   InChIKey=RPMBYDYUVKEZJA-UHFFFAOYSA-R;   SMILES=COc1ccccc1C[NH2+]CCCCCC[NH2+]CCCCCCCC[NH2+]CCCCCC[NH2+]Cc1ccccc1OC;   methoctramine tetracation;   methoctraminium(4+)
 cyclic_relationship: is_conjugate_acid_of CHEBI:73339



show annotations for term's descendants           Sort by:
methoctramine tetrahydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein] CTD PMID:11306684 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:9846649 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions ISO methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM4 protein] CTD PMID:11306684 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] CTD PMID:9846649 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP methoctramine analog results in increased phosphorylation of MAPK1 protein CTD PMID:19576191 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP methoctramine analog results in increased phosphorylation of MAPK3 protein CTD PMID:19576191 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein] CTD PMID:17395621 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein] CTD PMID:17395621 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] CTD PMID:17395621 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases activity ISO methoctramine analog results in decreased activity of ODC1 protein; methoctramine results in decreased activity of ODC1 protein CTD PMID:19576191 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein] CTD PMID:17395621 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases activity ISO methoctramine analog results in increased activity of SAT1 protein; methoctramine results in increased activity of SAT1 protein CTD PMID:19576191 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link
G Tp53 tumor protein p53 increases expression EXP methoctramine analog results in increased expression of TP53 protein CTD PMID:19576191 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    chemical entity 19916
      molecular entity 19916
        ion 16729
          organic ion 9870
            organic cation 8917
              methoctramine(4+) 13
                methoctramine tetrahydrochloride 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    main group molecular entity 19866
                      s-block molecular entity 19698
                        hydrogen molecular entity 19684
                          hydrides 19159
                            inorganic hydride 18151
                              pnictogen hydride 18140
                                nitrogen hydride 18046
                                  ammonium 8317
                                    ammonium ion derivative 8312
                                      methoctramine(4+) 13
                                        methoctramine tetrahydrochloride 13
paths to the root