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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methoctramine tetrahydrochloride
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Accession:CHEBI:73452 term browser browse the term
Definition:A hydrochloride obtained by combining methoctramine with four molar equivalents of hydrochloric acid.
Synonyms:exact_synonym: N,N'-bis{6-[(2-methoxybenzyl)amino]hexyl}octane-1,8-diamine tetrahydrochloride;   N,N'-bis{6-[(2-methoxybenzyl)azaniumyl]hexyl}octane-1,8-diaminium tetrachloride
 related_synonym: Formula=C36H66Cl4N4O2;   InChI=1S/C36H62N4O2.4ClH/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2;;;;/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3;4*1H;   InChIKey=CDKGGOUDHGSFAF-UHFFFAOYSA-N;   Methoctramine;   SMILES=Cl.Cl.Cl.Cl.COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC;   methoctramine hydrochloride
 xref: CAS:104807-46-7
 xref_mesh: MESH:C054938
 xref: PMID:23597562;   Reaxys:5471061


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methoctramine tetrahydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein] CTD PMID:11306684 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:9846649 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions ISO methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM4 protein] CTD PMID:11306684 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] CTD PMID:9846649 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP methoctramine analog results in increased phosphorylation of MAPK1 protein CTD PMID:19576191 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP methoctramine analog results in increased phosphorylation of MAPK3 protein CTD PMID:19576191 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein] CTD PMID:17395621 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein] CTD PMID:17395621 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] CTD PMID:17395621 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases activity ISO methoctramine analog results in decreased activity of ODC1 protein; methoctramine results in decreased activity of ODC1 protein CTD PMID:19576191 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein] CTD PMID:17395621 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases activity ISO methoctramine analog results in increased activity of SAT1 protein; methoctramine results in increased activity of SAT1 protein CTD PMID:19576191 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Tp53 tumor protein p53 increases expression EXP methoctramine analog results in increased expression of TP53 protein CTD PMID:19576191 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    chemical entity 19773
      molecular entity 19772
        ion 15946
          organic ion 8466
            organic cation 7321
              methoctramine(4+) 13
                methoctramine tetrahydrochloride 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      halogen 18102
                        chlorine atom 17924
                          chlorine molecular entity 17924
                            elemental chlorine 8458
                              monoatomic chlorine 8442
                                chloride 8442
                                  chloride salt 8442
                                    organic chloride salt 898
                                      hydrochloride 682
                                        methoctramine tetrahydrochloride 13
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