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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methoctramine tetrahydrochloride
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Accession:CHEBI:73452 term browser browse the term
Definition:A hydrochloride obtained by combining methoctramine with four molar equivalents of hydrochloric acid.
Synonyms:exact_synonym: N,N'-bis{6-[(2-methoxybenzyl)amino]hexyl}octane-1,8-diamine tetrahydrochloride;   N,N'-bis{6-[(2-methoxybenzyl)azaniumyl]hexyl}octane-1,8-diaminium tetrachloride
 related_synonym: Formula=C36H66Cl4N4O2;   InChI=1S/C36H62N4O2.4ClH/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2;;;;/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3;4*1H;   InChIKey=CDKGGOUDHGSFAF-UHFFFAOYSA-N;   Methoctramine;   SMILES=Cl.Cl.Cl.Cl.COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC;   methoctramine hydrochloride
 xref: CAS:104807-46-7
 xref_mesh: MESH:C054938
 xref: PMID:23597562;   Reaxys:5471061



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methoctramine tetrahydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein] CTD PMID:11306684 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:9846649 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions ISO methoctramine inhibits the reaction [Scopolamine Derivatives binds to CHRM4 protein] CTD PMID:11306684 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO methoctramine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] CTD PMID:9846649 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP methoctramine analog results in increased phosphorylation of MAPK1 protein CTD PMID:19576191 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP methoctramine analog results in increased phosphorylation of MAPK3 protein CTD PMID:19576191 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of NFKB1 protein] CTD PMID:17395621 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS1 protein] CTD PMID:17395621 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] CTD PMID:17395621 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases activity ISO methoctramine analog results in decreased activity of ODC1 protein; methoctramine results in decreased activity of ODC1 protein CTD PMID:19576191 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP methoctramine inhibits the reaction [Mevinphos affects the localization of and affects the activity of RELA protein] CTD PMID:17395621 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases activity ISO methoctramine analog results in increased activity of SAT1 protein; methoctramine results in increased activity of SAT1 protein CTD PMID:19576191 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link
G Tp53 tumor protein p53 increases expression EXP methoctramine analog results in increased expression of TP53 protein CTD PMID:19576191 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      molecular entity 20054
        ion 16470
          organic ion 9184
            organic cation 8114
              methoctramine(4+) 13
                methoctramine tetrahydrochloride 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      halogen 18511
                        chlorine atom 18305
                          chlorine molecular entity 18305
                            elemental chlorine 8462
                              monoatomic chlorine 8445
                                chloride 8445
                                  chloride salt 8445
                                    organic chloride salt 927
                                      hydrochloride 697
                                        methoctramine tetrahydrochloride 13
paths to the root