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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:kuwanone G
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Accession:CHEBI:6146 term browser browse the term
Definition:A tetrahydroxyflavone isolated from the root barks of Morus alba and has been shown to exhibit anti-inflammatory activity.
Synonyms:exact_synonym: 8-[(1R,2S,3S)-2-(2,4-dihydroxybenzoyl)-2',4'-dihydroxy-5-methyl[1,2,3,6-tetrahydro[1,1'-biphenyl]]-3-yl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3-methylbut-2-en-1-yl)-4H-1-benzopyran-4-one
 related_synonym: Formula=C40H36O11;   InChI=1S/C40H36O11/c1-18(2)4-8-26-38(50)36-33(48)17-32(47)35(40(36)51-39(26)25-11-7-22(43)16-31(25)46)28-13-19(3)12-27(23-9-5-20(41)14-29(23)44)34(28)37(49)24-10-6-21(42)15-30(24)45/h4-7,9-11,13-17,27-28,34,41-48H,8,12H2,1-3H3/t27-,28-,34-/m0/s1;   InChIKey=APPXYONGBIXGRO-AIQWNVMPSA-N;   SMILES=CC(C)=CCc1c(oc2c([C@H]3C=C(C)C[C@H]([C@@H]3C(=O)c3ccc(O)cc3O)c3ccc(O)cc3O)c(O)cc(O)c2c1=O)-c1ccc(O)cc1O
 xref: CAS:75629-19-5;   KEGG:C10099;   KNApSAcK:C00001063
 xref_mesh: MESH:C095194
 xref: PMID:23806866


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kuwanone G term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO geranylgeranyl pyrophosphate inhibits the reaction [kuwanon G results in increased expression of ABCB1 protein]
kuwanon G results in increased expression of ABCB1 mRNA; kuwanon G results in increased expression of ABCB1 protein
CTD PMID:29355567 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression
multiple interactions
ISO kuwanon G results in increased expression of ABCG1 mRNA; kuwanon G results in increased expression of ABCG1 protein
geranylgeranyl pyrophosphate inhibits the reaction [kuwanon G results in increased expression of ABCG1 protein]
CTD PMID:29355567 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IFNG protein]; kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IL1B protein]; kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IL6 protein]; kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of TNF protein]; kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased uptake of Lipids] CTD PMID:29355567 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Grp gastrin releasing peptide multiple interactions ISO kuwanon G inhibits the reaction [GRP protein binds to GRPR protein] CTD PMID:7646517 NCBI chr18:61,563,458...61,576,818
Ensembl chr18:61,563,053...61,576,818
JBrowse link
G Grpr gastrin releasing peptide receptor multiple interactions ISO kuwanon G binds to and results in decreased activity of GRPR protein; kuwanon G inhibits the reaction [GRP protein binds to GRPR protein] CTD PMID:7646517 NCBI chr  X:32,746,259...32,786,266
Ensembl chr  X:32,745,873...32,786,359
JBrowse link
G Ifng interferon gamma multiple interactions ISO kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IFNG protein]; kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IFNG mRNA] CTD PMID:29355567 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IL1B protein]; kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL1B mRNA] CTD PMID:29355567 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IL6 protein]; kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IL6 mRNA] CTD PMID:29355567 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of NFKBIA protein] CTD PMID:29355567 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO kuwanon G results in increased expression of NR1H3 protein CTD PMID:29355567 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased phosphorylation of RELA protein] CTD PMID:29355567 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO kuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of TNF protein]; kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of TNF mRNA] CTD PMID:29355567 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        anti-inflammatory agent 14950
          kuwanone G 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  oxacycle 17185
                                    benzopyran 10135
                                      1-benzopyran 9851
                                        flavonoid 6374
                                          flavones 4166
                                            hydroxyflavone 4154
                                              tetrahydroxyflavone 642
                                                kuwanone G 12
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.