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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:6146
Term: kuwanone G
Definition: A tetrahydroxyflavone isolated from the root barks of Morus alba and has been shown to exhibit anti-inflammatory activity.
Chemical ID: MESH:C095194
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngmultiple interactionsISORGD:7374886480464CTDkuwanon G inhibits the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased expression of and results in increased secretion of IFNG protein], kuwanon G inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of IFNG mRNA]

PMID:29355567
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.