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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid
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Accession:CHEBI:46609 term browser browse the term
Definition:A phthalazine that has formula C19H12F3N3O3S.
Synonyms:xref_mesh: MESH:C067172


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(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B decreases activity
multiple interactions
ISO zopolrestat results in decreased activity of AKR1B1 protein
[zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased abundance of Reactive Oxygen Species]; [zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased secretion of Dinoprostone]; [zopolrestat results in decreased activity of AKR1B1 protein] which results in decreased susceptibility to Antigens, Plant
CTD PMID:21334316 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions
decreases activity
ISO zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; zopolrestat inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]
zopolrestat results in decreased activity of AKR1B10 protein; zopolrestat results in decreased activity of AKR1B10 protein mutant form
CTD PMID:18325492 PMID:19028477 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of CCL4 mRNA] CTD PMID:21334316 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of CCL5 mRNA] CTD PMID:21334316 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Il10 interleukin 10 multiple interactions ISO zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL10 mRNA] CTD PMID:21334316 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 multiple interactions ISO zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL13 mRNA] CTD PMID:21334316 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il18 interleukin 18 multiple interactions ISO zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL18 mRNA] CTD PMID:21334316 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il4 interleukin 4 multiple interactions ISO zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL4 mRNA] CTD PMID:21334316 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions ISO zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL5 mRNA] CTD PMID:21334316 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions ISO zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of IL6 mRNA]
zopolrestat inhibits the reaction [Antigens, Plant results in increased secretion of IL6 protein]
CTD PMID:21334316 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP zopolrestat results in decreased phosphorylation of and results in decreased activity of JAK2 protein CTD PMID:15746188 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] CTD PMID:24021941 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] CTD PMID:24021941 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein] CTD PMID:24021941 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions EXP zopolrestat results in decreased phosphorylation of and results in decreased activity of STAT5A protein CTD PMID:15746188 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO zopolrestat inhibits the reaction [Antigens, Plant results in increased expression of TNF mRNA]; zopolrestat inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein] CTD PMID:21334316 PMID:24021941 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    role 19714
      application 19403
        food additive 14927
          food acidity regulator 11719
            acetic acid 10857
              (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    p-block element atom 19657
                      carbon group element atom 19573
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18156
                                        monocarboxylic acid 17530
                                          acetic acid 10857
                                            (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid 16
paths to the root