CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: coumaphos
Accession: CHEBI:3903
browse the term
Definition: An organothiophosphate insecticide that has formula C14H16ClO5PS.
Synonyms: exact_synonym: O-(3-chloro-4-methyl-2-oxo-2H-chromen-7-yl) O,O-diethyl phosphorothioate
related_synonym: 3-Chloro-4-methyl-7-coumarinyl diethyl phosphorothioate; 3-Chloro-4-methyl-7-hydroxycoumarin diethyl thiophosphoric acid ester; 3-Chloro-7-diethoxyphosphinothioyloxy-4-methylcoumarin; 3-Chloro-7-hydroxy-4-methyl-coumarin O,O-diethyl phosphorothioate; Formula=C14H16ClO5PS; InChI=1S/C14H16ClO5PS/c1-4-17-21(22,18-5-2)20-10-6-7-11-9(3)13(15)14(16)19-12(11)8-10/h6-8H,4-5H2,1-3H3; InChIKey=BXNANOICGRISHX-UHFFFAOYSA-N; O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate; O,O-Diethyl O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl)phosphorothioate; O-(3-chloro-4-methyl-2-oxo-2H-chromen-7-yl) O,O-diethyl thiophosphate; Phosphorothioic acid, O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl ester; SMILES=CCOP(=S)(OCC)Oc1ccc2c(C)c(Cl)c(=O)oc2c1
xref: Beilstein:327083; CAS:56-72-4; KEGG:C11025; KEGG:D07750; LINCS:LSM-19025
xref_mesh: MESH:D003372
xref: VSDB:181
G
Ache
acetylcholinesterase
decreases activity
ISO
Coumaphos metabolite results in decreased activity of ACHE protein; Coumaphos results in decreased activity of ACHE protein
CTD
PMID:30625376 PMID:33844597
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
G
Ar
androgen receptor
multiple interactions
ISO
Coumaphos inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD
PMID:33049310
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Esr1
estrogen receptor 1
multiple interactions
ISO
Coumaphos binds to and results in increased activity of ESR1 protein
CTD
PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
multiple interactions
ISO
Coumaphos binds to and results in increased activity of ESR2 protein
CTD
PMID:33049310
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Gpat3
glycerol-3-phosphate acyltransferase 3
increases expression
ISO
Coumaphos results in increased expression of GPAT3 mRNA
CTD
PMID:26198647
NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
G
Lif
LIF, interleukin 6 family cytokine
increases expression
ISO
Coumaphos results in increased expression of LIF mRNA
CTD
PMID:26198647
NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
Coumaphos binds to and results in increased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
Coumaphos binds to and results in increased activity of PPARG protein
CTD
PMID:33049310
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Rara
retinoic acid receptor, alpha
increases activity
ISO
Coumaphos results in increased activity of RARA protein
CTD
PMID:20143881
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
G
Slc7a11
solute carrier family 7 member 11
increases expression
ISO
Coumaphos results in increased expression of SLC7A11 mRNA
CTD
PMID:26198647
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
G
Thrb
thyroid hormone receptor beta
multiple interactions
ISO
Coumaphos binds to and results in increased activity of THRB protein
CTD
PMID:33049310
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
G
Tp53
tumor protein p53
affects activity
ISO
Coumaphos metabolite affects the activity of TP53 protein
CTD
PMID:35435491
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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