Xanthatin - Ontology Report - Rat Genome Database

xanthatin results in decreased expression of CCNB1 mRNA

PMID:21568272

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

Cdc25c

cell division cycle 25C

decreases expression
multiple interactions

xanthatin results in decreased expression of CDC25C protein modified form
bafilomycin A1 inhibits the reaction [xanthatin results in decreased stability of CDC25C protein]; Go 6976 inhibits the reaction [xanthatin results in decreased stability of CDC25C protein]; leupeptin inhibits the reaction [xanthatin results in decreased stability of CDC25C protein]; TP53 protein promotes the reaction [xanthatin results in decreased expression of CDC25C protein modified form]; TP53 protein promotes the reaction [xanthatin results in decreased stability of CDC25C protein]; xanthatin results in increased ubiquitination of and results in decreased stability of CDC25C protein

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

Cdk1

cyclin-dependent kinase 1

decreases expression
multiple interactions
increases phosphorylation

xanthatin results in decreased expression of CDK1 mRNA
Go 6976 inhibits the reaction [xanthatin results in increased phosphorylation of CDK1 protein]

PMID:21568272 PMID:29074359

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

Chek1

checkpoint kinase 1

multiple interactions
affects phosphorylation

TP53 protein promotes the reaction [xanthatin results in decreased phosphorylation of CHEK1 protein]; xanthatin inhibits the reaction [Caffeine results in increased phosphorylation of CHEK1 protein]; xanthatin inhibits the reaction [Go 6976 results in increased phosphorylation of CHEK1 protein]
xanthatin affects the phosphorylation of CHEK1 protein

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

Fos

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [xanthatin results in increased expression of FOS]

PMID:23824011

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

Gadd45g

growth arrest and DNA-damage-inducible, gamma

multiple interactions
increases expression

[xanthatin results in decreased expression of TOP2A] which results in increased expression of GADD45G mRNA; [xanthatin results in increased expression of GADD45G mRNA] which results in increased abundance of Reactive Oxygen Species; Acetylcysteine inhibits the reaction [[xanthatin results in increased expression of GADD45G mRNA] which results in increased abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [xanthatin results in increased expression of GADD45G mRNA]; Acetylcysteine inhibits the reaction [xanthatin results in increased expression of GADD45G protein]
xanthatin results in increased expression of GADD45G mRNA; xanthatin results in increased expression of GADD45G protein

PMID:21568272 PMID:23313378 PMID:23824011

NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610

H2ax

H2A.X variant histone

increases expression

xanthatin results in increased expression of H2AX protein modified form

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

Hmox1

heme oxygenase 1

increases expression

xanthatin results in increased expression of HMOX1 mRNA

PMID:21568272

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Il1b

interleukin 1 beta

increases expression

xanthatin results in increased expression of IL1B mRNA

PMID:21568272

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Lamp1

lysosomal-associated membrane protein 1

increases expression

xanthatin results in increased expression of LAMP1 protein

NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883

Top2a

DNA topoisomerase II alpha

decreases activity
decreases expression
multiple interactions

xanthatin results in decreased activity of TOP2A protein
xanthatin results in decreased expression of TOP2A
[xanthatin results in decreased expression of TOP2A] which results in increased expression of GADD45G mRNA

PMID:23313378 PMID:23824011

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

Tp53

tumor protein p53

increases response to substance
multiple interactions

TP53 protein results in increased susceptibility to xanthatin
TP53 protein promotes the reaction [xanthatin results in decreased expression of CDC25C protein modified form]; TP53 protein promotes the reaction [xanthatin results in decreased phosphorylation of CHEK1 protein]; TP53 protein promotes the reaction [xanthatin results in decreased stability of CDC25C protein]