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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diphenylmethane-4,4'-diisocyanate
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Accession:CHEBI:53218 term browser browse the term
Definition:A diisocyanate consisting of diphenylmethane with two isocyanate groups at the 4- and 4'-positions.
Synonyms:related_synonym: 1,1'-Methylenebis(4-isocyanatobenzene);   4,4'-Diisocyanatodiphenylmethane;   4,4'-Methylenebis(phenyl isocyanate);   4,4'-Methylenedi(phenyl isocyanate);   4,4'-Methylenedi-p-phenylene diisocyanate;   4,4'-Methylenediphenyl diisocyanate;   4,4'-Methylenediphenyl isocyanate;   4,4'-Methylenediphenylene diisocyanate;   4,4'-Methylenediphenylene isocyanate;   4,4'-methylene diphenyl diisocyanate;   4-4'-Diisocyanate de diphenylmethane;   Bis(1,4-isocyanatophenyl)methane;   Bis(4-isocyanatophenyl)methane;   Bis(p-isocyanatophenyl)methane;   Bis(para-isocyanatophenyl)methane;   Diphenyl methane diisocyanate;   Diphenylmethan-4,4'-diisocyanat;   Diphenylmethane diisocyanate;   Diphenylmethyl diisocyanate;   Formula=C15H10N2O2;   InChI=1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2;   InChIKey=UPMLOUAZCHDJJD-UHFFFAOYSA-N;   MDI;   MDR;   Methylbisphenyl isocyanate;   Methylene bisphenyl isocyanate;   Methylene di-p-phenylene isocyanate;   Methylene diphenyl diisocyanate;   Methylenebis(4-isocyanatobenzene);   Methylenebis(4-phenyl isocyanate);   Methylenebis(4-phenylene isocyanate);   Methylenebis(p-phenyl isocyanate);   Methylenebis(p-phenylene isocyanate);   Methylenebis(para-phenyl isocyanate);   Methylenebis(para-phenylene isocyanate);   Methylenebisphenyl diisocyanate;   Methylenedi-p-phenylene diisocyanate;   Methylenedi-para-phenylene diisocyanate;   SMILES=O=C=Nc1ccc(Cc2ccc(cc2)N=C=O)cc1;   p,p'-Diphenylmethane diisocyanate;   p,p'-Methylenebis(phenyl isocyanate);   para,para'-Diphenylmethane diisocyanate;   para,para'-Methylenebis(phenyl isocyanate)
 xref: CAS:101-68-8;   Gmelin:166464;   KEGG:C19453
 xref_mesh: MESH:C005969
 xref: PMID:11927838;   PMID:1447476;   PMID:14531868;   PMID:17042142;   PMID:17336832;   PMID:18352975;   PMID:18418755;   PMID:18484168;   PMID:18787742;   PMID:19014769;   PMID:19191163;   PMID:19732394;   PMID:19757291;   PMID:20165612;   PMID:20933064;   PMID:21414210;   PMID:21878336;   PMID:21987383;   PMID:24572447;   PMID:26337647;   PMID:26690039;   PMID:26954368;   PMID:6296214;   PMID:6821040;   PMID:8093967;   PMID:8711735;   PMID:8960156;   Patent:WO2010121997;   Reaxys:797662;   Wikipedia:Diphenylmethane_diisocyanate


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diphenylmethane-4,4'-diisocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
affects binding		 EXP
ISO		 [4,4'-diphenylmethane diisocyanate binds to ALB protein] which results in increased chemical synthesis of N6-(((4-(4-(acetylamino)benzyl)phenyl)amino)carbonyl)lysine; [4,4'-diphenylmethane diisocyanate binds to ALB protein] which results in increased chemical synthesis of N6-(((4-(4-aminobenzyl)phenyl)amino)carbonyl)lysine
[4,4'-diphenylmethane diisocyanate co-treated with Glutathione] binds to and results in increased metabolism of ALB protein		 CTD PMID:19928878 PMID:23791970 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cd86 CD86 molecule increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases response to substance ISO GSTM1 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of ICAM1 protein CTD PMID:11698162 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il10 interleukin 10 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL10 mRNA CTD PMID:16940033 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL13 mRNA CTD PMID:16940033 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il2 interleukin 2 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL2 protein CTD PMID:22381623 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 mRNA; 4,4'-diphenylmethane diisocyanate results in increased expression of IL4 protein CTD PMID:11708898 PMID:16940033 PMID:22381623 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il4r interleukin 4 receptor increases expression ISO 4,4'-diphenylmethane diisocyanate results in increased expression of IL4RA protein CTD PMID:22381623 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Mir206 microRNA 206 multiple interactions
decreases expression		 ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA CTD PMID:31609387 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Mir381 microRNA 381 multiple interactions
decreases expression		 ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA CTD PMID:31609387 NCBI chr 6:128,740,976...128,741,036 JBrowse link
G Nat1 N-acetyltransferase 1 increases response to substance ISO NAT1 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nat2 N-acetyltransferase 2 increases response to substance ISO NAT2 protein polymorphism results in increased susceptibility to 4,4'-diphenylmethane diisocyanate CTD PMID:11927838 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA; [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA
4,4'-diphenylmethane diisocyanate results in increased expression of NOS2 mRNA		 CTD PMID:31609387 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression
multiple interactions		 ISO 4,4'-diphenylmethane diisocyanate results in increased expression of PPP3CA mRNA
[[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR206] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA; [[4,4'-diphenylmethane diisocyanate results in decreased expression of MIR381] which results in increased expression of PPP3CA mRNA] which results in increased expression of NOS2 mRNA		 CTD PMID:31609387 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        hapten 3061
          diphenylmethane-4,4'-diisocyanate 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            organic molecule 19724
                              organic cyclic compound 19515
                                organic aromatic compound 19382
                                  diarylmethane 10758
                                    diphenylmethane 5557
                                      diphenylmethane-4,4'-diisocyanate 15
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