2,2,2-trichloroethanol - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	2,2,2-trichloroethanol	go back to main search page
Accession:	CHEBI:28094	browse the term
Definition:	A chloroethanol that has formula C2H3Cl3O.
Synonyms:	related_synonym:	2,2,2-trichloro-1-ethanol; Formula=C2H3Cl3O; InChI=1S/C2H3Cl3O/c3-2(4,5)1-6/h6H,1H2; InChIKey=KPWDGTGXUYRARH-UHFFFAOYSA-N; SMILES=OCC(Cl)(Cl)Cl; Trichloroethanol
	alt_id:	CHEBI:27098; CHEBI:9685
	xref:	Beilstein:1697495; CAS:115-20-8; Gmelin:2407; KEGG:C07490
	xref_mesh:	MESH:C005849
	xref:	UM-BBD_compID:c0015

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Genes (15)

2,2,2-trichloroethanol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 2

affects binding

2,2,2-trichloroethanol binds to ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

interleukin 1 alpha

increases expression

2,2,2-trichloroethanol results in increased expression of IL1A protein

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of IL1B protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression
multiple interactions

2,2,2-trichloroethanol results in increased expression of IL6 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [2,2,2-trichloroethanol results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

matrix metallopeptidase 9

increases expression
increases activity

2,2,2-trichloroethanol results in increased expression of MMP9 mRNA; 2,2,2-trichloroethanol results in increased expression of MMP9 protein
2,2,2-trichloroethanol results in increased activity of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

MYD88, innate immune signal transduction adaptor

multiple interactions

[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of MYD88 protein

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NFKB inhibitor alpha

multiple interactions

[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in decreased expression of NFKBIA protein

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

proteasome 20S subunit beta 8

multiple interactions

[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB8 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB8 protein]

NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283

G

proteasome 20S subunit beta 9

multiple interactions

[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB9 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB9 protein]

NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of and affects the localization of RELA protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of and affects the localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

transporter 1, ATP binding cassette subfamily B member

multiple interactions

[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TAP1 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TAP1 protein]

NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901

G

TIMP metallopeptidase inhibitor 1

increases expression

2,2,2-trichloroethanol results in increased expression of TIMP1 mRNA; 2,2,2-trichloroethanol results in increased expression of TIMP1 protein

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

toll-like receptor 2

multiple interactions

[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TLR2 protein

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

multiple interactions

[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TLR4 protein

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of TNF protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19890
chemical entity	19867
molecular entity	19867
polyatomic entity	19819
heteroatomic molecular entity	19776
halide	18680
organohalogen compound	18520
organochlorine compound	18321
chloroethanol	44
2,2,2-trichloroethanol	15
Path 2
Term	Annotations
CHEBI ontology	19890
subatomic particle	19867
composite particle	19888
hadron	19888
baryon	19888
nucleon	19867
atomic nucleus	19888
atom	19888
main group element atom	19806
p-block element atom	19806
chalcogen	19577
oxygen atom	19549
oxygen molecular entity	19529
hydroxides	19334
organic hydroxy compound	18963
alcohol	15714
primary alcohol	14665
ethanols	8821
chloroethanol	44
2,2,2-trichloroethanol	15

paths to the root