hydroperoxy polyunsaturated fatty acid - Ontology Report

GPX1 protein results in increased susceptibility to 12-HPETE

PMID:11115402

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

Gpx4

glutathione peroxidase 4

increases chemical synthesis

GPX4 protein results in increased chemical synthesis of 12-HPETE

PMID:11115402

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

Ptgs2

prostaglandin-endoperoxide synthase 2

multiple interactions

12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; 12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein]

PMID:12538810

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

13-HPODE

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Cat

catalase

increases expression

13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of CAT protein

PMID:10946007

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

Cav1

caveolin 1

increases expression

13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of CAV1 mRNA

PMID:27257344

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

Ccl2

C-C motif chemokine ligand 2

multiple interactions

[13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of CCL2 protein; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Egr1

early growth response 1

multiple interactions

[13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with 2-chloro-5-nitrobenzanilide] results in increased expression of EGR1 protein; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 mRNA; [13-hydroperoxy-9,11-octadecadienoic acid co-treated with MK-886] results in increased expression of EGR1 protein

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

Ppara

peroxisome proliferator activated receptor alpha

increases expression

13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

Pparg

peroxisome proliferator-activated receptor gamma

increases expression

13-hydroperoxy-9,11-octadecadienoic acid results in increased expression of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

9,10,13-TriHOME

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ephx3

epoxide hydrolase 3

multiple interactions

[EPHX3 gene mutant form results in decreased hydrolysis of Epoxy Compounds] results in decreased abundance of [9,10,13-trihydroxy-11-octadecenoic acid binds to Ceramides]; [EPHX3 gene mutant form results in decreased hydrolysis of Epoxy Compounds] which results in decreased chemical synthesis of 9,10,13-trihydroxy-11-octadecenoic acid

PMID:33334892

NCBI chr 7:11,206,812...11,212,122
Ensembl chr 7:11,206,812...11,212,122

linoleic acid hydroperoxide

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Agt

angiotensinogen

multiple interactions
increases lipidation

Ascorbic Acid promotes the reaction [linoleic acid hydroperoxide results in increased lipidation of AGT protein modified form]

PMID:26111765

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

Cygb

cytoglobin

increases metabolic processing

CYGB protein results in increased metabolism of linoleic acid hydroperoxide

PMID:11320098

NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442

Gpx1

glutathione peroxidase 1

increases reduction

GPX1 protein results in increased reduction of linoleic acid hydroperoxide

PMID:8428933

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

Gpx2

glutathione peroxidase 2

increases reduction

GPX2 protein results in increased reduction of linoleic acid hydroperoxide