Ephx3 (epoxide hydrolase 3) - Rat Genome Database

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Gene: Ephx3 (epoxide hydrolase 3) Rattus norvegicus
Analyze
Symbol: Ephx3
Name: epoxide hydrolase 3
RGD ID: 1307206
Description: Predicted to enable epoxide hydrolase activity. Predicted to be involved in epoxide metabolic process. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human EPHX3 (epoxide hydrolase 3); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Abhd9; abhydrolase domain containing 9; LOC366836
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,857,367 - 11,862,674 (-)NCBIGRCr8
mRatBN7.2711,206,812 - 11,212,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl711,206,812 - 11,212,122 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx714,025,716 - 14,030,967 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,903,125 - 15,908,378 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,774,664 - 13,779,923 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0714,212,470 - 14,217,778 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,212,470 - 14,217,778 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0714,368,238 - 14,374,218 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,762,797 - 12,768,105 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,763,131 - 12,768,081 (-)NCBI
Celera79,319,072 - 9,324,380 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:22798687  


Genomics

Comparative Map Data
Ephx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8711,857,367 - 11,862,674 (-)NCBIGRCr8
mRatBN7.2711,206,812 - 11,212,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl711,206,812 - 11,212,122 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx714,025,716 - 14,030,967 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,903,125 - 15,908,378 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0713,774,664 - 13,779,923 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0714,212,470 - 14,217,778 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl714,212,470 - 14,217,778 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0714,368,238 - 14,374,218 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,762,797 - 12,768,105 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1712,763,131 - 12,768,081 (-)NCBI
Celera79,319,072 - 9,324,380 (-)NCBICelera
Cytogenetic Map7q11NCBI
EPHX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381915,226,919 - 15,237,008 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1915,226,919 - 15,233,435 (-)EnsemblGRCh38hg38GRCh38
GRCh371915,337,730 - 15,343,779 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361915,198,730 - 15,204,231 (-)NCBINCBI36Build 36hg18NCBI36
Build 341915,198,730 - 15,204,231NCBI
Celera1915,233,387 - 15,239,517 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,905,834 - 14,911,965 (-)NCBIHuRef
CHM1_11915,337,209 - 15,343,353 (-)NCBICHM1_1
T2T-CHM13v2.01915,351,830 - 15,358,380 (-)NCBIT2T-CHM13v2.0
Ephx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391732,402,742 - 32,408,444 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1732,402,744 - 32,408,523 (-)EnsemblGRCm39 Ensembl
GRCm381732,183,770 - 32,189,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1732,183,770 - 32,189,549 (-)EnsemblGRCm38mm10GRCm38
MGSCv371732,320,715 - 32,326,408 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361731,912,476 - 31,918,169 (-)NCBIMGSCv36mm8
Celera1733,102,260 - 33,107,957 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.39NCBI
Ephx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,996,221 - 8,003,557 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554957,995,979 - 8,001,423 (+)NCBIChiLan1.0ChiLan1.0
EPHX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22020,140,523 - 20,147,906 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11919,143,313 - 19,150,698 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01914,759,671 - 14,766,596 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11915,746,332 - 15,750,027 (-)NCBIpanpan1.1PanPan1.1panPan2
EPHX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12046,932,984 - 46,935,635 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2046,932,945 - 46,937,858 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2046,778,851 - 46,783,281 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02047,417,823 - 47,422,253 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2047,417,709 - 47,422,231 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12046,652,580 - 46,657,009 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02047,069,195 - 47,073,624 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02047,342,838 - 47,347,267 (+)NCBIUU_Cfam_GSD_1.0
Ephx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118205,698,305 - 205,703,601 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365965,247,388 - 5,252,737 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365965,247,529 - 5,252,740 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl262,348,957 - 62,353,106 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1262,348,531 - 62,353,118 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2261,925,875 - 61,930,728 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPHX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,824,112 - 13,827,220 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660745,670,897 - 5,677,461 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ephx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249012,337,363 - 2,343,653 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249012,339,127 - 2,344,592 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ephx3
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:166
Count of miRNA genes:114
Interacting mature miRNAs:131
Transcripts:ENSRNOT00000038961
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat

Markers in Region
AI179290  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2711,206,537 - 11,206,699 (+)MAPPERmRatBN7.2
Rnor_6.0714,212,196 - 14,212,357NCBIRnor6.0
Rnor_5.0714,368,282 - 14,368,443UniSTSRnor5.0
RGSC_v3.4712,762,523 - 12,762,684UniSTSRGSC3.4
Celera79,318,798 - 9,318,959UniSTS
RH 3.4 Map765.2UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 9 11 1 2 17 13 11 1
Below cutoff 3 34 34 20 8 20 7 9 54 34 22 7

Sequence


RefSeq Acc Id: ENSRNOT00000038961   ⟹   ENSRNOP00000030761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl711,206,812 - 11,212,122 (-)Ensembl
Rnor_6.0 Ensembl714,212,470 - 14,217,778 (-)Ensembl
RefSeq Acc Id: NM_001108988   ⟹   NP_001102458
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8711,857,367 - 11,862,674 (-)NCBI
mRatBN7.2711,206,812 - 11,212,122 (-)NCBI
Rnor_6.0714,212,470 - 14,217,778 (-)NCBI
Rnor_5.0714,368,238 - 14,374,218 (-)NCBI
RGSC_v3.4712,762,797 - 12,768,105 (-)RGD
Celera79,319,072 - 9,324,380 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102458 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89461 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030761
  ENSRNOP00000030761.4
RefSeq Acc Id: NP_001102458   ⟸   NM_001108988
- UniProtKB: D4A4W4 (UniProtKB/TrEMBL),   A6K941 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030761   ⟸   ENSRNOT00000038961
Protein Domains
AB hydrolase-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A4W4-F1-model_v2 AlphaFold D4A4W4 1-415 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307206 AgrOrtholog
BioCyc Gene G2FUF-34831 BioCyc
Ensembl Genes ENSRNOG00000027319 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038961 ENTREZGENE
  ENSRNOT00000038961.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/TrEMBL
  Epox_hydrolase-like UniProtKB/TrEMBL
KEGG Report rno:366836 UniProtKB/TrEMBL
NCBI Gene 366836 ENTREZGENE
PANTHER EPOXIDE HYDROLASE UniProtKB/TrEMBL
  EPOXIDE HYDROLASE 3 UniProtKB/TrEMBL
Pfam Abhydrolase_6 UniProtKB/TrEMBL
PhenoGen Ephx3 PhenoGen
PRINTS EPOXHYDRLASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027319 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A6K941 ENTREZGENE, UniProtKB/TrEMBL
  D4A4W4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-05-06 Ephx3  epoxide hydrolase 3  Abhd9  abhydrolase domain containing 9   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Abhd9  abhydrolase domain containing 9   Abhd9_predicted  abhydrolase domain containing 9 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Abhd9_predicted  abhydrolase domain containing 9 (predicted)      Symbol and Name status set to approved 70820 APPROVED