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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:HPETE
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Accession:CHEBI:24644 term browser browse the term
Definition:Mono-hydroperoxy (e)icosatetraenoic acids (HPETEs) are the primary products of lipoxygenase-catalysed oxygenation of arachidonic acid.
Synonyms:related_synonym: HPETEs;   Mono-hydroperoxy icosatetraenoic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:59720


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12(S)-HPETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpx1 glutathione peroxidase 1 increases response to substance ISO GPX1 protein results in increased susceptibility to 12-HPETE CTD PMID:11115402 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx4 glutathione peroxidase 4 increases chemical synthesis ISO GPX4 protein results in increased chemical synthesis of 12-HPETE CTD PMID:11115402 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; 12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein] CTD PMID:12538810 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      atom 19819
        nonmetal atom 19707
          carbon atom 19630
            organic molecular entity 19630
              fatty acid derivative 1042
                icosanoid 457
                  HPETE 3
                    11(R)-HPETE 0
                    12(R)-HPETE + 0
                    12(S)-HPETE + 3
                    12-HPETE 2-glyceryl ester 0
                    15(R)-HPETE 0
                    15-HPETE + 0
                    15S-HpEPE 0
                    5-HPETE + 0
                    5S-HpEPE 0
                    5S-Hydroperoxy-18R-HEPE 0
                    8(R)-HPETE 0
                    8(S)-HPETE 0
                    9-HPETE + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          fatty acid 16008
                                            fatty acid derivative 1042
                                              icosanoid 457
                                                HPETE 3
                                                  11(R)-HPETE 0
                                                  12(R)-HPETE + 0
                                                  12(S)-HPETE + 3
                                                  12-HPETE 2-glyceryl ester 0
                                                  15(R)-HPETE 0
                                                  15-HPETE + 0
                                                  15S-HpEPE 0
                                                  5-HPETE + 0
                                                  5S-HpEPE 0
                                                  5S-Hydroperoxy-18R-HEPE 0
                                                  8(R)-HPETE 0
                                                  8(S)-HPETE 0
                                                  9-HPETE + 0
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