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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:HPETE
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Accession:CHEBI:24644 term browser browse the term
Definition:Mono-hydroperoxy (e)icosatetraenoic acids (HPETEs) are the primary products of lipoxygenase-catalysed oxygenation of arachidonic acid.
Synonyms:related_synonym: HPETEs;   Mono-hydroperoxy icosatetraenoic acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:59720


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12(S)-HPETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpx1 glutathione peroxidase 1 increases response to substance ISO GPX1 protein results in increased susceptibility to 12-HPETE CTD PMID:11115402 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx4 glutathione peroxidase 4 increases chemical synthesis ISO GPX4 protein results in increased chemical synthesis of 12-HPETE CTD PMID:11115402 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 12-HPETE inhibits the reaction [Sodium Salicylate inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]]; 12-HPETE inhibits the reaction [Sodium Salicylate results in decreased activity of PTGS2 protein] CTD PMID:12538810 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    chemical entity 19791
      atom 19788
        nonmetal atom 19662
          carbon atom 19560
            organic molecular entity 19560
              fatty acid derivative 1023
                icosanoid 454
                  HPETE 3
                    11(R)-HPETE 0
                    12(R)-HPETE + 0
                    12(S)-HPETE + 3
                    12-HPETE 2-glyceryl ester 0
                    15(R)-HPETE 0
                    15-HPETE + 0
                    5-HPETE + 0
                    5S-Hydroperoxy-18R-HEPE 0
                    8(R)-HPETE 0
                    8(S)-HPETE 0
                    9-HPETE + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      carboxylic acid 18079
                                        monocarboxylic acid 17425
                                          fatty acid 15860
                                            fatty acid derivative 1023
                                              icosanoid 454
                                                HPETE 3
                                                  11(R)-HPETE 0
                                                  12(R)-HPETE + 0
                                                  12(S)-HPETE + 3
                                                  12-HPETE 2-glyceryl ester 0
                                                  15(R)-HPETE 0
                                                  15-HPETE + 0
                                                  5-HPETE + 0
                                                  5S-Hydroperoxy-18R-HEPE 0
                                                  8(R)-HPETE 0
                                                  8(S)-HPETE 0
                                                  9-HPETE + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.