Abcg2 (ATP binding cassette subfamily G member 2) - Rat Genome Database

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Gene: Abcg2 (ATP binding cassette subfamily G member 2) Rattus norvegicus
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Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2
RGD ID: 631345
Description: Enables several functions, including cytoskeletal protein binding activity; efflux transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to estradiol stimulus; and embryonic process involved in female pregnancy. Located in external side of apical plasma membrane. Biomarker of diabetes mellitus; secondary hyperparathyroidism; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (JR blood group)); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; erlotinib pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ATP binding cassette subfamily G member 2 (Junior blood group); ATP-binding cassette protein G2; ATP-binding cassette sub-family G member 2; ATP-binding cassette, sub-family G (WHITE), member 2; ATP-binding cassette, subfamily G (WHITE), member 2; Bcrp; BCRP1; breast cancer resistance protein 1 homolog; broad substrate specificity ATP-binding cassette transporter ABCG2; urate exporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: Abcg2em1Sage
Genetic Models: SD-Abcb1aem1Sage Abcg2em1Sage ; SD-Abcg2em1Sage
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8489,006,056 - 89,132,915 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl489,005,969 - 89,132,493 (+)EnsemblGRCr8
mRatBN7.2487,676,241 - 87,802,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl487,745,319 - 87,802,409 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx492,961,189 - 93,018,372 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0488,736,572 - 88,793,756 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0487,105,627 - 87,162,776 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0488,765,441 - 88,890,268 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl488,832,178 - 88,890,621 (+)Ensemblrn6Rnor6.0
Rnor_5.04153,587,206 - 153,712,481 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4487,502,584 - 87,560,017 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera482,507,731 - 82,564,802 (+)NCBICelera
RGSC_v3.1487,747,008 - 87,804,442 (+)NCBI
Cytogenetic Map4q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-Hydroxypyrene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2',5'-Dihydroxychalcone  (ISO)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-methylcholanthrene  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylumbelliferone  (ISO)
4-nonylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azaorotic acid  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methoxypsoralen  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6alpha-methylprednisolone  (ISO)
7-Hydroxymethotrexate  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (ISO)
abacavir  (ISO)
Abemaciclib  (ISO)
actinomycin D  (ISO)
acyclovir  (ISO)
aflatoxin B1  (EXP,ISO)
albendazole S-oxide  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-Zearalanol  (EXP)
AM-251  (ISO)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
anandamide  (ISO)
androst-4-ene-3,17-dione  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
Azaspiracid  (ISO)
azathioprine  (EXP)
Azoxymethane  (ISO)
beclomethasone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoylhypaconine  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bis-4-nitrophenyl phosphate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carboplatin  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin  (EXP,ISO)
cimetidine  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
corticosterone  (ISO)
crizotinib  (ISO)
curcumin  (ISO)
cyazofamid  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dabrafenib  (ISO)
daidzein  (ISO)
Danofloxacin  (ISO)
dantrolene  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
deoxycholic acid  (ISO)
depsipeptide  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzoylmethane  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dieldrin  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
Diferuloylputrescine  (EXP)
digoxin  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
Dimethyl phthalate  (ISO)
dioxygen  (ISO)
disodium cromoglycate  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
E3040  (ISO)
elemental selenium  (ISO)
enasidenib  (ISO)
endosulfan  (EXP,ISO)
erlotinib hydrochloride  (ISO)
estriol  (ISO)
estrone  (ISO)
estrone 3-sulfate  (ISO)
ethanol  (EXP,ISO)
ethirimol  (ISO)
etoposide  (ISO)
eugenol  (EXP)
eupatilin  (EXP)
everolimus  (ISO)
Finrozole  (ISO)
flavone  (ISO)
flavones  (ISO)
flupyradifurone  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP,ISO)
glutathione  (ISO)
glyburide  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
haloperidol  (ISO)
heptachlor  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
Hypaconitine  (ISO)
hypoxanthine  (EXP,ISO)
indole-3-methanol  (ISO)
indoxyl sulfate  (ISO)
inulin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
ketoconazole  (EXP)
kynurenic acid  (ISO)
L-methionine  (EXP,ISO)
lapatinib  (ISO)
lead diacetate  (EXP)
ledipasvir  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lucifer yellow dye  (ISO)
lupeol  (ISO)
luteolin  (ISO)
LY294002  (ISO)
MeIQx  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
Mesaconitine  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methylmercury chloride  (EXP,ISO)
metiram  (ISO)
metronidazole  (ISO)
mifepristone  (ISO)
milbemycin  (ISO)
mitoxantrone  (ISO)
Mitragynine  (ISO)
MK 571  (ISO)
mometasone furoate  (ISO)
monepantel  (ISO)
morphine  (EXP)
N-benzoylglycine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodimethylamine  (ISO)
naloxone  (EXP)
naproxen  (ISO)
NCX-4040  (ISO)
nefazodone  (ISO)
nelfinavir  (ISO)
neomycin  (ISO)
nicotine  (ISO)
nilotinib  (ISO)
nimesulide  (ISO)
nitrofen  (EXP)
nitrofurantoin  (EXP,ISO)
notoginsenoside R1  (EXP,ISO)
novobiocin  (EXP,ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oltipraz  (ISO)
omeprazole  (ISO)
oroxylin A  (ISO)
oxaliplatin  (EXP)
oxfendazole  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paliperidone palmitate  (ISO)
panobinostat  (ISO)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pheophorbide a  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
porphyrins  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (EXP,ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
prazosin  (ISO)
probenecid  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
pterostilbene  (ISO)
purines  (EXP)
quercetin  (EXP,ISO)
quetiapine fumarate  (ISO)
reserpine  (ISO)
resmethrin  (ISO)
resveratrol  (ISO)
rhodamine 123  (ISO)
rifampicin  (ISO)
risperidone  (ISO)
rosuvastatin calcium  (EXP,ISO)
rotenone  (EXP)
SB 431542  (ISO)
SCH 23390  (EXP)
selenium atom  (ISO)
sildenafil citrate  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium hydrogencarbonate  (EXP)
Soman  (EXP)
stilben-4-ol  (ISO)
streptozocin  (ISO)
sulfapyridine  (ISO)
sulfasalazine  (ISO)
sulindac sulfide  (ISO)
sulpiride  (ISO)
sunitinib  (EXP,ISO)
Sunset Yellow FCF  (ISO)
tadalafil  (EXP)
tamoxifen  (ISO)
tartrazine  (ISO)
taurocholic acid  (ISO)
taxane  (ISO)
tectochrysin  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
toluene  (EXP)
topotecan  (EXP,ISO)
trans-piceid  (ISO)
triamcinolone  (ISO)
triamterene  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vancomycin  (ISO)
venetoclax  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
warfarin  (ISO)
WIN 55212-2  (ISO)
XMU-MP-1  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
asymmetric cell division  (ISO)
biotin transport  (ISO,ISS)
canonical Wnt signaling pathway  (ISO)
cardiac cell fate specification  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle tissue regeneration  (ISO)
cardiac ventricle development  (ISO)
cell fate specification  (ISO)
cell population proliferation  (ISO)
cellular detoxification  (ISO)
cellular homeostasis  (ISO)
cellular response to dexamethasone stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to prolactin  (ISO)
circadian rhythm  (ISO)
cognition  (ISO)
collagen biosynthetic process  (ISO)
connective tissue replacement  (ISO)
connective tissue replacement involved in inflammatory response wound healing  (ISO)
determination of adult lifespan  (ISO)
embryonic heart tube development  (ISO)
embryonic process involved in female pregnancy  (IDA)
endothelial cell apoptotic process  (ISO)
endothelial cell migration  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
export across plasma membrane  (IDA,ISO)
female gonad development  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
gene expression  (ISO)
glutathione transport  (ISO)
Harderian gland development  (ISO)
heart capillary growth  (ISO)
heart development  (ISO)
heart morphogenesis  (ISO)
hematopoietic stem cell differentiation  (ISO)
heme biosynthetic process  (ISO)
inflammatory response  (ISO)
kynurenic acid metabolic process  (ISO)
L-tryptophan metabolic process  (ISO)
lipid oxidation  (ISO)
lipid transport  (IEA)
macrophage differentiation  (ISO)
memory  (ISO)
mesenchymal stem cell differentiation  (ISO)
mesenchymal stem cell proliferation  (ISO)
mitochondrial fission  (ISO)
mitochondrion organization  (ISO)
myofibroblast differentiation  (ISO)
negative regulation of intestinal absorption  (IMP)
neural tissue regeneration  (ISO)
neurogenesis  (ISO)
nucleoside transport  (ISO)
organic anion transport  (IDA,IEA)
pericyte cell differentiation  (ISO)
porphyrin-containing compound metabolic process  (ISO)
proteasomal protein catabolic process  (ISO)
protein acetylation  (ISO)
protein-containing complex assembly  (IDA)
protoporphyrinogen IX metabolic process  (ISO)
reactive oxygen species biosynthetic process  (ISO)
renal urate salt excretion  (IEP,ISO)
response to 2,3,7,8-tetrachlorodibenzodioxine  (IEP)
response to alcohol  (IEP)
response to bleomycin  (ISO)
response to decreased oxygen levels  (ISO)
response to folic acid  (IEP)
response to hypoxia  (ISO)
response to insulin  (IEP)
response to iron ion  (IEP)
response to light stimulus  (ISO)
response to lipopolysaccharide  (IEP)
response to oxidative stress  (ISO)
response to paraquat  (ISO)
response to toxic substance  (ISO)
response to transforming growth factor beta  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
riboflavin transport  (ISO,ISS)
sulfate transmembrane transport  (ISO)
sulfite export across plasma membrane  (ISO)
tetrapyrrole metabolic process  (ISO)
tissue homeostasis  (ISO)
tissue remodeling  (ISO)
toxin metabolic process  (ISO)
transepithelial transport  (ISO)
transmembrane transport  (IBA,IMP,ISO,ISS)
transport across blood-brain barrier  (ISO)
tube formation  (ISO)
urate biosynthetic process  (ISO)
urate metabolic process  (ISO)
urate transport  (IMP)
vasculogenesis  (ISO)
wound healing  (ISO)
xenobiotic detoxification by transmembrane export across the plasma membrane  (IDA,ISO)
xenobiotic transport  (ISO)
xenobiotic transport across blood-brain barrier  (IC,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2. null
2. Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen. Adachi Y, etal., Mol Pharmacol. 2005 Mar;67(3):923-8. Epub 2004 Dec 14.
3. Gene specific epigenetic regulation of hepatic folate transport system is responsible for perturbed cellular folate status during aging and exogenous modulation. Ahmad Najar R, etal., Mol Nutr Food Res. 2016 Jun;60(6):1501-13. doi: 10.1002/mnfr.201500991. Epub 2016 Apr 21.
4. Association of genotypes and haplotypes of multi-drug transporter genes ABCB1 and ABCG2 with clinical response to imatinib mesylate in chronic myeloid leukemia patients. Au A, etal., Biomed Pharmacother. 2014 Apr;68(3):343-9. doi: 10.1016/j.biopha.2014.01.009. Epub 2014 Feb 7.
5. Coexpression of Multiple ABC-Transporters is Strongly Associated with Treatment Response in Childhood Acute Myeloid Leukemia. Bartholomae S, etal., Pediatr Blood Cancer. 2016 Feb;63(2):242-7. doi: 10.1002/pbc.25785. Epub 2015 Oct 29.
6. A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk. Campa D, etal., Int J Cancer. 2012 Aug 15;131(4):803-12. doi: 10.1002/ijc.26436. Epub 2011 Nov 28.
7. Identification of a novel, tissue-specific ABCG2 promoter expressed in pediatric acute megakaryoblastic leukemia. Campbell PK, etal., Leuk Res. 2011 Oct;35(10):1321-9. doi: 10.1016/j.leukres.2011.05.004.
8. ABC transporter function and regulation at the blood-spinal cord barrier. Campos CR, etal., J Cereb Blood Flow Metab. 2012 Aug;32(8):1559-66. doi: 10.1038/jcbfm.2012.47. Epub 2012 Apr 4.
9. Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum. Collins JF, etal., Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G964-71. Epub 2005 Jan 6.
10. Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat. Cygalova L, etal., Toxicol Lett. 2008 May 30;178(3):176-80. Epub 2008 Mar 21.
11. High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients. Delord M, etal., Oncotarget. 2013 Oct;4(10):1582-91.
12. Synergistic interaction of ABCB1 and ABCG2 polymorphisms predicts the prevalence of toxic encephalopathy during anticancer chemotherapy. Erdilyi DJ, etal., Pharmacogenomics J. 2008 Oct;8(5):321-7.
13. Expression of the breast cancer resistance protein in breast cancer. Faneyte IF, etal., Clin Cancer Res. 2002 Apr;8(4):1068-74.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. The antiepileptic drugs phenobarbital and carbamazepine reduce transport of methotrexate in rat choroid plexus by down-regulation of the reduced folate carrier. Halwachs S, etal., Mol Pharmacol. 2011 Oct;80(4):621-9. doi: 10.1124/mol.111.072421. Epub 2011 Jul 7.
16. Alcohol and Cocaine Exposure Modulates ABCB1 and ABCG2 Transporters in Male Alcohol-Preferring Rats. Hammad AM, etal., Mol Neurobiol. 2019 Mar;56(3):1921-1932. doi: 10.1007/s12035-018-1153-2. Epub 2018 Jul 6.
17. Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s). Hori S, etal., J Neurochem 2004 Aug;90(3):526-36.
18. Selective gene silencing of rat ATP-binding cassette G2 transporter in an in vitro blood-brain barrier model by short interfering RNA. Hori S, etal., J Neurochem. 2005 Apr;93(1):63-71. doi: 10.1111/j.1471-4159.2004.02994.x.
19. Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2. Hosomi A, etal., PLoS One. 2012;7(2):e30456. doi: 10.1371/journal.pone.0030456. Epub 2012 Feb 10.
20. Decreased urinary secretion of belotecan in folic acid-induced acute renal failure rats due to down-regulation of Oat1 and Bcrp. Jin QR, etal., Xenobiotica. 2009 Oct;39(10):711-21.
21. Association of the BCRP C421A polymorphism with nonpapillary renal cell carcinoma. Korenaga Y, etal., Int J Cancer. 2005 Nov 10;117(3):431-4.
22. Impaired expression and function of breast cancer resistance protein (Bcrp) in brain cortex of streptozocin-induced diabetic rats. Liu YC, etal., Biochem Pharmacol. 2007 Dec 15;74(12):1766-72. Epub 2007 Aug 21.
23. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier. Narang VS, etal., Am J Physiol Cell Physiol. 2008 Aug;295(2):C440-50. Epub 2008 Jun 4.
26. Estrogen receptor alpha induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells. Oda K, etal., J Pharm Sci. 2013 Sep;102(9):3364-72. doi: 10.1002/jps.23549. Epub 2013 Apr 16.
27. Post-transcriptional regulation of breast cancer resistance protein after intestinal ischemia-reperfusion. Ogura J, etal., Biol Pharm Bull. 2008 May;31(5):1032-5.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. Effect of endotoxin on the expression of placental drug transporters and glyburide disposition in pregnant rats. Petrovic V, etal., Drug Metab Dispos. 2008 Sep;36(9):1944-50. Epub 2008 May 27.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
33. Breast cancer resistance protein regulates apical ectoplasmic specialization dynamics stage specifically in the rat testis. Qian X, etal., Am J Physiol Endocrinol Metab. 2013 Apr 1;304(7):E757-69. doi: 10.1152/ajpendo.00645.2012. Epub 2013 Feb 12.
34. GOA pipeline RGD automated data pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Roberts LM, etal., Neuroscience. 2008 Aug 13;155(2):423-38. Epub 2008 Jun 13.
38. Evaluation of intestinal absorption of amtolmetin guacyl in rats: breast cancer resistant protein as a primary barrier of oral bioavailability. Rong Z, etal., Life Sci. 2013 Feb 27;92(3):245-51. doi: 10.1016/j.lfs.2012.12.010. Epub 2013 Jan 16.
39. Concurrent effects of ABCB1 C3435T, ABCG2 C421A, and XRCC1 Arg194Trp genetic polymorphisms with risk of cancer, clinical output, and response to treatment with imatinib mesylate in patients with chronic myeloid leukemia. Salimizand H, etal., Tumour Biol. 2016 Jan;37(1):791-8. doi: 10.1007/s13277-015-3874-4. Epub 2015 Aug 7.
40. Expression of the BCRP gene (ABCG2/MXR/ABCP) in childhood acute lymphoblastic leukaemia. Sauerbrey A, etal., Br J Haematol. 2002 Jul;118(1):147-50.
41. Hepatic oval cells have the side population phenotype defined by expression of ATP-binding cassette transporter ABCG2/BCRP1. Shimano K, etal., Am J Pathol 2003 Jul;163(1):3-9.
42. Expression and transport activity of breast cancer resistance protein (Bcrp/Abcg2) in dually perfused rat placenta and HRP-1 cell line. Staud F, etal., J Pharmacol Exp Ther. 2006 Oct;319(1):53-62. Epub 2006 Jun 29.
43. BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia. Steinbach D, etal., Leukemia. 2002 Aug;16(8):1443-7.
44. Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism. Sugimoto R, etal., Kidney Int. 2017 Mar;91(3):658-670. doi: 10.1016/j.kint.2016.09.041. Epub 2016 Dec 15.
45. Breast cancer resistance protein (BCRP/MXR/ABCG2) in adult acute lymphoblastic leukaemia: frequent expression and possible correlation with shorter disease-free survival. Suvannasankha A, etal., Br J Haematol. 2004 Nov;127(4):392-8.
46. Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
47. ABCG2 expression, function, and promoter methylation in human multiple myeloma. Turner JG, etal., Blood. 2006 Dec 1;108(12):3881-9. Epub 2006 Aug 17.
48. Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant-induced arthritis rat. Uno S, etal., Biopharm Drug Dispos. 2009 Jan;30(1):49-54.
49. Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats. van Vliet EA, etal., Epilepsia. 2005 Oct;46(10):1569-80.
50. Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Woodward OM, etal., Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10338-42. doi: 10.1073/pnas.0901249106. Epub 2009 Jun 8.
51. Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes. Xu D, etal., Acta Pharmacol Sin. 2014 Sep;35(9):1215-25. doi: 10.1038/aps.2014.39. Epub 2014 Aug 25.
52. Target therapy of multiple myeloma by PTX-NPs and ABCG2 antibody in a mouse xenograft model. Yang C, etal., Oncotarget. 2015 Sep 29;6(29):27714-24. doi: 10.18632/oncotarget.4663.
53. Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/COX-2 activation. Yousif S, etal., J Neurochem. 2012 Nov;123(4):491-503. doi: 10.1111/j.1471-4159.2012.07890.x. Epub 2012 Sep 3.
54. Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion. Yue W, etal., Mol Pharm. 2009 Jan-Feb;6(1):134-43.
55. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. Zamek-Gliszczynski MJ, etal., Drug Metab Dispos. 2012 Sep;40(9):1825-33. doi: 10.1124/dmd.112.046508. Epub 2012 Jun 18.
Additional References at PubMed
PMID:9861027   PMID:12429862   PMID:12477932   PMID:12958161   PMID:16244436   PMID:16870176   PMID:17098188   PMID:17145775   PMID:17380269   PMID:17437964   PMID:17635990   PMID:17669244  
PMID:18378562   PMID:18834626   PMID:18841445   PMID:19503597   PMID:19541926   PMID:20053405   PMID:20216549   PMID:20399185   PMID:20460386   PMID:21075088   PMID:21106720   PMID:21775706  
PMID:21803024   PMID:22393122   PMID:22869929   PMID:22998451   PMID:23306951   PMID:23584883   PMID:24342797   PMID:25539457   PMID:25868844   PMID:26119820   PMID:26252052   PMID:26364927  
PMID:26467765   PMID:26727197   PMID:27180978   PMID:27616577   PMID:28554189   PMID:28577929   PMID:28623970   PMID:29610494   PMID:30405239   PMID:31983315   PMID:33558655   PMID:33790363  
PMID:34255797   PMID:35345975  


Genomics

Comparative Map Data
Abcg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8489,006,056 - 89,132,915 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl489,005,969 - 89,132,493 (+)EnsemblGRCr8
mRatBN7.2487,676,241 - 87,802,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl487,745,319 - 87,802,409 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx492,961,189 - 93,018,372 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0488,736,572 - 88,793,756 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0487,105,627 - 87,162,776 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0488,765,441 - 88,890,268 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl488,832,178 - 88,890,621 (+)Ensemblrn6Rnor6.0
Rnor_5.04153,587,206 - 153,712,481 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4487,502,584 - 87,560,017 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera482,507,731 - 82,564,802 (+)NCBICelera
RGSC_v3.1487,747,008 - 87,804,442 (+)NCBI
Cytogenetic Map4q24NCBI
ABCG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38488,090,264 - 88,231,626 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl488,090,150 - 88,231,818 (-)Ensemblhg38GRCh38
GRCh37489,011,416 - 89,152,778 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36489,230,440 - 89,299,035 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34489,370,018 - 89,436,901NCBI
Celera486,303,350 - 86,371,627 (-)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef484,757,887 - 84,903,974 (-)NCBIHuRef
CHM1_1488,988,243 - 89,128,985 (-)NCBICHM1_1
T2T-CHM13v2.0491,416,761 - 91,562,592 (-)NCBIT2T-CHM13v2.0
Abcg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39658,561,476 - 58,669,436 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl658,561,508 - 58,672,661 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38658,584,491 - 58,692,451 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl658,584,523 - 58,695,676 (+)Ensemblmm10GRCm38
MGSCv37658,546,666 - 58,642,445 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36658,526,250 - 58,622,029 (+)NCBIMGSCv36mm8
Celera660,752,972 - 60,848,739 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.82NCBI
Abcg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547412,355,731 - 12,408,969 (+)Ensembl
ChiLan1.0NW_00495547412,365,903 - 12,408,715 (+)NCBIChiLan1.0ChiLan1.0
ABCG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2386,093,103 - 86,236,613 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1486,353,103 - 86,499,020 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0480,379,108 - 80,446,641 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1491,101,321 - 91,170,418 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl491,101,321 - 91,170,157 (-)EnsemblpanPan2panpan1.1
ABCG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13211,443,778 - 11,517,674 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3211,443,780 - 11,517,674 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3230,372,283 - 30,510,869 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03211,496,580 - 11,635,323 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3211,496,586 - 11,573,345 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13211,580,165 - 11,719,079 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03211,406,011 - 11,544,317 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03228,508,945 - 28,549,001 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
UU_Cfam_GSD_1.03228,373,259 - 28,501,671 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
ABCG2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8130,775,444 - 130,945,393 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18130,853,414 - 130,945,388 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,193,291 - 140,228,765 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1736,458,110 - 36,599,753 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603715,206,025 - 15,348,744 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Abcg2
1088 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:64
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000009546
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)480216705104243248Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48279077797183061Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat

Markers in Region
AI428558  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2487,802,161 - 87,802,259 (+)MAPPERmRatBN7.2
Rnor_6.0488,890,021 - 88,890,118NCBIRnor6.0
Rnor_5.04153,711,881 - 153,711,978UniSTSRnor5.0
RGSC_v3.4487,559,770 - 87,559,867UniSTSRGSC3.4
Celera482,564,555 - 82,564,652UniSTS
Cytogenetic Map4q24UniSTS
RH130231  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2487,802,540 - 87,802,720 (+)MAPPERmRatBN7.2
Rnor_6.0488,890,400 - 88,890,579NCBIRnor6.0
Rnor_5.04153,712,260 - 153,712,439UniSTSRnor5.0
RGSC_v3.4487,560,149 - 87,560,328UniSTSRGSC3.4
Celera482,564,934 - 82,565,113UniSTS
RH 3.4 Map4541.5UniSTS
Cytogenetic Map4q24UniSTS
RH143656  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8489,126,149 - 89,126,260 (+)Marker Load Pipeline
mRatBN7.2487,795,997 - 87,796,107 (+)MAPPERmRatBN7.2
Rnor_6.0488,883,857 - 88,883,966NCBIRnor6.0
Rnor_5.04153,705,717 - 153,705,826UniSTSRnor5.0
RGSC_v3.4487,553,606 - 87,553,715UniSTSRGSC3.4
Celera482,558,391 - 82,558,500UniSTS
RH 3.4 Map4541.5UniSTS
Cytogenetic Map4q24UniSTS


Genetic Models
This gene Abcg2 is modified in the following models/strains:
SD-Abcb1aem1Sage Abcg2em1Sage     SD-Abcg2em1Sage    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 141 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_181381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB094089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB105817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY089996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY089997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY089998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY274118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000009546   ⟹   ENSRNOP00000009546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl489,005,969 - 89,132,493 (+)Ensembl
mRatBN7.2 Ensembl487,745,319 - 87,802,409 (+)Ensembl
Rnor_6.0 Ensembl488,834,066 - 88,890,268 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088983   ⟹   ENSRNOP00000075138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl488,832,178 - 88,890,621 (+)Ensembl
RefSeq Acc Id: NM_181381   ⟹   NP_852046
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8489,075,474 - 89,132,562 (+)NCBI
mRatBN7.2487,745,319 - 87,802,409 (+)NCBI
Rnor_6.0488,834,066 - 88,890,268 (+)NCBI
Rnor_5.04153,587,206 - 153,712,481 (+)NCBI
RGSC_v3.4487,502,584 - 87,560,017 (+)RGD
Celera482,507,731 - 82,564,802 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236573   ⟹   XP_006236635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8489,078,280 - 89,132,915 (+)NCBI
mRatBN7.2487,748,089 - 87,802,757 (+)NCBI
Rnor_6.0488,837,278 - 88,890,209 (+)NCBI
Rnor_5.04153,587,206 - 153,712,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236576   ⟹   XP_006236638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8489,006,403 - 89,132,915 (+)NCBI
mRatBN7.2487,676,241 - 87,802,757 (+)NCBI
Rnor_6.0488,765,441 - 88,890,209 (+)NCBI
Rnor_5.04153,587,206 - 153,712,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592620   ⟹   XP_017448109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8489,082,638 - 89,132,915 (+)NCBI
mRatBN7.2487,755,294 - 87,802,757 (+)NCBI
Rnor_6.0488,843,594 - 88,890,209 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107562   ⟹   XP_038963490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8489,019,097 - 89,132,915 (+)NCBI
mRatBN7.2487,688,949 - 87,802,757 (+)NCBI
RefSeq Acc Id: XM_063286042   ⟹   XP_063142112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8489,006,056 - 89,132,915 (+)NCBI
RefSeq Acc Id: NP_852046   ⟸   NM_181381
- UniProtKB: Q80W57 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236638   ⟸   XM_006236576
- Peptide Label: isoform X1
- UniProtKB: Q80UR3 (UniProtKB/Swiss-Prot),   Q80ST1 (UniProtKB/Swiss-Prot),   Q80XF3 (UniProtKB/Swiss-Prot),   Q80W57 (UniProtKB/Swiss-Prot),   A6K137 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236635   ⟸   XM_006236573
- Peptide Label: isoform X1
- UniProtKB: Q80UR3 (UniProtKB/Swiss-Prot),   Q80ST1 (UniProtKB/Swiss-Prot),   Q80XF3 (UniProtKB/Swiss-Prot),   Q80W57 (UniProtKB/Swiss-Prot),   A6K137 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448109   ⟸   XM_017592620
- Peptide Label: isoform X1
- UniProtKB: Q80UR3 (UniProtKB/Swiss-Prot),   Q80ST1 (UniProtKB/Swiss-Prot),   Q80XF3 (UniProtKB/Swiss-Prot),   Q80W57 (UniProtKB/Swiss-Prot),   A6K137 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009546   ⟸   ENSRNOT00000009546
Ensembl Acc Id: ENSRNOP00000075138   ⟸   ENSRNOT00000088983
RefSeq Acc Id: XP_038963490   ⟸   XM_039107562
- Peptide Label: isoform X1
- UniProtKB: Q80W57 (UniProtKB/Swiss-Prot),   Q80UR3 (UniProtKB/Swiss-Prot),   Q80ST1 (UniProtKB/Swiss-Prot),   Q80XF3 (UniProtKB/Swiss-Prot),   A6K137 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142112   ⟸   XM_063286042
- Peptide Label: isoform X1
- UniProtKB: Q80XF3 (UniProtKB/Swiss-Prot),   Q80W57 (UniProtKB/Swiss-Prot),   Q80UR3 (UniProtKB/Swiss-Prot),   Q80ST1 (UniProtKB/Swiss-Prot),   A6K137 (UniProtKB/TrEMBL)
Protein Domains
ABC transmembrane type-2   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80W57-F1-model_v2 AlphaFold Q80W57 1-657 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693086
Promoter ID:EPDNEW_R3611
Type:multiple initiation site
Name:Abcg2_1
Description:ATP binding cassette subfamily G member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0488,834,048 - 88,834,108EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631345 AgrOrtholog
BioCyc Gene G2FUF-44660 BioCyc
Ensembl Genes ENSRNOG00000007041 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009546 ENTREZGENE
  ENSRNOT00000009546.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC_2_trans UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABCG_dom UniProtKB/Swiss-Prot
  ABCG_transporters UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:312382 UniProtKB/Swiss-Prot
NCBI Gene 312382 ENTREZGENE
PANTHER ABC TRANSPORTER G FAMILY MEMBER 28 UniProtKB/Swiss-Prot
  BROAD SUBSTRATE SPECIFICITY ATP-BINDING CASSETTE TRANSPORTER ABCG2 UniProtKB/Swiss-Prot
Pfam ABC2_membrane UniProtKB/Swiss-Prot
  ABC2_membrane_7 UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
PharmGKB ABCG2 RGD
PhenoGen Abcg2 PhenoGen
PROSITE ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007041 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A6K137 ENTREZGENE, UniProtKB/TrEMBL
  ABCG2_RAT UniProtKB/Swiss-Prot
  Q80ST1 ENTREZGENE
  Q80UR3 ENTREZGENE
  Q80W57 ENTREZGENE
  Q80XF3 ENTREZGENE
UniProt Secondary Q80ST1 UniProtKB/Swiss-Prot
  Q80UR3 UniProtKB/Swiss-Prot
  Q80XF3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-16 Abcg2  ATP-binding cassette, subfamily G (WHITE), member 2  Abcg2  ATP-binding cassette, sub-family G (WHITE), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Slc1a7  ATP-binding cassette, sub-family G (WHITE), member 2  Abcg2  ATP-binding cassette protein G2  Name updated to reflect Human and Mouse nomenclature 625702 APPROVED