GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcg2 | decreases methylation | ISO | ABCG2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased methylation of ABCG2 5' UTR | PMID:27901495 | Abcg2 | increases activity | ISO | ABCG2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased activity of ABCG2 protein | PMID:27475308 | Abcg2 | increases expression | ISO | ABCG2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of ABCG2 mRNA; Benzo(a)pyrene results in increased expression of ABCG2 protein | PMID:15917307 PMID:20106945 PMID:20403331 PMID:21632981 PMID:22316170 PMID:22912337 PMID:26238291 PMID:32717239 | Abcg2 | increases methylation | ISO | Abcg2 (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of ABCG2 intron | PMID:27901495 | Abcg2 | increases transport | ISO | ABCG2 (Homo sapiens) | 6480464 | CTD | ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite | PMID:15917307 | Abcg2 | increases transport | ISO | Abcg2 (Mus musculus) | 6480464 | CTD | ABCG2 protein results in increased transport of Benzo(a)pyrene; ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite | PMID:25451572 | Abcg2 | multiple interactions | ISO | ABCG2 (Homo sapiens) | 6480464 | CTD | 6,2',4'-trimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of ABCG2 protein]; [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Ethanol co-treated with Benzo(a)pyrene]] which results in increased expression of ABCG2 mRNA; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased transport of Benzo(a)pyrene metabolite; [Ethanol co-treated with Benzo(a)pyrene] results in increased expression of ABCG2 mRNA; benzo(k)fluoranthene promotes the reaction [ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite]; indolo(3,2-b)carbazole promotes the reaction [ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite]; N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Benzo(a)pyrene results in increased expression of ABCG2 protein]; oltipraz promotes the reaction [ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite] | PMID:15917307 PMID:22912337 PMID:35412187 | | ||||||||||||||||||||||
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