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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2
Acc ID: CHEBI:71415
Term: nitrofurantoin
Definition: An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.
Chemical ID: MESH:D009582
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg2affects abundanceEXP 6480464CTDABCG2 protein affects the abundance of NitrofurantoinPMID:18799806
Abcg2affects response to substanceEXP 6480464CTDABCG2 affects the susceptibility to NitrofurantoinPMID:19105722
Abcg2increases secretionEXP 6480464CTDABCG2 results in increased secretion of NitrofurantoinPMID:19105722
Abcg2multiple interactionsEXP 6480464CTDchrysin inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]; Elacridar inhibits the reaction [ABCG2 protein affects the transport of Nitrofurantoin]PMID:18799806 PMID:19732493
Abcg2affects abundanceISOAbcg2 (Mus musculus)6480464CTDABCG2 protein affects the abundance of NitrofurantoinPMID:17785426
Abcg2affects transportISOABCG2 (Homo sapiens)6480464CTDABCG2 protein affects the transport of NitrofurantoinPMID:15709111
Abcg2affects transportISOAbcg2 (Mus musculus)6480464CTDABCG2 protein affects the transport of NitrofurantoinPMID:15709111 PMID:15722455
Abcg2increases exportISOAbcg2 (Mus musculus)6480464CTDABCG2 protein results in increased export of NitrofurantoinPMID:15709111
Abcg2increases secretionISOAbcg2 (Mus musculus)6480464CTDABCG2 protein results in increased secretion of NitrofurantoinPMID:15709111
Abcg2increases transportISOABCG2 (Homo sapiens)6480464CTDABCG2 protein results in increased transport of NitrofurantoinPMID:17093006
Abcg2increases transportISOAbcg2 (Mus musculus)6480464CTDABCG2 protein results in increased transport of NitrofurantoinPMID:17093006
Abcg2multiple interactionsISOABCG2 (Homo sapiens)6480464CTDchrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]; Nitrofurantoin inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]PMID:17093006 PMID:26907376
Abcg2multiple interactionsISOAbcg2 (Mus musculus)6480464CTDchrysin inhibits the reaction [ABCG2 protein results in increased transport of Nitrofurantoin]PMID:17093006
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