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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg2decreases activityISOABCG2 (Homo sapiens)6480464CTDperfluorooctanoic acid results in decreased activity of ABCG2 proteinPMID:23435180 PMID:24014645
Abcg2increases expressionISOABCG2 (Homo sapiens)6480464CTDperfluorooctanoic acid results in increased expression of ABCG2 mRNAPMID:35548680
Abcg2increases expressionISOAbcg2 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of ABCG2 mRNA; perfluorooctanoic acid results in increased expression of ABCG2 proteinPMID:23435180
Abcg2increases transportISOABCG2 (Homo sapiens)6480464CTDABCG2 protein results in increased transport of perfluorooctanoic acidPMID:24014645
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