Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg2multiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCG2 protein]PMID:24945792
Abcg2affects response to substanceISOABCG2 (Homo sapiens)6480464CTDABCG2 affects the susceptibility to fulvestrantPMID:24169358
Abcg2multiple interactionsISOABCG2 (Homo sapiens)6480464CTDFulvestrant affects the reaction [4-nonylphenol results in decreased expression of ABCG2 protein]; Fulvestrant affects the reaction [bisphenol A results in decreased expression of ABCG2 protein]; Fulvestrant affects the reaction [Estradiol results in decreased expression of ABCG2 protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA]; Fulvestrant inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 protein]; Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of ABCG2 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in decreased expression of ABCG2 protein]; Fulvestrant inhibits the reaction [Estriol results in increased expression of ABCG2 mRNA]; Fulvestrant inhibits the reaction [Estriol results in increased expression of ABCG2 protein]; Fulvestrant inhibits the reaction [Genistein results in decreased expression of ABCG2 protein]PMID:17823853 PMID:26850786 PMID:27036933 PMID:34537452
Go Back to source page   Continue to Ontology report