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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg2decreases activityISOABCG2 (Homo sapiens)6480464CTDTestosterone results in decreased activity of ABCG2 proteinPMID:22581381
Abcg2increases expressionISOAbcg2 (Mus musculus)6480464CTDTestosterone results in increased expression of ABCG2 mRNAPMID:21669218
Abcg2multiple interactionsISOABCG2 (Homo sapiens)6480464CTD[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA; [Estradiol co-treated with Testosterone] results in increased expression of ABCG2 protein; ESR1 protein promotes the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA]; Flutamide inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA]; Flutamide inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA]; Fulvestrant inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 protein]; Testosterone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate]PMID:17823853 PMID:22581381
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