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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631345 Species: Rattus norvegicus RGD Object: Gene Symbol: Abcg2 Name: ATP-binding cassette, subfamily G (WHITE), member 2

Acc ID: CHEBI:17347 Term: testosterone Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5. CasRN: 58-22-0 Chemical ID: MESH:D013739

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1551496	6480464	CTD	Testosterone results in increased expression of ABCG2 mRNA	PMID:21669218
multiple interactions	ISO	RGD:1352615	6480464	CTD	ESR1 protein promotes the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA] [Estradiol co-treated with Testosterone] results in increased expression of ABCG2 protein Flutamide inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA] fulvestrant inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA] Flutamide inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 protein] fulvestrant inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 protein]	PMID:17823853