GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcg2 | decreases activity | ISO | ABCG2 (Homo sapiens) | 6480464 | CTD | Testosterone results in decreased activity of ABCG2 protein | PMID:22581381 | Abcg2 | increases expression | ISO | Abcg2 (Mus musculus) | 6480464 | CTD | Testosterone results in increased expression of ABCG2 mRNA | PMID:21669218 | Abcg2 | multiple interactions | ISO | ABCG2 (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA; [Estradiol co-treated with Testosterone] results in increased expression of ABCG2 protein; ESR1 protein promotes the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA]; Flutamide inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA]; Flutamide inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 protein]; Fulvestrant inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 mRNA]; Fulvestrant inhibits the reaction [[Estradiol co-treated with Testosterone] results in increased expression of ABCG2 protein]; Testosterone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate] | PMID:17823853 PMID:22581381 | |
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