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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg2affects response to substanceISOABCG2 (Homo sapiens)6480464CTDABCG2 protein affects the susceptibility to DoxorubicinPMID:18382425
Abcg2affects transportISOABCG2 (Homo sapiens)6480464CTDABCG2 protein affects the transport of DoxorubicinPMID:17273774
Abcg2decreases response to substanceISOABCG2 (Homo sapiens)6480464CTDABCG2 protein results in decreased susceptibility to DoxorubicinPMID:17938326
Abcg2increases exportISOABCG2 (Homo sapiens)6480464CTDABCG2 protein results in increased export of DoxorubicinPMID:27816545
Abcg2increases expressionISOABCG2 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of ABCG2 mRNA; Doxorubicin results in increased expression of ABCG2 proteinPMID:18382425 PMID:20019844
Abcg2multiple interactionsISOABCG2 (Homo sapiens)6480464CTD[[Gefitinib results in decreased activity of EGFR protein] which affects the localization of ABCG2 protein] which results in decreased export of Doxorubicin; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Doxorubicin; [Paclitaxel results in decreased expression of ABCG2] which results in decreased susceptibility to Doxorubicin; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Doxorubicin]; ABCG2 results in decreased abundance of and results in decreased susceptibility to Doxorubicin; abemaciclib inhibits the reaction [ABCG2 protein results in increased export of Doxorubicin]; Dactinomycin inhibits the reaction [Doxorubicin results in increased expression of ABCG2 mRNA]; Gefitinib inhibits the reaction [ABCG2 protein results in decreased susceptibility to Doxorubicin]; Sunitinib inhibits the reaction [ABCG2 results in decreased abundance of and results in decreased susceptibility to Doxorubicin]PMID:17938326 PMID:19232821 PMID:20019844 PMID:21712253 PMID:21833476 PMID:27816545
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