Abcg2<sup>em1Sage</sup> (ATP-binding cassette, subfamily G (WHITE), member 2; ZFN induced mutatn 1, Sage) - Rat Genome Database

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Gene: Abcg2em1Sage (ATP-binding cassette, subfamily G (WHITE), member 2; ZFN induced mutatn 1, Sage) Rattus norvegicus
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Symbol: Abcg2em1Sage
Name: ATP-binding cassette, subfamily G (WHITE), member 2; ZFN induced mutatn 1, Sage
RGD ID: 12904064
Description: This ZFN mutant allelic contain a 588-bp deletion within Abcg2 gene , resulting knockout of protein expression via Western blot.
ASSOCIATED WITH abnormal xenobiotic pharmacokinetics
Type: allele  of Abcg2  
Previously known as: Abcg2 tm1sage; Abcg2^[em1Sage]; Abcg2em1Sage; ATP-binding cassette, subfamily G (WHITE), member 2; endonuclease induced mutatn 1, Sage; Bcrp Knockout
Is Marker For: Strains:   SD-Abcg2em1Sage   SD-Abcb1aem1Sage Abcg2em1Sage  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data curation from Horizon Discovery Data curation from Horizon Discovery (https://www.horizondiscovery.com/)
2. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. Zamek-Gliszczynski MJ, etal., Drug Metab Dispos. 2012 Sep;40(9):1825-33. doi: 10.1124/dmd.112.046508. Epub 2012 Jun 18.

Genomics


Related Rat Strains
The following Strains have been annotated to Abcg2em1Sage
SD-Abcb1aem1Sage Abcg2em1Sage     SD-Abcg2em1Sage    


Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-20 Abcg2em1Sage  ATP-binding cassette, subfamily G (WHITE), member 2; ZFN induced mutatn 1, Sage  Abcg2em1Sage  ATP-binding cassette, subfamily G (WHITE), member 2; endonuclease induced mutatn 1, Sage  Name changed 629549 APPROVED