Kcnh2 (potassium voltage-gated channel subfamily H member 2) - Rat Genome Database

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Gene: Kcnh2 (potassium voltage-gated channel subfamily H member 2) Rattus norvegicus
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Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
RGD ID: 621414
Description: Enables inward rectifier potassium channel activity and scaffold protein binding activity. Involved in potassium ion transport; regulation of membrane potential; and spinal cord development. Predicted to be located in cell surface and perinuclear region of cytoplasm. Predicted to be part of inward rectifier potassium channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eag-related protein 1; ERG-1; ERG1; ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related protein 1; potassium channel, voltage gated eag related subfamily H, member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2; r-ERG; RERG; voltage-gated inwardly rectifying potassium channel KCNH2; voltage-gated potassium channel subunit Kv11.1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,719,357 - 11,751,424 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl411,692,980 - 11,751,421 (+)EnsemblGRCr8
mRatBN7.2410,826,834 - 10,859,009 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,826,928 - 10,859,008 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx415,973,605 - 16,005,332 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,793,792 - 11,825,521 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,145,580 - 10,177,308 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,355,066 - 7,387,282 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,355,574 - 7,387,253 (+)Ensemblrn6Rnor6.0
Rnor_5.047,366,726 - 7,398,606 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.446,192,644 - 6,224,285 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera46,444,570 - 6,473,521 (+)NCBICelera
RGSC_v3.146,192,643 - 6,224,284 (+)NCBI
Cytogenetic Map4q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-butaclamol  (ISO)
(-)-lobeline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-duloxetine hydrochloride  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
(Z)-chlorprothixene  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine  (ISO)
1,3-diphenylguanidine  (ISO)
1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethyl-2-butanol  (ISO)
1-[10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-2-phenothiazinyl]ethanone  (ISO)
1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine  (ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
10H-phenothiazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2-diphenylacetic acid (1-ethyl-3-piperidinyl) ester  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-[(3-butyl-1-isoquinolinyl)oxy]-N,N-dimethylethanamine  (ISO)
2-[2-(diethylamino)ethylamino]-2-phenylacetic acid 3-methylbutyl ester  (ISO)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (ISO)
2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxy-2,2-diphenylacetic acid 2-(diethylamino)ethyl ester  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3-diphenyl-N-(1-phenylethyl)-1-propanamine  (ISO)
3,4-dimethoxybenzoic acid 4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl ester  (ISO)
3,6-diaminoacridine  (ISO)
3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1H-benzimidazol-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (ISO)
4-amino-5-chloro-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
4-aminopyridine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole  (ISO)
7H-xanthine  (ISO)
9H-xanthine  (ISO)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (ISO)
acetylmethadol  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ajmaline  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpidem  (ISO)
alverine  (ISO)
amantadine  (ISO)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amorolfine  (ISO)
amperozide  (ISO)
amphetamine  (EXP)
amsacrine  (ISO)
aprindine  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
Arkin (TN)  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
astemizole  (EXP,ISO)
atorvastatin calcium  (EXP)
ATP  (ISO)
atrazine  (ISO)
azaperone  (ISO)
Azaspiracid  (ISO)
azelastine  (ISO)
Azimilide  (ISO)
Azoxymethane  (ISO)
Balofloxacin  (ISO)
benzalkonium chloride  (ISO)
benzatropine  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester  (ISO)
benzydamine  (ISO)
bepridil  (ISO)
berberine  (EXP)
betahistine  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
bopindolol  (ISO)
brefeldin A  (ISO)
bromhexine  (ISO)
Bromocyclen  (ISO)
Bromperidol  (ISO)
brompheniramine  (ISO)
buclizine  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
butoconazole  (ISO)
C3-thiacarbocyanine cation  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cantharidin  (ISO)
carbachol  (ISO)
carbinoxamine  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
casticin  (ISO)
cefotetan  (ISO)
cepharanthine  (ISO)
cetalkonium chloride  (ISO)
CGP 52608  (ISO)
chloramine T  (ISO)
chlordecone  (ISO)
chlorobutanol  (ISO)
chloroform  (ISO)
chlorphenamine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
cibenzoline  (ISO)
ciclopirox  (ISO)
cinacalcet  (ISO)
cinchocaine  (ISO)
cinchonine  (ISO)
ciprofloxacin  (ISO)
cisapride  (ISO)
cisplatin  (ISO)
clarithromycin  (ISO)
clemastine  (ISO)
clofazimine  (ISO)
clofedanol  (ISO)
clomipramine  (ISO)
clopenthixol  (ISO)
clorotepine  (ISO)
Clotiapine  (ISO)
clotrimazole  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
codeine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
crizotinib  (ISO)
crystal violet  (ISO)
curcumin  (ISO)
cyamemazine  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
Danofloxacin  (ISO)
dantrolene  (ISO)
danuglipron  (ISO)
darifenacin  (ISO)
daunorubicin  (ISO)
DDT  (ISO)
denopamine  (ISO)
deptropine  (ISO)
desipramine  (ISO)
desloratadine  (ISO)
desmethylastemizole  (ISO)
dexbrompheniramine  (ISO)
dexetimide  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
Didecyldimethylammonium  (ISO)
difloxacin  (ISO)
digoxin  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dioxygen  (EXP)
diphenylpyraline  (ISO)
dipyridamole  (ISO)
disopyramide  (ISO)
dithiazanine  (ISO)
dobutamine  (ISO)
dofetilide  (ISO)
dolasetron  (ISO)
Domiphen bromide  (ISO)
domperidone  (ISO)
doxepin  (ISO)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
droperidol  (ISO)
dutasteride  (ISO)
dyclonine  (ISO)
E-4031  (EXP,ISO)
Ebastine  (ISO)
Eburnamonine  (ISO)
econazole  (ISO)
eletriptan  (ISO)
eliprodil  (ISO)
emedastine  (ISO)
endosulfan  (EXP)
enoxacin  (ISO)
enrofloxacin  (ISO)
epinastine  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (ISO)
ethanol  (ISO)
ezogabine  (ISO)
Febantel  (ISO)
fenoverine  (ISO)
fentanyl  (ISO)
Fexofenadine hydrochloride  (ISO)
fingolimod hydrochloride  (ISO)
flavonoids  (EXP)
flecainide  (ISO)
fleroxacin  (ISO)
flufenamic acid  (ISO)
fluorescein (lactone form)  (ISO)
fluoxetine  (ISO)
flupenthixol  (ISO)
flurazepam  (ISO)
fluvoxamine  (ISO)
fomocaine  (ISO)
formoterol fumarate  (ISO)
fulvestrant  (ISO)
gabapentin  (ISO)
gatifloxacin  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
ginsenoside Rb1  (ISO)
ginsenoside Rf  (ISO)
ginsenoside Rg1  (ISO)
glucose  (EXP,ISO)
glyburide  (ISO)
Grepafloxacin  (ISO)
Halofantrine  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
hydroxyzine  (ISO)
ibogaine  (ISO)
ICI 118551  (ISO)
idarubicin  (ISO)
imipramine  (EXP,ISO)
ipriflavone  (ISO)
isoconazole  (ISO)
ivabradine  (ISO)
ketoconazole  (ISO)
lamotrigine  (ISO)
lenperone  (ISO)
lidocaine  (ISO)
Liranaftate  (ISO)
lofepramine  (ISO)
lomefloxacin  (ISO)
loratadine  (ISO)
lovastatin  (ISO)
loxapine  (ISO)
lubeluzole  (ISO)
malachite green cation  (ISO)
manidipine  (ISO)
Maprotiline  (ISO)
Mebhydrolin napadisilate  (ISO)
mefloquine  (ISO)
mepyramine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mesoridazine  (ISO)
methadone  (ISO)
methapyrilene  (ISO)
methdilazine  (ISO)
methiothepin  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
metixene  (ISO)
metoclopramide  (ISO)
metoprolol  (ISO)
mexiletine  (ISO)
Mibefradil  (ISO)
miconazole  (ISO)
mitoxantrone  (ISO)
Mitragynine  (ISO)
Mizolastine  (ISO)
moxifloxacin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine  (ISO)
nadifloxacin  (ISO)
naftifine  (ISO)
nefazodone  (ISO)
nicotine  (ISO)
Nifekalant  (ISO)
Niflumic acid  (ISO)
Niguldipine  (ISO)
nilotinib  (ISO)
nimesulide  (ISO)
nimodipine  (EXP)
Nitrovin  (ISO)
norfloxacin  (ISO)
Norfluoxetine  (ISO)
nortriptyline  (ISO)
ofloxacin  (ISO)
olanzapine  (ISO)
oligomycin B  (ISO)
Orbifloxacin  (ISO)
ouabain  (ISO)
oxeladin  (ISO)
oxiconazole  (ISO)
oxybuprocaine  (ISO)
Oxyphencyclimine  (ISO)
paliperidone palmitate  (ISO)
palonosetron  (ISO)
Panaxadiol  (ISO)
Panaxatriol  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
parathiazine  (ISO)
pecazine  (ISO)
pefloxacin  (ISO)
pentamidine  (ISO)
pentanal  (ISO)
pentobarbital  (ISO)
perfluorooctanoic acid  (ISO)
perhexiline  (ISO)
Perhexiline maleate  (ISO)
periciazine  (ISO)
perphenazine  (ISO)
phentolamine  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
pimobendan  (ISO)
pimozide  (ISO)
pizotifen  (ISO)
potassium atom  (ISO)
Prenylamine  (ISO)
pridinol  (ISO)
probucol  (ISO)
procainamide  (ISO)
profenamine  (ISO)
progesterone  (EXP)
promazine  (ISO)
propafenone  (ISO)
propanal  (ISO)
propranolol  (ISO)
pyridine  (ISO)
pyruvic acid  (ISO)
pyrvinium  (ISO)
quetiapine fumarate  (ISO)
quifenadine  (ISO)
quinacrine  (ISO)
quinidine  (ISO)
quinine  (ISO)
ractopamine  (ISO)
radicicol  (ISO)
ranolazine  (ISO)
reactive oxygen species  (ISO)
rescinnamine  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
risperidone  (ISO)
ritanserin  (ISO)
Robenidine  (ISO)
rolipram  (ISO)
rose bengal  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (EXP,ISO)
rotigotine  (ISO)
rubidium atom  (ISO)
Salmeterol xinafoate  (ISO)
sarin  (EXP)
sertaconazole  (ISO)
sertindole  (ISO)
sertraline  (ISO)
simvastatin  (EXP)
SNC-80  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium cyanide  (ISO)
sorafenib  (ISO)
sotalol  (ISO)
strychnine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Syrosingopine  (ISO)
tacrine  (ISO)
tamoxifen  (ISO)
tazarotene  (ISO)
terbinafine  (ISO)
terconazole  (ISO)
Terfenadine  (ISO)
terodiline  (ISO)
testosterone  (ISO)
tetramethrin  (ISO)
thallium atom  (ISO)
thioridazine  (ISO)
tiamulin  (ISO)
tifenamil  (ISO)
tipepidine  (ISO)
tiquizium bromide  (ISO)
titanium dioxide  (ISO)
tolcapone  (ISO)
topiramate  (ISO)
toremifene  (ISO)
trazodone  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trifluoperazine  (ISO)
trifluperidol  (ISO)
triflupromazine  (ISO)
Tripelennamine  (ISO)
triphenyl phosphate  (ISO)
triprolidine  (ISO)
triptonide  (ISO)
Triton X-100  (ISO)
Valnemulin  (ISO)
valproic acid  (EXP,ISO)
vandetanib  (ISO)
vanoxerine dihydrochloride  (ISO)
venlafaxine hydrochloride  (ISO)
verapamil  (ISO)
vincamine  (ISO)
Vinpocetine  (ISO)
vitamin E  (ISO)
xaliproden  (ISO)
zimeldine  (ISO)
zinc pyrithione  (ISO)
ziprasidone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. RERG is a molecular correlate of the inward-rectifying K current in clonal rat pituitary cells. Bauer CK, etal., Receptors Channels 1998;6(1):19-29.
2. Regulation of an ERG K+ current by Src tyrosine kinase. Cayabyab FS and Schlichter LC, J Biol Chem 2002 Apr 19;277(16):13673-81.
3. Expression of the IKr components KCNH2 (rERG) and KCNE2 (rMiRP1) during late rat heart development. Chun KR, etal., Exp Mol Med. 2004 Aug 31;36(4):367-71.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2. Guo J, etal., J Biol Chem. 2012 Sep 28;287(40):33132-41. Epub 2012 Aug 9.
7. Fast erg K+ currents in rat embryonic serotonergic neurones. Hirdes W, etal., J Physiol. 2005 Apr 1;564(Pt 1):33-49. Epub 2005 Jan 27.
8. Short QT syndrome and atrial fibrillation caused by mutation in KCNH2. Hong K, etal., J Cardiovasc Electrophysiol. 2005 Apr;16(4):394-6.
9. The regulation of the cardiac potassium channel (HERG) by caveolin-1. Lin J, etal., Biochem Cell Biol. 2008 Oct;86(5):405-15. doi: 10.1139/o08-118.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Identification of two nervous system-specific members of the erg potassium channel gene family. Shi W, etal., J Neurosci 1997 Dec 15;17(24):9423-32.
19. Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing. Tester DJ, etal., Heart Rhythm. 2005 May;2(5):507-17.
20. Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers. Wimmers S, etal., Pflugers Arch. 2001 Jan;441(4):450-5.
21. Tissue and species distribution of mRNA for the IKr-like K+ channel, erg. Wymore RS, etal., Circ Res 1997 Feb;80(2):261-8.
Additional References at PubMed
PMID:7604285   PMID:7736582   PMID:7889573   PMID:8587608   PMID:8995352   PMID:9351446   PMID:9351462   PMID:10718922   PMID:10843886   PMID:11953308   PMID:14525949   PMID:14668215  
PMID:14670813   PMID:16339175   PMID:17322986   PMID:19913309   PMID:19921238   PMID:20605793   PMID:21063088   PMID:21463633   PMID:21536673   PMID:23589291   PMID:24931372   PMID:25281747  
PMID:27071825   PMID:28280240   PMID:29507111   PMID:29949809   PMID:30544220   PMID:32388931   PMID:32559772   PMID:33263944   PMID:33426760   PMID:35841324   PMID:38063256  


Genomics

Comparative Map Data
Kcnh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,719,357 - 11,751,424 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl411,692,980 - 11,751,421 (+)EnsemblGRCr8
mRatBN7.2410,826,834 - 10,859,009 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,826,928 - 10,859,008 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx415,973,605 - 16,005,332 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,793,792 - 11,825,521 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,145,580 - 10,177,308 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,355,066 - 7,387,282 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,355,574 - 7,387,253 (+)Ensemblrn6Rnor6.0
Rnor_5.047,366,726 - 7,398,606 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.446,192,644 - 6,224,285 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera46,444,570 - 6,473,521 (+)NCBICelera
RGSC_v3.146,192,643 - 6,224,284 (+)NCBI
Cytogenetic Map4q11NCBI
KCNH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387150,944,961 - 150,978,321 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7150,944,064 - 150,978,394 (-)Ensemblhg38GRCh38
GRCh377150,642,049 - 150,675,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,272,982 - 150,305,947 (-)NCBIBuild 36Build 36hg18NCBI36
Build 347150,079,696 - 150,090,563NCBI
Celera7145,199,077 - 145,232,050 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,454,320 - 144,487,268 (-)NCBIHuRef
CHM1_17150,650,401 - 150,683,838 (-)NCBICHM1_1
T2T-CHM13v2.07152,117,824 - 152,151,201 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27149,971,333 - 150,004,698 (-)NCBI
Kcnh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39524,524,583 - 24,556,671 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl524,524,587 - 24,556,602 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38524,319,589 - 24,351,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,319,589 - 24,351,604 (-)Ensemblmm10GRCm38
MGSCv37523,825,407 - 23,857,422 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36523,829,654 - 23,861,669 (-)NCBIMGSCv36mm8
Celera521,266,318 - 21,295,272 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map510.94NCBI
Kcnh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,391,384 - 5,422,241 (-)Ensembl
ChiLan1.0NW_0049554915,391,444 - 5,422,241 (-)NCBIChiLan1.0ChiLan1.0
KCNH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,362,612 - 187,395,976 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,372,876 - 39,406,239 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,528,979 - 142,562,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,680,927 - 154,713,525 (-)NCBIPanPan1.1PanPan1.1panPan2
KCNH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,009,031 - 15,041,786 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,009,031 - 15,041,504 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1615,617,297 - 15,650,061 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01616,724,206 - 16,757,289 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1616,724,490 - 16,757,289 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11615,103,715 - 15,136,482 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,685,081 - 15,717,872 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,735,820 - 15,768,605 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,491,041 - 6,523,203 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,379,669 - 6,412,390 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,380,222 - 6,412,390 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,243,524 - 6,279,111 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1186,242,826 - 6,279,154 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,719,117 - 6,725,624 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,123,601 - 119,156,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,124,007 - 119,156,794 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607215,095,069 - 15,128,476 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,632,726 - 5,663,771 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248005,633,060 - 5,663,700 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcnh2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16153,512,317 - 153,544,419 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcnh2
54 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:308
Count of miRNA genes:165
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000013800
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4128392287Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4128392287Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4128392287Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4842855130449094Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41075870140490708Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 159 86 85 54 89 54 6 343 189 10 134 76 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013800   ⟹   ENSRNOP00000013800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,719,583 - 11,751,421 (+)Ensembl
mRatBN7.2 Ensembl410,826,928 - 10,859,008 (+)Ensembl
Rnor_6.0 Ensembl47,355,574 - 7,387,253 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084826   ⟹   ENSRNOP00000073593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,741,407 - 11,751,421 (+)Ensembl
mRatBN7.2 Ensembl410,849,037 - 10,859,008 (+)Ensembl
Rnor_6.0 Ensembl47,377,563 - 7,387,240 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000152882   ⟹   ENSRNOP00000108708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,708,257 - 11,751,421 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000156111   ⟹   ENSRNOP00000107000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,692,980 - 11,751,421 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000171126   ⟹   ENSRNOP00000104113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl411,719,063 - 11,751,421 (+)Ensembl
RefSeq Acc Id: NM_053949   ⟹   NP_446401
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,719,782 - 11,751,422 (+)NCBI
mRatBN7.2410,827,369 - 10,859,009 (+)NCBI
Rnor_6.047,355,601 - 7,387,241 (+)NCBI
Rnor_5.047,366,726 - 7,398,606 (+)NCBI
RGSC_v3.446,192,644 - 6,224,285 (+)RGD
Celera46,444,570 - 6,473,521 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235867   ⟹   XP_006235929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,719,362 - 11,751,424 (+)NCBI
mRatBN7.2410,826,834 - 10,859,008 (+)NCBI
Rnor_6.047,355,066 - 7,387,282 (+)NCBI
Rnor_5.047,366,726 - 7,398,606 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762630   ⟹   XP_008760852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,741,410 - 11,751,424 (+)NCBI
mRatBN7.2410,848,982 - 10,859,008 (+)NCBI
Rnor_6.047,377,219 - 7,387,282 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039106950   ⟹   XP_038962878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,736,628 - 11,751,424 (+)NCBI
mRatBN7.2410,845,184 - 10,859,008 (+)NCBI
RefSeq Acc Id: XM_039106951   ⟹   XP_038962879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,719,357 - 11,746,027 (+)NCBI
mRatBN7.2410,826,834 - 10,853,613 (+)NCBI
RefSeq Acc Id: NP_446401   ⟸   NM_053949
- UniProtKB: O08720 (UniProtKB/Swiss-Prot),   O08962 (UniProtKB/Swiss-Prot),   F1LN86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235929   ⟸   XM_006235867
- Peptide Label: isoform X1
- UniProtKB: F1LN86 (UniProtKB/TrEMBL),   A6K569 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760852   ⟸   XM_008762630
- Peptide Label: isoform X3
- UniProtKB: Q6DKY7 (UniProtKB/TrEMBL),   A6K570 (UniProtKB/TrEMBL),   A0A0G2K5X4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073593   ⟸   ENSRNOT00000084826
Ensembl Acc Id: ENSRNOP00000013800   ⟸   ENSRNOT00000013800
RefSeq Acc Id: XP_038962879   ⟸   XM_039106951
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038962878   ⟸   XM_039106950
- Peptide Label: isoform X2
- UniProtKB: F1LN86 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108708   ⟸   ENSRNOT00000152882
Ensembl Acc Id: ENSRNOP00000107000   ⟸   ENSRNOT00000156111
Ensembl Acc Id: ENSRNOP00000104113   ⟸   ENSRNOT00000171126
Protein Domains
Cyclic nucleotide-binding   PAC   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08962-F1-model_v2 AlphaFold O08962 1-1163 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621414 AgrOrtholog
BioCyc Gene G2FUF-46033 BioCyc
Ensembl Genes ENSRNOG00000009872 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000013800 ENTREZGENE
  ENSRNOT00000084826 ENTREZGENE
  ENSRNOT00000171126 ENTREZGENE
Gene3D-CATH 1.10.1200.260 UniProtKB/Swiss-Prot
  1.10.287.70 UniProtKB/Swiss-Prot
  2.60.120.10 UniProtKB/Swiss-Prot
  PAS domain UniProtKB/Swiss-Prot
InterPro cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot
  K_chnl_volt-dep_ERG UniProtKB/Swiss-Prot
  KCNH_channel UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS-assoc_C UniProtKB/Swiss-Prot
  PAS-like_dom_sf UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
KEGG Report rno:117018 UniProtKB/Swiss-Prot
NCBI Gene 117018 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2 UniProtKB/Swiss-Prot
  VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL UniProtKB/Swiss-Prot
Pfam cNMP_binding UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
  PAS_9 UniProtKB/Swiss-Prot
PharmGKB KCNH2 RGD
PhenoGen Kcnh2 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot
  ERGCHANNEL UniProtKB/Swiss-Prot
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009872 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot
  SSF55785 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A0G2K5X4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LHI8_RAT UniProtKB/TrEMBL
  A0ABK0LRW9_RAT UniProtKB/TrEMBL
  A0ABK0LX62_RAT UniProtKB/TrEMBL
  A6K569 ENTREZGENE, UniProtKB/TrEMBL
  A6K570 ENTREZGENE, UniProtKB/TrEMBL
  F1LN86 ENTREZGENE, UniProtKB/TrEMBL
  KCNH2_RAT UniProtKB/Swiss-Prot
  O08720 ENTREZGENE
  O08962 ENTREZGENE
  Q6DKY7 ENTREZGENE
UniProt Secondary O08720 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnh2  potassium voltage-gated channel subfamily H member 2  Kcnh2  potassium channel, voltage gated eag related subfamily H, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnh2  potassium channel, voltage gated eag related subfamily H, member 2  Kcnh2  potassium voltage-gated channel, subfamily H (eag-related), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kcnh2  potassium voltage-gated channel, subfamily H (eag-related), member 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kcnh2  potassium voltage-gated channel, subfamily H (eag-related), member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in stomach fundus and antrum, brain, adrenal gland, thymus, retina, and skeletal muscle 625508
gene_function creates a voltage-dependent inward-rectifying K current 729087
gene_homology has 96% amino acid identify to HERG 729087
gene_process currents generated may counteract in the increase of muscle tone resulting in the regulation of the rhythms in stomach smooth muscle contraction 625508
gene_process responsible for the potassium current deactivation by depolarization 625508
gene_product 165-205 kDa protein 625508