GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Kcnh2 | affects binding | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | Terfenadine binds to KCNH2 protein | PMID:18701618 PMID:19260734 | Kcnh2 | decreases activity | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | Terfenadine results in decreased activity of KCNH2 protein | PMID:10422790 PMID:10604956 PMID:10828461 PMID:12070109 PMID:14709917 PMID:15671647 PMID:15740727 PMID:16278312 PMID:16931984 PMID:17042915 PMID:17513944 PMID:19915712 PMID:24052561 PMID:27553911 PMID:30561737 PMID:8641472 PMID:8772706 PMID:9395068 | Kcnh2 | multiple interactions | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | 2-(4-(2-(3,4-dichlorophenyl)ethyl)phenylamino)benzoic acid inhibits the reaction [Terfenadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]]; [Terfenadine co-treated with dofetilide] binds to and results in decreased activity of KCNH2 protein; [Terfenadine co-treated with ergotoxin, Centruroides noxius] binds to and results in decreased activity of KCNH2 protein; [Terfenadine co-treated with Fluvoxamine] binds to and results in decreased activity of KCNH2 protein; beta-Cyclodextrins analog inhibits the reaction [Terfenadine results in decreased activity of KCNH2 protein]; Chlorobutanol promotes the reaction [Terfenadine binds to and results in decreased activity of KCNH2 protein]; ciclopirox inhibits the reaction [Terfenadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]]; Hydrogen Peroxide inhibits the reaction [Terfenadine results in decreased activity of KCNH2 protein mutant form]; Terfenadine binds to and results in decreased activity of KCNH2 protein; Terfenadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Terfenadine promotes the reaction [Chlorobutanol binds to and results in decreased activity of KCNH2 protein]; Terfenadine promotes the reaction [Ketoconazole results in decreased activity of KCNH2 protein] | PMID:10828461 PMID:11005845 PMID:11705456 PMID:12388285 PMID:15272206 PMID:17513944 PMID:19583963 PMID:20071423 PMID:21158687 PMID:9658196 PMID:9694927 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |