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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:28593
Term: quinidine
Definition: A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.
Chemical ID: MESH:D011802
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2affects activityISOKCNH2 (Homo sapiens)6480464CTDQuinidine affects the activity of KCNH2 proteinPMID:22020101
Kcnh2affects bindingISOKCNH2 (Homo sapiens)6480464CTDQuinidine binds to KCNH2 proteinPMID:18701618
Kcnh2affects localizationISOKCNH2 (Homo sapiens)6480464CTDQuinidine affects the localization of KCNH2 protein mutant formPMID:11741928
Kcnh2affects response to substanceISOKCNH2 (Homo sapiens)6480464CTDKCNH2 gene SNP affects the susceptibility to QuinidinePMID:12695533
Kcnh2decreases activityISOKCNH2 (Homo sapiens)6480464CTDQuinidine results in decreased activity of KCNH2 proteinPMID:11741928 PMID:12695533 PMID:15671647 PMID:15673388 PMID:15821840 PMID:16960444 PMID:17042915 PMID:18057881 PMID:18724381 PMID:21362439 PMID:24052561 PMID:28551711
Kcnh2decreases response to substanceISOKCNH2 (Homo sapiens)6480464CTDKCNH2 gene mutant form results in decreased susceptibility to QuinidinePMID:15673388
Kcnh2multiple interactionsISOKCNH2 (Homo sapiens)6480464CTD[Quinidine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; Acids inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; Quinidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein]PMID:15821840 PMID:16960444 PMID:18057881 PMID:19583963 PMID:21158687 PMID:21362439
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