GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Kcnh2 | multiple interactions | EXP | | 6480464 | CTD | E 4031 inhibits the reaction [Progesterone results in decreased localization of KCNH2 protein] | PMID:21525004 | Kcnh2 | affects binding | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | E 4031 binds to KCNH2 protein | PMID:19260734 | Kcnh2 | affects localization | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | E 4031 affects the localization of KCNH2 protein mutant form | PMID:11741928 | Kcnh2 | decreases activity | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | E 4031 results in decreased activity of KCNH2 protein | PMID:11741928 PMID:12359267 PMID:14709917 PMID:16494862 PMID:16757186 PMID:17513944 PMID:18724381 PMID:20050851 PMID:23707769 PMID:24052561 | Kcnh2 | increases activity | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | E 4031 results in increased activity of KCNH2 protein mutant form | PMID:10531299 | Kcnh2 | multiple interactions | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | [KCNE2 protein binds to KCNH2 protein] which results in increased susceptibility to E 4031; beta-Cyclodextrins analog inhibits the reaction [E 4031 results in decreased activity of KCNH2 protein]; E 4031 binds to and results in decreased activity of KCNH2 protein; E 4031 inhibits the reaction [fexofenadine results in increased activity of KCNH2 protein mutant form]; E 4031 inhibits the reaction [Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]]; E 4031 inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; E 4031 inhibits the reaction [Niflumic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]]; E 4031 results in decreased activity of [KCNE2 protein binds to KCNH2 protein]; E 4031 results in increased glycosylation of and affects the localization of KCNH2 protein mutant form | PMID:10219239 PMID:10531299 PMID:12070109 PMID:12359267 PMID:15272206 PMID:17513944 PMID:19583963 PMID:21158687 | |
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