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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414 Species: Rattus norvegicus RGD Object: Gene Symbol: Kcnh2 Name: potassium voltage-gated channel, subfamily H (eag-related), member 2

Acc ID: CHEBI:16240 Term: hydrogen peroxide Definition: An inorganic peroxide that has formula H2O2. CasRN: 7722-84-1 Chemical ID: MESH:D006861

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:732101	6480464	CTD	Hydrogen Peroxide inhibits the reaction [Astemizole results in decreased activity of KCNH2 protein mutant form] Hydrogen Peroxide inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein mutant form] Hydrogen Peroxide inhibits the reaction [Terfenadine results in decreased activity of KCNH2 protein mutant form]	PMID:10828461