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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2decreases expressionEXP 6480464CTDValproic Acid results in decreased expression of KCNH2 mRNAPMID:33150595
Kcnh2increases methylationEXP 6480464CTDValproic Acid results in increased methylation of KCNH2 promoterPMID:33150595
Kcnh2affects expressionISOKCNH2 (Homo sapiens)6480464CTDValproic Acid affects the expression of KCNH2 mRNAPMID:25979313
Kcnh2increases expressionISOKCNH2 (Homo sapiens)6480464CTDValproic Acid results in increased expression of KCNH2 mRNAPMID:23179753 PMID:29154799
Kcnh2increases methylationISOKCNH2 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of KCNH2 genePMID:29154799
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