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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:34545
Term: Azimilide
Definition: An imidazolidine-2,4-dione that has formula C23H28ClN5O3.
Chemical ID: MESH:C086123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2decreases activityISOKCNH2 (Homo sapiens)6480464CTDazimilide results in decreased activity of KCNH2 proteinPMID:15821840 PMID:16960444 PMID:18057881
Kcnh2multiple interactionsISOKCNH2 (Homo sapiens)6480464CTDAcids inhibits the reaction [azimilide results in decreased activity of KCNH2 protein]; azimilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [azimilide results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [azimilide results in decreased activity of KCNH2 protein]PMID:15821840 PMID:16960444 PMID:18057881
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