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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:5292
Term: geldanamycin
Definition: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.
Chemical ID: MESH:C001277
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2affects localizationISOKCNH2 (Homo sapiens)6480464CTDgeldanamycin affects the localization of KCNH2 proteinPMID:12775586
Kcnh2decreases activityISOKCNH2 (Homo sapiens)6480464CTDgeldanamycin results in decreased activity of KCNH2 proteinPMID:12775586 PMID:24052561
Kcnh2decreases expressionISOKCNH2 (Homo sapiens)6480464CTDgeldanamycin results in decreased expression of KCNH2 protein modified formPMID:12775586
Kcnh2increases degradationISOKCNH2 (Homo sapiens)6480464CTDgeldanamycin results in increased degradation of KCNH2 proteinPMID:12775586
Kcnh2multiple interactionsISOKCNH2 (Homo sapiens)6480464CTDgeldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]PMID:12775586
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