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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:5118
Term: fluoxetine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Chemical ID: MESH:D005473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2affects localizationISOKCNH2 (Homo sapiens)6480464CTDFluoxetine affects the localization of KCNH2 proteinPMID:16967046
Kcnh2affects response to substanceISOKCNH2 (Homo sapiens)6480464CTDKCNH2 protein affects the susceptibility to FluoxetinePMID:16967046
Kcnh2decreases activityISOKCNH2 (Homo sapiens)6480464CTDFluoxetine results in decreased activity of KCNH2 proteinPMID:16967046 PMID:24052561
Kcnh2decreases expressionISOKCNH2 (Homo sapiens)6480464CTDFluoxetine results in decreased expression of KCNH2 protein modified formPMID:35680041
Kcnh2multiple interactionsISOKCNH2 (Homo sapiens)6480464CTDFluoxetine binds to and results in decreased activity of KCNH2 protein; Fluoxetine inhibits the reaction [KCNH2 protein results in increased transport of Potassium]; Fluoxetine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]PMID:11805215 PMID:15272206 PMID:21158687
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