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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:15854
Term: quinine
Definition: A cinchona alkaloid that is cinchonidine in which the hydrogen at the 6-position of the quinoline ring is substituted by methoxy.
Chemical ID: MESH:D011803
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2affects response to substanceISOKCNH2 (Homo sapiens)6480464CTDKCNH2 gene SNP affects the susceptibility to QuininePMID:12695533
Kcnh2decreases activityISOKCNH2 (Homo sapiens)6480464CTDQuinine results in decreased activity of KCNH2 proteinPMID:12695533 PMID:28551711
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