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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:3720
Term: cisapride
Definition: The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere.
Chemical ID: MESH:D020117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2affects bindingISOKCNH2 (Homo sapiens)6480464CTDCisapride binds to KCNH2 proteinPMID:18701618 PMID:19260734
Kcnh2affects localizationISOKCNH2 (Homo sapiens)6480464CTDCisapride affects the localization of KCNH2 protein mutant formPMID:10531299 PMID:11741928
Kcnh2decreases activityISOKCNH2 (Homo sapiens)6480464CTDCisapride results in decreased activity of KCNH2 proteinPMID:11741928 PMID:15306208 PMID:15671647 PMID:15740727 PMID:17513944 PMID:24052561 PMID:24830940 PMID:27553911 PMID:28551711 PMID:30561737 PMID:9395068
Kcnh2multiple interactionsISOKCNH2 (Homo sapiens)6480464CTDbeta-Cyclodextrins analog inhibits the reaction [Cisapride results in decreased activity of KCNH2 protein]; Cisapride binds to and results in decreased activity of KCNH2 protein; Cisapride inhibits the reaction [KCNH2 protein results in increased transport of Thallium]PMID:11005845 PMID:12388285 PMID:15272206 PMID:17513944 PMID:19583963 PMID:21158687
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