RGD Reference Report - Expression of the IKr components KCNH2 (rERG) and KCNE2 (rMiRP1) during late rat heart development. - Rat Genome Database

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Expression of the IKr components KCNH2 (rERG) and KCNE2 (rMiRP1) during late rat heart development.

Authors: Chun, KR  Koenen, M  Katus, HA  Zehelein, J 
Citation: Chun KR, etal., Exp Mol Med. 2004 Aug 31;36(4):367-71.
RGD ID: 7243961
Pubmed: PMID:15365256   (View Abstract at PubMed)
DOI: DOI:10.1038/emm.2004.48   (Journal Full-text)

To understand molecular mechanisms that regulate formation and maintenance of cardiac IKr (rapidly activating component of the delayed rectifier K+ current), we have investigated the spatiotemporal expression pattern of two rat potassium voltage-gated channels, namely subfamily H (eag-related), member2 (KCNH2) (alias name: rERG) and Isk-related family, member2 (KCNE2) (alias name: rMiRP1) during late embryonic development by means of the in situ hybridization technique. KCNE2 is transcribed predominantly in atrial und ventricular myocardium at stages E14.5-E18.5dpc and only a minor signal emerged in the tongue at E16.5dpc. In contrast, KCNH2 transcripts appeared in a less confined pattern with intense signals in atrial and ventricular myocardium, somites, spinal cord, bowel system, central nervous system and thymus at stages E14.5-E18.5dpc. Non-cardiac expression even exceeds the intensity of the cardiac signal, indicating that KCNH2 contributes to K+ currents in non-cardiac tissue as well. Transcription of the rat b-subunit KCNE2 is present in all regions of the fetal myocardium and co-distributes perfectly with transcription of the pore forming a-subunit KCNH2. It seems likely that KCNH2 and KCNE2 are linked to form cardiac IKr channels, associated to cardiogenesis and cardiomyocyte excitability.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
spinal cord development  IEP 7243961 RGD 
tongue development  IEP 7243961 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kcne2  (potassium voltage-gated channel subfamily E regulatory subunit 2)
Kcnh2  (potassium voltage-gated channel subfamily H member 2)

Objects referenced in this article
Gene Stat6 signal transducer and activator of transcription 6 Rattus norvegicus

Additional Information