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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2decreases activityEXP 6480464CTDSimvastatin results in decreased activity of KCNH2 proteinPMID:30086269
Kcnh2decreases localizationEXP 6480464CTDSimvastatin results in decreased localization of KCNH2 proteinPMID:21525004
Kcnh2multiple interactionsEXP 6480464CTDBerberine promotes the reaction [Simvastatin results in decreased activity of KCNH2 protein]PMID:30086269
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