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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:5051
Term: Fexofenadine hydrochloride
Definition: null
Chemical ID: MESH:C093230
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2increases activityISOKCNH2 (Homo sapiens)6480464CTDfexofenadine results in increased activity of KCNH2 protein mutant formPMID:12070109
Kcnh2multiple interactionsISOKCNH2 (Homo sapiens)6480464CTDE 4031 inhibits the reaction [fexofenadine results in increased activity of KCNH2 protein mutant form]; fexofenadine inhibits the reaction [arsenic trioxide results in increased degradation of KCNH2 protein]PMID:12070109 PMID:28521025
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