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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621414
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnh2decreases expressionISOKCNH2 (Homo sapiens)6480464CTDCisplatin results in decreased expression of KCNH2 mRNAPMID:27594783
Kcnh2increases expressionISOKCNH2 (Homo sapiens)6480464CTDCisplatin results in increased expression of KCNH2PMID:22020779
Kcnh2increases response to substanceISOKCNH2 (Homo sapiens)6480464CTDKCNH2 results in increased susceptibility to CisplatinPMID:22020779
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