Pten (phosphatase and tensin homolog) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Pten (phosphatase and tensin homolog) Rattus norvegicus
Analyze
Symbol: Pten
Name: phosphatase and tensin homolog
RGD ID: 61995
Description: Enables several functions, including PDZ domain binding activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to peptide hormone stimulus; negative regulation of developmental growth; and positive regulation of cytokine production. Located in dendritic spine and postsynaptic membrane. Is active in postsynaptic cytosol. Used to study portal hypertension and substance-related disorder. Biomarker of several diseases, including acute myocardial infarction; glucose metabolism disease (multiple); liver disease (multiple); retinal disease (multiple); and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 1; breast cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog); PARTICIPATES IN altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; endometrial cancer pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inositol polyphosphate 3-phosphatase; Mmac; MMAC1; mutated in multiple advanced cancers 1; phosphatase and tensin homolog (mutated in multiple advanced cancers 1); phosphatase and tensin homolog deleted on chromosome ten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase and tensin-like protein; TEP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Ptenem1Sage
Genetic Models: SD-Ptenem1Sage
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,043,707 - 240,110,330 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1240,043,707 - 240,110,330 (+)EnsemblGRCr8
mRatBN7.21230,630,443 - 230,697,070 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1230,630,338 - 230,696,838 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1239,010,509 - 239,075,549 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01245,940,213 - 246,005,253 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01238,778,317 - 238,843,363 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,421,814 - 251,487,634 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,421,596 - 251,487,832 (+)Ensemblrn6Rnor6.0
Rnor_5.01258,651,829 - 258,717,009 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41236,771,027 - 236,837,261 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1227,746,622 - 227,812,108 (+)NCBICelera
RGSC_v3.11236,935,049 - 237,001,284 (+)NCBI
Cytogenetic Map1q52NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISS)
acute megakaryocytic leukemia  (ISO)
acute myocardial infarction  (IEP,ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
angiomyolipoma  (ISO)
anisometropia  (ISO)
asthma  (ISO)
Ataxia  (ISO)
autism spectrum disorder  (ISO,ISS)
autistic disorder  (ISO)
bacterial pneumonia  (ISO)
biliary atresia  (ISO)
bladder squamous cell carcinoma  (ISO)
brain disease  (ISS)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (IEP,ISO)
Cardiovascular Abnormalities  (ISO)
cataract  (ISO)
cerebral cavernous malformation  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chlamydiaceae Infections  (ISO)
cholangiocarcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Congenital Hypomyelinating Neuropathy  (ISO)
Cowden syndrome  (ISO,ISS)
Cowden syndrome 1  (ISO,ISS)
Craniofacial Abnormalities  (ISO)
developmental coordination disorder  (ISO)
Developmental Disabilities  (ISO)
diabetes mellitus  (IEP)
Diabetic Nephropathies  (IEP)
diabetic retinopathy  (IEP)
diffuse large B-cell lymphoma  (ISO)
Disease Progression  (ISO)
Ductal Carcinoma  (ISO)
dysplastic nevus syndrome  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial cancer  (ISS)
endometrial carcinoma  (ISO)
endometrial hyperplasia  (ISO)
Endometrial Intraepithelial Neoplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
epilepsy  (ISO)
Epstein-Barr virus infectious disease  (ISO)
esophageal cancer  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Melanoma  (ISO)
familial melanoma  (ISO)
familial meningioma  (ISO)
Familial Prostate Cancer  (ISO)
fetal alcohol spectrum disorder  (IEP)
Follicular Thyroid Cancer  (ISO)
follicular thyroid carcinoma  (ISO,ISS)
gastric adenocarcinoma  (ISO)
Gastrointestinal Neoplasms  (ISO)
generalized epilepsy  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
Helicobacter Infections  (ISO)
hemangioma  (ISO)
hemangiopericytoma  (ISO)
Hemimegalencephaly  (ISO)
hepatitis B  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (IEP,ISO,ISS)
Hepatomegaly  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
hyperinsulinism  (IEP)
hypertension  (ISO)
Hypertrophy  (ISO)
in situ carcinoma  (ISO)
Insulin Resistance  (IDA,ISO)
intellectual disability  (ISO)
intermediate coronary syndrome  (ISO)
intestinal pseudo-obstruction  (ISS)
Intimal Hyperplasia  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
juvenile polyposis syndrome  (ISO)
Language Development Disorders  (ISO)
Left Ventricular Hypertrophy  (IDA,IEP)
leiomyoma  (ISO)
leukemia  (ISO)
lipoma  (ISO)
lipomatosis  (ISO)
liver cirrhosis  (ISO)
long QT syndrome  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphoma  (ISO)
Macrocephaly  (ISO)
macrocephaly-autism syndrome  (ISO,ISS)
major depressive disorder  (ISO)
melanoma  (ISO)
meningioma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Multiple Abnormalities  (ISO)
muscular dystrophy  (ISO)
myeloproliferative neoplasm  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
Nerve Sheath Neoplasms  (ISO)
Nervous System Malformations  (ISO)
Neurodevelopmental Disorders  (ISO)
Noonan syndrome with multiple lentigines  (ISO)
oral squamous cell carcinoma  (ISO)
osteochondrodysplasia  (ISO)
osteogenesis imperfecta type 1  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous carcinoma  (ISO)
pancreatic cancer  (ISO)
papillary tumor of the pineal region  (ISO)
papillomavirus infectious disease  (ISO)
peripheral nervous system neoplasm  (ISO)
persistent fetal circulation syndrome  (ISS)
Pneumococcal Pneumonia  (ISO)
polydactyly  (ISO)
portal hypertension  (IDA)
prostate cancer  (ISO,ISS)
Prostate Cancer, Hereditary, 1  (ISO)
Prostate Cancer, Somatic  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
Proteus syndrome  (ISO)
Pseudomonas Infections  (ISO)
PTEN hamartoma tumor syndrome  (ISO)
renal cell carcinoma  (IEP,ISO)
Reperfusion Injury  (IMP,ISO)
retinitis pigmentosa  (IEP)
rhabdomyosarcoma  (ISO)
schizophrenia  (ISO)
Septic Peritonitis  (ISO)
Sezary's disease  (ISO)
silicosis  (ISO)
skin disease  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
skin squamous cell carcinoma  (ISO)
Spinal Cord Injuries  (IEP)
sporadic breast cancer  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (IEP,ISO,ISS)
stomach cancer  (ISO)
stomach disease  (IEP)
substance-related disorder  (IMP)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (IEP)
urinary bladder cancer  (ISO,ISS)
Uterine Cervical Neoplasms  (ISO)
uterine corpus cancer  (ISO)
X-linked VACTERL association  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-noradrenaline  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
10-DEBC hydrochloride  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxypsoralen  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
ammonium chloride  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
astaxanthin  (ISO)
atorvastatin calcium  (EXP)
benomyl  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
berberine  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
biliverdin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
celastrol  (EXP)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciglitazone  (EXP)
ciguatoxin CTX1B  (ISO)
cilostazol  (EXP,ISO)
cisplatin  (ISO)
cladribine  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin E  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cytarabine  (ISO)
D-glucitol  (EXP,ISO)
D-glucose  (ISO)
dactolisib  (ISO)
dapagliflozin  (EXP)
daunorubicin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
EHT 1864  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
fenhexamid  (ISO)
ferulic acid  (EXP)
flavanone  (ISO)
fludioxonil  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
gallic acid  (ISO)
gefitinib  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
geraniol  (EXP)
ginsenoside Rg1  (ISO)
glucose  (ISO)
glufosinate  (ISO)
gossypetin  (ISO)
graphene oxide  (ISO)
hemin  (ISO)
hesperetin  (EXP)
hexadecanoic acid  (EXP)
hydrogen peroxide  (ISO)
hydroxyflutamide  (EXP)
iberiotoxin  (ISO)
indometacin  (ISO)
isoprenaline  (EXP,ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lactucin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
linsidomine  (EXP)
lipopolysaccharide  (EXP,ISO)
lovastatin  (EXP,ISO)
lupeol  (EXP,ISO)
luteolin  (EXP)
LY294002  (EXP,ISO)
maculosin  (ISO)
malonaldehyde  (ISO)
mercury dichloride  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (EXP,ISO)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (EXP,ISO)
methylseleninic acid  (ISO)
mevinphos  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
orlistat  (ISO)
osthole  (ISO)
oxybenzone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
paxilline  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
peroxynitrous acid  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phosphatidylcholine  (ISO)
phosphatidylethanolamine  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
plumbagin  (EXP)
potassium iodide  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
propofol  (ISO)
prostaglandin E2  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rimonabant  (EXP)
rivastigmine  (EXP)
rotenone  (ISO)
rutin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thalidomide  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
trovafloxacin  (ISO)
tubastatin A  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
veliparib  (ISO)
Vernodalol  (ISO)
vinclozolin  (EXP)
vinyl carbamate  (ISO)
vorinostat  (ISO)
WIN 55212-2  (EXP)
wortmannin  (EXP,ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (ISO)
angiogenesis  (ISO)
apoptotic process  (IEA,ISO)
brain morphogenesis  (ISO)
cardiac muscle tissue development  (ISO)
cell migration  (ISO)
cell motility  (IBA)
cellular response to decreased oxygen levels  (ISO)
cellular response to electrical stimulus  (ISO)
cellular response to ethanol  (IDA)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (IDA)
cellular response to insulin-like growth factor stimulus  (IDA)
cellular response to leptin stimulus  (IMP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to sorbitol  (IEP)
central nervous system development  (ISO)
central nervous system myelin maintenance  (ISO)
central nervous system neuron axonogenesis  (ISO)
dendritic spine morphogenesis  (ISO)
dentate gyrus development  (ISO)
endothelial cell migration  (ISO)
forebrain morphogenesis  (ISO)
gene expression  (ISO)
heart development  (ISO)
inositol phosphate catabolic process  (IDA)
learning or memory  (ISO)
lipid metabolic process  (IEA)
locomotor rhythm  (ISO)
locomotory behavior  (ISO)
long-term synaptic depression  (IMP)
long-term synaptic potentiation  (ISO)
male mating behavior  (ISO)
maternal behavior  (ISO)
memory  (IMP)
multicellular organismal response to stress  (ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of axon regeneration  (ISO)
negative regulation of axonogenesis  (ISO)
negative regulation of cardiac muscle cell proliferation  (IEA,IMP,ISO)
negative regulation of cell communication  (IEA)
negative regulation of cell cycle  (IMP)
negative regulation of cell cycle G1/S phase transition  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (IDA,IEA,ISO)
negative regulation of cell size  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of defense response to bacterium  (IMP)
negative regulation of dendrite extension  (IMP)
negative regulation of dendritic spine morphogenesis  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of excitatory postsynaptic potential  (ISO)
negative regulation of focal adhesion assembly  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of keratinocyte migration  (ISO)
negative regulation of myelination  (ISO)
negative regulation of neuron projection development  (IDA,IEA)
negative regulation of organ growth  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of phagocytosis  (IMP)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of potassium ion transmembrane transporter activity  (IMP)
negative regulation of protein kinase activity by regulation of protein phosphorylation  (ISO)
negative regulation of ribosome biogenesis  (ISO)
negative regulation of signaling  (IEA)
negative regulation of signaling receptor activity  (IMP)
negative regulation of synaptic vesicle clustering  (ISO)
negative regulation of TORC1 signaling  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of wound healing, spreading of epidermal cells  (ISO)
nervous system development  (IEA)
neuron projection development  (IDA)
neuron-neuron synaptic transmission  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA)
phosphatidylinositol dephosphorylation  (IBA,IDA,IEA,IMP,ISO)
platelet-derived growth factor receptor signaling pathway  (IDA)
positive regulation of apoptotic process  (IMP)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of interleukin-6 production  (IMP)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of macromolecule metabolic process  (IEA)
positive regulation of neuron differentiation  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO)
postsynaptic density assembly  (ISO)
prepulse inhibition  (ISO)
presynaptic membrane assembly  (ISO)
prostate gland growth  (ISO)
protein dephosphorylation  (IMP,ISO)
protein stabilization  (ISO)
regulation of axon regeneration  (ISO)
regulation of B cell apoptotic process  (ISO)
regulation of cell cycle  (IEA,ISO)
regulation of cell differentiation  (IEA)
regulation of cellular component size  (ISO)
regulation of cellular localization  (ISO)
regulation of Fc receptor mediated stimulatory signaling pathway  (IMP)
regulation of myeloid cell apoptotic process  (ISO)
regulation of neuron projection development  (ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA)
regulation of protein stability  (ISO)
regulation of signal transduction  (IEA)
regulation of synaptic transmission, GABAergic  (ISO)
response to activity  (IEP)
response to arsenic-containing substance  (IEP)
response to ATP  (IEP)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to glucose  (IEP)
response to nutrient  (IEP)
response to quercetin  (IEP)
response to xenobiotic stimulus  (IEP)
response to zinc ion  (IEP)
rhythmic synaptic transmission  (ISO)
social behavior  (ISO)
spindle assembly involved in female meiosis  (ISO)
synapse assembly  (ISO)
synapse maturation  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms. Alexander MS, etal., J Clin Invest. 2014 Jun;124(6):2651-67. doi: 10.1172/JCI73579. Epub 2014 May 1.
2. Combination of PTEN gene therapy and radiation inhibits the growth of human prostate cancer xenografts. Anai S, etal., Hum Gene Ther. 2006 Oct;17(10):975-84.
3. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Anzelon AN, etal., Nat Immunol 2003 Mar;4(3):287-94.
4. Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Backman SA, etal., Nat Genet 2001 Dec;29(4):396-403.
5. Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten. Backman SA, etal., Proc Natl Acad Sci U S A 2004 Feb 10;101(6):1725-30. Epub 2004 Jan 27.
6. Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors. Bakirtzi K, etal., Gastroenterology. 2011 Nov;141(5):1749-61.e1. doi: 10.1053/j.gastro.2011.07.038. Epub 2011 Jul 30.
7. Intact PTEN Expression by Immunohistochemistry is Associated With Decreased Survival in Advanced Stage Ovarian/Primary Peritoneal High-grade Serous Carcinoma. Bakkar RM, etal., Int J Gynecol Pathol. 2015 Nov;34(6):497-506. doi: 10.1097/PGP.0000000000000205.
8. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Bansal N, etal., Cancer Control. 2009 Jan;16(1):8-13.
9. The mutational landscape of prostate cancer. Barbieri CE, etal., Eur Urol. 2013 Oct;64(4):567-76. doi: 10.1016/j.eururo.2013.05.029. Epub 2013 May 18.
10. Reduced expression of PTEN correlates with breast cancer progression. Bose S, etal., Hum Pathol. 2002 Apr;33(4):405-9.
11. Novel PTEN germline mutation in a family with mild phenotype: difficulties in genetic counseling. Busa T, etal., Gene. 2013 Jan 10;512(2):194-7. doi: 10.1016/j.gene.2012.09.134. Epub 2012 Nov 2.
12. Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. Butler MG, etal., J Med Genet. 2005 Apr;42(4):318-21.
13. Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. Cairns P, etal., Oncogene. 1998 Jun 18;16(24):3215-8.
14. Activation of phosphatase and tensin homolog on chromosome 10 mediates the inhibition of FcgammaR phagocytosis by prostaglandin E2 in alveolar macrophages. Canetti C, etal., J Immunol. 2007 Dec 15;179(12):8350-6.
15. Peripubertal hyperinsulinemia upregulates phosphatidylinositol 3-kinase/akt pathway in rat ovaries. Chakrabarty S and Nagamani M, Reprod Sci. 2008 Apr;15(3):274-84.
16. Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma. Chen MH, etal., Oncotarget. 2014 May 15;5(9):2372-89. doi: 10.18632/oncotarget.1706.
17. PTEN inactivation by germline/somatic c.950_953delTACT mutation in patients with Lhermitte-Duclos disease manifesting progressive phenotypes. Chen XY, etal., Clin Genet. 2014 Oct;86(4):349-54. doi: 10.1111/cge.12282. Epub 2013 Oct 25.
18. 17 Beta-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats. Choi YC, etal., Fundam Clin Pharmacol. 2004 Oct;18(5):547-57.
19. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Crackower MA, etal., Cell 2002 Sep 20;110(6):737-49.
20. ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. Cruz CM, etal., J Biol Chem. 2007 Feb 2;282(5):2871-9. Epub 2006 Nov 27.
21. Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/beta-TrCP. Cuadrado A Free Radic Biol Med. 2015 Nov;88(Pt B):147-57. doi: 10.1016/j.freeradbiomed.2015.04.029. Epub 2015 Apr 30.
22. Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver. Cui X, etal., Toxicol Pathol. 2004 Jan-Feb;32(1):64-72.
23. Significance of P16INK4A Expression and PTEN Loss of Heterozygosity in Human Papilloma Virus-related Oral Squamous Cell Carcinoma. DE Jesus Oliveira Kato V, etal., Anticancer Res. 2020 Nov;40(11):6355-6366. doi: 10.21873/anticanres.14656.
24. Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase/Akt neuroprotective signaling pathway. Delgado-Esteban M, etal., J Neurochem. 2007 Jul;102(1):194-205. Epub 2007 Feb 14.
25. Pten is essential for embryonic development and tumour suppression. Di Cristofano A, etal., Nat Genet 1998 Aug;19(4):348-55.
26. Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse. Di Cristofano A, etal., Nat Genet 2001 Feb;27(2):222-4.
27. Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis. Dihal AA, etal., Proteomics. 2008 Jan;8(1):45-61.
28. Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis. Dourdin N, etal., Cancer Res. 2008 Apr 1;68(7):2122-31.
29. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Engelman JA, etal., Nat Rev Genet. 2006 Aug;7(8):606-19.
30. Par-3-mediated junctional localization of the lipid phosphatase PTEN is required for cell polarity establishment. Feng W, etal., J Biol Chem. 2008 Aug 22;283(34):23440-9. doi: 10.1074/jbc.M802482200. Epub 2008 Jun 10.
31. PI3K/Akt: getting it right matters. Franke TF Oncogene. 2008 Oct 27;27(50):6473-88.
32. Silencing of the PTEN tumor-suppressor gene in anaplastic thyroid cancer. Frisk T, etal., Genes Chromosomes Cancer. 2002 Sep;35(1):74-80.
33. Promoter methylation of the PTEN gene is a common molecular change in breast cancer. García JM, etal., Genes Chromosomes Cancer. 2004 Oct;41(2):117-24.
34. Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN. Garl PJ, etal., Circ Res 2004 Feb 6;94(2):175-83. Epub 2003 Dec 1.
35. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
36. Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs. Gil A, etal., Mol Biol Cell. 2006 Sep;17(9):4002-13. Epub 2006 Jun 28.
37. Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. Gimm O, etal., Am J Pathol. 2000 May;156(5):1693-700.
38. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Groszer M, etal., Science 2001 Dec 7;294(5549):2186-9. Epub 2001 Nov 01.
39. Regulation of PI 3-K, PTEN, p53, and mTOR in Malignant and Benign Tumors Deficient in Tuberin. Habib SL, etal., Genes Cancer. 2011 Nov;2(11):1051-60. doi: 10.1177/1947601912445376.
40. PTEN expression in renal cell carcinoma and oncocytoma and prognosis. Hager M, etal., Pathology. 2007 Oct;39(5):482-5.
41. Co-existence of high levels of the PTEN protein with enhanced Akt activation in renal cell carcinoma. He L, etal., Biochim Biophys Acta. 2007 Oct;1772(10):1134-42. Epub 2007 Jul 12.
42. A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer. Hellwinkel OJ, etal., BJU Int. 2008 Jun;101(11):1454-60. Epub 2008 Mar 11.
43. Pten loss induces autocrine FGF signaling to promote skin tumorigenesis. Hertzler-Schaefer K, etal., Cell Rep. 2014 Mar 13;6(5):818-26. doi: 10.1016/j.celrep.2014.01.045. Epub 2014 Feb 27.
44. Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma. Hino R, etal., Cancer Res. 2009 Apr 1;69(7):2766-74. doi: 10.1158/0008-5472.CAN-08-3070.
45. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
46. Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. Hodakoski C, etal., Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):155-60. doi: 10.1073/pnas.1213773111. Epub 2013 Dec 23.
47. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. Horie Y, etal., J Clin Invest 2004 Jun;113(12):1774-83.
48. PTEN and NDUFB8 aberrations in cervical cancer tissue. Hsieh SM, etal., Adv Exp Med Biol. 2007;599:31-6.
49. Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase. Hsiung SC, etal., J Neurochem. 2003 Oct;87(1):182-94. doi: 10.1046/j.1471-4159.2003.01987.x.
50. Knockdown of lncRNA MALAT1 attenuates acute myocardial infarction through miR-320-Pten axis. Hu H, etal., Biomed Pharmacother. 2018 Oct;106:738-746. doi: 10.1016/j.biopha.2018.06.122. Epub 2018 Jul 11.
51. Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinoma. Hu TH, etal., Cancer. 2003 Apr 15;97(8):1929-40. doi: 10.1002/cncr.11266.
52. Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia. Huang J, etal., Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):354-8. doi: 10.1161/01.ATV.0000151619.54108.a5. Epub 2004 Nov 29.
53. PTEN limits alveolar macrophage function against Pseudomonas aeruginosa after bone marrow transplantation. Hubbard LL, etal., Am J Respir Cell Mol Biol. 2011 Nov;45(5):1050-8. doi: 10.1165/rcmb.2011-0079OC. Epub 2011 Apr 28.
54. Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse. Ji SP, etal., Nat Med. 2006 Mar;12(3):324-9. Epub 2006 Feb 12.
55. PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. Jurado S, etal., EMBO J. 2010 Aug 18;29(16):2827-40. Epub 2010 Jul 13.
56. Androgen signaling and its interactions with other signaling pathways in prostate cancer. Kaarbo M, etal., Bioessays. 2007 Dec;29(12):1227-38.
57. Immunohistochemical expression of PTEN in normal, hyperplastic and malignant endometrium and its correlation with hormone receptors, bcl-2, bax, and apoptotic index. Kapucuoglu N, etal., Pathol Res Pract. 2007;203(3):153-62. Epub 2007 Feb 20.
58. Expression of proliferative and preapoptotic molecules in human myometrium and leiomyoma throughout the menstrual cycle. Kayisli UA, etal., Reprod Sci. 2007 Oct;14(7):678-86.
59. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
60. Akt and mTORC1 have different roles during liver tumorigenesis in mice. Kenerson HL, etal., Gastroenterology. 2013 May;144(5):1055-65. doi: 10.1053/j.gastro.2013.01.053. Epub 2013 Jan 30.
61. PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors. Keng VW, etal., Cancer Res. 2012 Jul 1;72(13):3405-13. doi: 10.1158/0008-5472.CAN-11-4092. Epub 2012 Jun 14.
62. Using tumor markers to predict the survival of patients with metastatic renal cell carcinoma. Kim HL, etal., J Urol. 2005 May;173(5):1496-501.
63. Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Kim MJ, etal., Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2884-9. Epub 2002 Feb 19.
64. MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2. Kim RY, etal., J Allergy Clin Immunol. 2017 Feb;139(2):519-532. doi: 10.1016/j.jaci.2016.04.038. Epub 2016 Jun 10.
65. PTEN recruitment controls synaptic and cognitive function in Alzheimer's models. Knafo S, etal., Nat Neurosci. 2016 Mar;19(3):443-53. doi: 10.1038/nn.4225. Epub 2016 Jan 18.
66. Phosphorylation of PTEN (phosphatase and tensin homologue deleted on chromosome ten) protein is enhanced in human fibromyomatous uteri. Kovacs KA, etal., J Steroid Biochem Mol Biol. 2007 Feb;103(2):196-9. Epub 2006 Nov 9.
67. Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN. Kreis P, etal., PLoS One. 2013 Aug 5;8(8):e71957. doi: 10.1371/journal.pone.0071957. Print 2013.
68. Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles. Kurose K, etal., Jpn J Cancer Res. 1998 Aug;89(8):842-8.
69. Regulation of PTEN expression in neuronal apoptosis. Kyrylenko S, etal., Brain Res Mol Brain Res 1999 Nov 10;73(1-2):198-202.
70. A role for nuclear PTEN in neuronal differentiation. Lachyankar MB, etal., J Neurosci. 2000 Feb 15;20(4):1404-13.
71. Oroxin B Induces Apoptosis by Down-Regulating MicroRNA-221 Resulting in the Inactivation of the PTEN/PI3K/AKT Pathway in Liver Cancer. Li N, etal., Molecules. 2019 Nov 30;24(23). pii: molecules24234384. doi: 10.3390/molecules24234384.
72. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Li Y, etal., Blood. 2011 Jun 16;117(24):6702-13. doi: 10.1182/blood-2010-09-309864. Epub 2011 Apr 26.
73. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Liaw D, etal., Nat Genet. 1997 May;16(1):64-7.
74. Tissue microarray based analysis of prognostic markers in invasive bladder cancer: much effort to no avail? Liedberg F, etal., Urol Oncol. 2008 Jan-Feb;26(1):17-24. Epub 2007 Oct 22.
75. Serum Exosomal MicroRNA-21, MicroRNA-126, and PTEN Are Novel Biomarkers for Diagnosis of Acute Coronary Syndrome. Ling H, etal., Front Physiol. 2020 Jun 11;11:654. doi: 10.3389/fphys.2020.00654. eCollection 2020.
76. Regulation of GABAA receptors by fragile X mental retardation protein. Liu B, etal., Int J Physiol Pathophysiol Pharmacol. 2013 Sep 10;5(3):169-76. eCollection 2013.
77. MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN. Liu ZL, etal., Mol Cell Biochem. 2013 Jan;372(1-2):35-45. doi: 10.1007/s11010-012-1443-3. Epub 2012 Sep 6.
78. Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K/Akt/VEGF signaling pathway in diabetic retinopathy. Lu JM, etal., Exp Eye Res. 2020 Jan;190:107886. doi: 10.1016/j.exer.2019.107886. Epub 2019 Nov 21.
79. Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis. Lynch ED, etal., Am J Hum Genet. 1997 Dec;61(6):1254-60.
80. Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway. Ma Z, etal., Eur J Appl Physiol. 2013 Oct;113(10):2473-86. doi: 10.1007/s00421-013-2685-9. Epub 2013 Jun 28.
81. Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase. Mahimainathan L and Choudhury GG, J Biol Chem 2004 Apr 9;279(15):15258-68. Epub 2004 Jan 12.
82. Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN. Mahimainathan L, etal., Diabetes. 2006 Jul;55(7):2115-25.
83. Alterations of mTOR and PTEN protein expression in schistosomal squamous cell carcinoma and urothelial carcinoma. Makboul R, etal., Pathol Res Pract. 2016 May;212(5):385-92. doi: 10.1016/j.prp.2016.02.008. Epub 2016 Feb 9.
84. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
85. PTEN positively regulates UVB-induced DNA damage repair. Ming M, etal., Cancer Res. 2011 Aug 1;71(15):5287-95. doi: 10.1158/0008-5472.CAN-10-4614. Epub 2011 Jul 19.
86. Inhibition of neuronal phenotype by PTEN in PC12 cells. Musatov S, etal., Proc Natl Acad Sci U S A 2004 Mar 9;101(10):3627-31. Epub 2004 Feb 27.
87. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
88. Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN. Ning K, etal., J Neurosci. 2004 Apr 21;24(16):4052-60.
89. Immunohistochemical expression of PTEN and beta-catenin for endometrial intraepithelial neoplasia in Japanese women. Norimatsu Y, etal., Ann Diagn Pathol. 2007 Apr;11(2):103-8.
90. Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. Okami K, etal., Cancer Res. 1998 Feb 1;58(3):509-11.
91. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
92. Enhanced phosphorylation of PTEN in rat brain after transient middle cerebral artery occlusion. Omori N, etal., Brain Res 2002 Nov 8;954(2):317-22.
93. Activation of PPAR-¿ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells. Paintlia AS, etal., Glia. 2010 Nov 1;58(14):1669-85. doi: 10.1002/glia.21039.
94. AMPK regulates K(ATP) channel trafficking via PTEN inhibition in leptin-treated pancreatic ß-cells. Park SH, etal., Biochem Biophys Res Commun. 2013 Nov 1;440(4):539-44. doi: 10.1016/j.bbrc.2013.09.099. Epub 2013 Oct 5.
95. PDGFRA, PDGFRB, EGFR, and downstream signaling activation in malignant peripheral nerve sheath tumor. Perrone F, etal., Neuro Oncol. 2009 Dec;11(6):725-36. doi: 10.1215/15228517-2009-003.
96. Comparative genomic and functional analyses reveal a novel cis-acting PTEN regulatory element as a highly conserved functional E-box motif deleted in Cowden syndrome. Pezzolesi MG, etal., Hum Mol Genet. 2007 May 1;16(9):1058-71. Epub 2007 Mar 6.
97. Activation of multiple angiogenic signaling pathways in hemangiopericytoma. Pierscianek D, etal., Brain Tumor Pathol. 2016 Jul;33(3):200-8. doi: 10.1007/s10014-016-0256-6. Epub 2016 Mar 7.
98. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
99. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
100. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
101. The Metabolic Reprogramming Profiles in the Liver Fibrosis of Mice Infected with Schistosoma japonicum. Qian XY, etal., Inflammation. 2020 Apr;43(2):731-743. doi: 10.1007/s10753-019-01160-5.
102. Impact of PTEN expression on the outcome of hepatitis C virus-positive cirrhotic hepatocellular carcinoma patients: possible relationship with COX II and inducible nitric oxide synthase. Rahman MA, etal., Int J Cancer. 2002 Jul 10;100(2):152-7. doi: 10.1002/ijc.10458.
103. Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma. Ratnacaram CK, etal., Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2521-6. Epub 2008 Feb 11.
104. GOA pipeline RGD automated data pipeline
105. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
106. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
107. Diabetes alters vascular mechanotransduction: pressure-induced regulation of mitogen activated protein kinases in the rat inferior vena cava. Rice KM, etal., Cardiovasc Diabetol. 2006 Sep 8;5:18.
108. Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity. Riquelme SA, etal., Immunity. 2017 Dec 19;47(6):1169-1181.e7. doi: 10.1016/j.immuni.2017.11.010. Epub 2017 Dec 12.
109. PTEN/MMAC1 mutations in endometrial cancers. Risinger JI, etal., Cancer Res. 1997 Nov 1;57(21):4736-8.
110. Age-dependent expression of Pten and Smad4 genes in the urogenital system of Wistar rats. Rocha BR, etal., Acta Cir Bras. 2014;29 Suppl 1:34-8.
111. Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer. Roseweir AK, etal., Oncotarget. 2016 Oct 25;7(43):70601-70612. doi: 10.18632/oncotarget.12134.
112. Somatic mutations of signaling genes in non-small-cell lung cancer. Sanders HR and Albitar M, Cancer Genet Cytogenet. 2010 Nov;203(1):7-15.
113. Distinct expression profiles for PTEN transcript and its splice variants in Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome. Sarquis MS, etal., Am J Hum Genet. 2006 Jul;79(1):23-30. Epub 2006 May 22.
114. Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. Sato N, etal., Cancer Res. 2000 Dec 15;60(24):7052-6.
115. Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia. Schabbauer G, etal., J Immunol. 2010 Jul 1;185(1):468-76. doi: 10.4049/jimmunol.0902221. Epub 2010 May 26.
116. Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis. Schmitz M, etal., Int J Cancer. 2007 Mar 15;120(6):1284-92.
117. The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. Schwartzbauer G and Robbins J, J Biol Chem. 2001 Sep 21;276(38):35786-93. Epub 2001 Jul 11.
118. AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development. Sellitto C, etal., J Clin Invest. 2013 Dec;123(12):5401-9. doi: 10.1172/JCI70437. Epub 2013 Nov 25.
119. Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. Seqqat R, etal., J Mol Cell Cardiol. 2012 Aug;53(2):240-9. doi: 10.1016/j.yjmcc.2012.05.004. Epub 2012 May 15.
120. MicroRNA-21/PTEN/Akt axis in the fibrogenesis of biliary atresia. Shen W, etal., J Pediatr Surg. 2014 Dec;49(12):1738-41. doi: 10.1016/j.jpedsurg.2014.09.009. Epub 2014 Nov 13.
121. ER stress in retinal degeneration in S334ter Rho rats. Shinde VM, etal., PLoS One. 2012;7(3):e33266. doi: 10.1371/journal.pone.0033266. Epub 2012 Mar 14.
122. Human Ia antigens--purification and molecular structure. Snary D, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:379-86.
123. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Steck PA, etal., Nat Genet. 1997 Apr;15(4):356-62.
124. The involvement of PTEN in sleep deprivation-induced memory impairment in rats. Su CL, etal., Mol Pharmacol. 2004 Nov;66(5):1340-8. Epub 2004 Aug 18.
125. In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis. Su Y, etal., Carcinogenesis. 2007 May;28(5):1046-51. Epub 2006 Dec 13.
126. Hepatitis B virus-triggered PTEN/β-catenin/c-Myc signaling enhances PD-L1 expression to promote immune evasion. Sun Y, etal., Am J Physiol Gastrointest Liver Physiol. 2020 Jan 1;318(1):G162-G173. doi: 10.1152/ajpgi.00197.2019. Epub 2019 Oct 11.
127. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
128. Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice. Takei Y, etal., Mol Cancer Ther. 2008 Mar;7(3):704-11. doi: 10.1158/1535-7163.MCT-06-0724.
129. Aging gastropathy-novel mechanisms: hypoxia, up-regulation of multifunctional phosphatase PTEN, and proapoptotic factors. Tarnawski A, etal., Gastroenterology. 2007 Dec;133(6):1938-47. Epub 2007 Aug 21.
130. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
131. The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases. Tsou HC, etal., Am J Hum Genet. 1997 Nov;61(5):1036-43.
132. Abnormal PTEN expression in portal hypertensive gastric mucosa: a key to impaired PI 3-kinase/Akt activation and delayed injury healing? Tsugawa K, etal., FASEB J. 2003 Dec;17(15):2316-8. Epub 2003 Oct 2.
133. Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi T, etal., Cancer Lett 2001 Jan 26;162(2):207-11.
134. Hepatitis B virus x protein accelerated the proliferation of hepatocellular carcinoma cell through lncRNA SNHG20/PTEN pathway. Tu W, etal., J Biochem. 2019 May 1;165(5):423-431. doi: 10.1093/jb/mvy120.
135. PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism. Vinciguerra M, etal., Gastroenterology. 2008 Jan;134(1):268-80. Epub 2007 Oct 10.
136. Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma. Wang X, etal., Oncogene. 2020 Oct;39(40):6286-6299. doi: 10.1038/s41388-020-01434-5. Epub 2020 Aug 25.
137. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
138. PDZ domains of Par-3 as potential phosphoinositide signaling integrators. Wu H, etal., Mol Cell. 2007 Dec 14;28(5):886-98.
139. MicroRNA-494-3p protects rat cardiomyocytes against septic shock via PTEN. Wu P, etal., Exp Ther Med. 2019 Mar;17(3):1706-1716. doi: 10.3892/etm.2018.7116. Epub 2018 Dec 19.
140. The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress. Wu Q, etal., Front Mol Neurosci. 2016 Dec 8;9:140. doi: 10.3389/fnmol.2016.00140. eCollection 2016.
141. Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. Wu R, etal., Cancer Cell. 2007 Apr;11(4):321-33.
142. Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells. Wu W, etal., J Biol Chem 2003 Jul 25;278(30):28258-63. Epub 2003 May 12.
143. Zhonghua xin xue guan bing za zhi Wu Y and Hu YE, Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Mar;33(3):265-8.
144. MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer. Wu YR, etal., Tumour Biol. 2016 Sep;37(9):12061-12070. doi: 10.1007/s13277-016-5074-2. Epub 2016 May 17.
145. PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation. Xiao Y, etal., Cell Signal. 2007 Jul;19(7):1434-45. Epub 2007 Jan 25.
146. PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN. Xiong J, etal., Oncol Rep. 2016 Oct;36(4):1819-28. doi: 10.3892/or.2016.5030. Epub 2016 Aug 23.
147. Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase. Xu J, etal., J Biol Chem. 2003 Jul 18;278(29):26929-37. Epub 2003 Apr 16.
148. Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway. Xu Z, etal., Exp Mol Med. 2018 Jan 5;50(1):e417. doi: 10.1038/emm.2017.158.
149. PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress. Yang G, etal., Development. 2008 Nov;135(21):3587-97. doi: 10.1242/dev.028118. Epub 2008 Oct 2.
150. MicroRNA-214 Inhibits Left Ventricular Remodeling in an Acute Myocardial Infarction Rat Model by Suppressing Cellular Apoptosis via the Phosphatase and Tensin Homolog (PTEN). Yang X, etal., Int Heart J. 2016;57(2):247-50. doi: 10.1536/ihj.15-293. Epub 2016 Mar 11.
151. Phosphorylation and inactivation of PTEN at residues Ser380/Thr382/383 induced by Helicobacter pylori promotes gastric epithelial cell survival through PI3K/Akt pathway. Yang Z, etal., Oncotarget. 2015 Oct 13;6(31):31916-26. doi: 10.18632/oncotarget.5577.
152. Hepatic insulin resistance induced by prenatal alcohol exposure is associated with reduced PTEN and TRB3 acetylation in adult rat offspring. Yao XH and Nyomba BL, Am J Physiol Regul Integr Comp Physiol. 2008 Apr 2;.
153. Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver. Yeon JE, etal., Hepatology 2003 Sep;38(3):703-14.
154. FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome. Yoshimoto M, etal., Br J Cancer. 2007 Sep 3;97(5):678-85. Epub 2007 Aug 14.
155. MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). Zhang JG, etal., Clin Chim Acta. 2010 Jun 3;411(11-12):846-52. doi: 10.1016/j.cca.2010.02.074. Epub 2010 Mar 16.
156. Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury. Zhang QG, etal., FEBS Lett. 2007 Feb 6;581(3):495-505. Epub 2007 Jan 16.
157. [Expression and significance of P16INK4A and PTEN in high-risk human papillomavirus-related cervical cancer] Zhao XL, etal., Ai Zheng. 2007 May;26(5):480-3.
158. microRNA-222 targeting PTEN promotes neurite outgrowth from adult dorsal root ganglion neurons following sciatic nerve transection. Zhou S, etal., PLoS One. 2012;7(9):e44768. doi: 10.1371/journal.pone.0044768. Epub 2012 Sep 13.
159. The adenovirus-mediated transfer of PTEN inhibits the growth of esophageal cancer cells in vitro and in vivo. Zhou YA, etal., Biosci Biotechnol Biochem. 2010;74(4):736-40. doi: 10.1271/bbb.90787. Epub 2010 Apr 7.
160. [PTEN negatively regulates isoproterenol-induced cardiac hypertrophy and effects of captopril on PTEN expression] Zhou YZ, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Aug;33(8):738-42.
161. MicroRNA-494 improves functional recovery and inhibits apoptosis by modulating PTEN/AKT/mTOR pathway in rats after spinal cord injury. Zhu H, etal., Biomed Pharmacother. 2017 Aug;92:879-887. doi: 10.1016/j.biopha.2017.05.143. Epub 2017 Jun 7.
162. PTEN and VEGF: possible predictors for sentinel lymph node micro-metastasis in breast cancer. Zhu L, etal., Biomed Pharmacother. 2007 Oct;61(9):558-61. Epub 2007 Sep 17.
163. PTEN: a crucial mediator of mitochondria-dependent apoptosis. Zhu Y, etal., Apoptosis. 2006 Feb;11(2):197-207.
164. Phosphatase and tensin homolog in cerebral cavernous malformation: a potential role in pathological angiogenesis. Zhu Y, etal., J Neurosurg. 2009 Mar;110(3):530-9. doi: 10.3171/2008.7.17626.
165. PTEN inhibitors cause a negative inotropic and chronotropic effect in mice. Zu L, etal., Eur J Pharmacol. 2011 Jan 10;650(1):298-302. doi: 10.1016/j.ejphar.2010.09.069. Epub 2010 Oct 14.
Additional References at PubMed
PMID:9187108   PMID:9256433   PMID:9593664   PMID:9616126   PMID:9778245   PMID:9811831   PMID:9990064   PMID:10339565   PMID:10468583   PMID:10646847   PMID:10760291   PMID:10866658  
PMID:10918569   PMID:10940933   PMID:12091320   PMID:12461751   PMID:14522255   PMID:15755804   PMID:15968641   PMID:15994948   PMID:16027168   PMID:16027169   PMID:16107612   PMID:16675393  
PMID:16762504   PMID:16821090   PMID:16845383   PMID:16951163   PMID:17218261   PMID:17706614   PMID:17880912   PMID:17893321   PMID:18082964   PMID:18332125   PMID:18562292   PMID:18586681  
PMID:18931933   PMID:18983770   PMID:19057511   PMID:19080402   PMID:19114034   PMID:19142997   PMID:19147652   PMID:19208814   PMID:19276401   PMID:19309364   PMID:19436944   PMID:19553907  
PMID:19623194   PMID:19703128   PMID:19778506   PMID:19778579   PMID:20051384   PMID:20100827   PMID:20123964   PMID:20237282   PMID:20347952   PMID:20360540   PMID:20448149   PMID:20610402  
PMID:20610765   PMID:20730910   PMID:20815283   PMID:20830745   PMID:20940307   PMID:21084616   PMID:21162269   PMID:21166162   PMID:21185267   PMID:21189582   PMID:21241890   PMID:21266327  
PMID:21411674   PMID:21529704   PMID:21573166   PMID:21618527   PMID:21664258   PMID:21828076   PMID:21861051   PMID:21940949   PMID:22205501   PMID:22301622   PMID:22317922   PMID:22413754  
PMID:22561258   PMID:22687987   PMID:22735908   PMID:22746319   PMID:22841775   PMID:22879939   PMID:22887358   PMID:23041795   PMID:23399867   PMID:23524257   PMID:23533567   PMID:23575307  
PMID:23637190   PMID:23686705   PMID:23726960   PMID:23783805   PMID:23799014   PMID:23904244   PMID:23978520   PMID:24297385   PMID:24676391   PMID:24680972   PMID:24733831   PMID:24766807  
PMID:24824654   PMID:24862762   PMID:24875179   PMID:25007873   PMID:25057197   PMID:25335889   PMID:25512490   PMID:25665754   PMID:25787292   PMID:25871970   PMID:25889774   PMID:25918024  
PMID:26130252   PMID:26203138   PMID:26208095   PMID:26228367   PMID:26232589   PMID:26280536   PMID:26296331   PMID:26299948   PMID:26415649   PMID:26471078   PMID:26541756   PMID:26591002  
PMID:26609164   PMID:26660904   PMID:26674985   PMID:27230112   PMID:27297622   PMID:27391443   PMID:27708252   PMID:27747225   PMID:27836791   PMID:27919618   PMID:28063931   PMID:28281184  
PMID:28374893   PMID:28542730   PMID:28601397   PMID:28695481   PMID:28701356   PMID:28807003   PMID:28842516   PMID:28925480   PMID:29305963   PMID:29440462   PMID:29454667   PMID:29506055  
PMID:29566365   PMID:29649487   PMID:30030400   PMID:30267829   PMID:30321515   PMID:30368869   PMID:30654931   PMID:31088038   PMID:31091855   PMID:31106896   PMID:31120592   PMID:31144461  
PMID:31432320   PMID:31454541   PMID:31537899   PMID:31557405   PMID:31702028   PMID:31814541   PMID:31837294   PMID:31842626   PMID:31858563   PMID:32037610   PMID:32052426   PMID:32495857  
PMID:32591959   PMID:32819563   PMID:32888649   PMID:33180227   PMID:33188203   PMID:33456568   PMID:33652126   PMID:33712741   PMID:33730297   PMID:33777313   PMID:34080640   PMID:34218417  
PMID:34435045   PMID:34506261   PMID:34633595   PMID:35012910   PMID:35034538   PMID:35121403   PMID:35152668   PMID:35436530   PMID:35717938   PMID:35878435   PMID:35985997   PMID:37057740  
PMID:37066940   PMID:37084543   PMID:37178238   PMID:37393018   PMID:37589761   PMID:38092760   PMID:38279488   PMID:38508437  


Genomics

Comparative Map Data
Pten
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,043,707 - 240,110,330 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1240,043,707 - 240,110,330 (+)EnsemblGRCr8
mRatBN7.21230,630,443 - 230,697,070 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1230,630,338 - 230,696,838 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1239,010,509 - 239,075,549 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01245,940,213 - 246,005,253 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01238,778,317 - 238,843,363 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,421,814 - 251,487,634 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,421,596 - 251,487,832 (+)Ensemblrn6Rnor6.0
Rnor_5.01258,651,829 - 258,717,009 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41236,771,027 - 236,837,261 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1227,746,622 - 227,812,108 (+)NCBICelera
RGSC_v3.11236,935,049 - 237,001,284 (+)NCBI
Cytogenetic Map1q52NCBI
PTEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381087,863,625 - 87,971,930 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1087,862,638 - 87,971,930 (+)Ensemblhg38GRCh38
GRCh371089,623,382 - 89,731,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361089,613,175 - 89,718,512 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341089,613,174 - 89,716,382NCBI
Celera1083,369,676 - 83,474,975 (+)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1083,258,013 - 83,363,313 (+)NCBIHuRef
CHM1_11089,905,493 - 90,010,826 (+)NCBICHM1_1
T2T-CHM13v2.01088,747,528 - 88,855,830 (+)NCBIT2T-CHM13v2.0
Pten
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391932,734,977 - 32,803,560 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1932,734,897 - 32,803,560 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381932,757,577 - 32,826,160 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1932,757,497 - 32,826,160 (+)Ensemblmm10GRCm38
MGSCv371932,832,067 - 32,900,650 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361932,823,574 - 32,892,157 (+)NCBIMGSCv36mm8
Celera1933,541,182 - 33,610,051 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1928.14NCBI
Pten
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554255,014,147 - 5,091,829 (-)Ensembl
ChiLan1.0NW_0049554255,007,811 - 5,091,829 (-)NCBIChiLan1.0ChiLan1.0
PTEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2899,880,836 - 99,988,640 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11099,886,147 - 99,990,806 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01084,587,841 - 84,689,043 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11088,093,539 - 88,197,902 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1088,093,539 - 88,194,605 (+)EnsemblpanPan2panpan1.1
PTEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12637,853,148 - 37,913,176 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2637,835,661 - 37,913,176 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2637,711,222 - 37,730,964 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02639,359,420 - 39,447,205 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2639,359,407 - 39,447,189 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12637,265,630 - 37,349,813 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02636,847,668 - 36,931,645 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02638,118,261 - 38,202,372 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pten
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721377,454,602 - 77,542,975 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367351,252,414 - 1,338,323 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367351,252,414 - 1,338,318 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11499,929,590 - 100,021,619 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214108,911,519 - 109,003,081 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTEN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1981,308,058 - 81,412,386 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl981,309,099 - 81,409,146 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604841,972,612 - 42,077,014 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pten
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479113,975,235 - 14,056,900 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pten
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1232,794,056 - 32,865,407 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pten
288 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir21rno-miR-21-5pMirtarbaseexternal_infoMicroarray//qRT-PCR//Western blotFunctional MTI17478730

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:60
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000028143
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat


Genetic Models
This gene Pten is modified in the following models/strains:
SD-Ptenem1Sage    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028143   ⟹   ENSRNOP00000028143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,043,707 - 240,110,330 (+)Ensembl
mRatBN7.2 Ensembl1230,630,338 - 230,696,838 (+)Ensembl
Rnor_6.0 Ensembl1251,421,596 - 251,487,832 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117228   ⟹   ENSRNOP00000097310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,043,707 - 240,110,330 (+)Ensembl
mRatBN7.2 Ensembl1230,630,338 - 230,696,838 (+)Ensembl
RefSeq Acc Id: NM_031606   ⟹   NP_113794
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,043,707 - 240,110,330 (+)NCBI
mRatBN7.21230,630,443 - 230,697,070 (+)NCBI
Rnor_6.01251,421,814 - 251,487,634 (+)NCBI
Rnor_5.01258,651,829 - 258,717,009 (+)NCBI
RGSC_v3.41236,771,027 - 236,837,261 (+)RGD
Celera1227,746,622 - 227,812,108 (+)RGD
Sequence:
RefSeq Acc Id: NP_113794   ⟸   NM_031606
- UniProtKB: O54857 (UniProtKB/TrEMBL),   A6I112 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028143   ⟸   ENSRNOT00000028143
Ensembl Acc Id: ENSRNOP00000097310   ⟸   ENSRNOT00000117228
Protein Domains
C2 tensin-type   Phosphatase tensin-type   Tyrosine specific protein phosphatases

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54857-F1-model_v2 AlphaFold O54857 1-403 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61995 AgrOrtholog
BioCyc Gene G2FUF-55909 BioCyc
BioCyc Pathway PWY-6368 [3-phosphoinositide degradation] BioCyc
BioCyc Pathway Image PWY-6368 BioCyc
Ensembl Genes ENSRNOG00000020723 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028143.4 UniProtKB/Swiss-Prot
  ENSRNOT00000117228 ENTREZGENE
Gene3D-CATH 2.60.40.1110 UniProtKB/Swiss-Prot
  3.90.190.10 UniProtKB/Swiss-Prot
InterPro Bifunc_PIno_P3_Pase/Pase_PTEN UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  Dual-spec_lipid-protein_phosph UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  PTP_PTEN UniProtKB/Swiss-Prot
  Tensin_C2-dom UniProtKB/Swiss-Prot
  Tensin_phosphatase UniProtKB/Swiss-Prot
  Tyr_Pase_AS UniProtKB/Swiss-Prot
  Tyr_Pase_cat UniProtKB/Swiss-Prot
  Tyr_Pase_dom UniProtKB/Swiss-Prot
KEGG Report rno:50557 UniProtKB/Swiss-Prot
NCBI Gene 50557 ENTREZGENE
PANTHER PHOSPHATASE WITH HOMOLOGY TO TENSIN UniProtKB/Swiss-Prot
  PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN UniProtKB/Swiss-Prot
Pfam PTEN_C2 UniProtKB/Swiss-Prot
  Tc-R-P UniProtKB/Swiss-Prot
PharmGKB PTEN RGD
PhenoGen Pten PhenoGen
PIRSF PTEN UniProtKB/Swiss-Prot
PROSITE C2_TENSIN UniProtKB/Swiss-Prot
  PPASE_TENSIN UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020723 RatGTEx
SMART PTEN_C2 UniProtKB/Swiss-Prot
  PTPc_motif UniProtKB/Swiss-Prot
  PTPlike_phytase UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot
  SSF52799 UniProtKB/Swiss-Prot
TIGR TC218878
UniProt A0A8I6AU71_RAT UniProtKB/TrEMBL
  A6I110_RAT UniProtKB/TrEMBL
  A6I112 ENTREZGENE, UniProtKB/TrEMBL
  O54857 ENTREZGENE, UniProtKB/Swiss-Prot
  Q812B9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pten  phosphatase and tensin homolog       Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression increased liver expression is detected in response to ethanol consumption 1299125
gene_function human homolog dephosphorylates phosphatidylinositol 3,4,5-trisphosphate 70314
gene_function human homolog dephosphorylates phosphatidylinositol 3,4,5-trisphosphate 70315
gene_process may be involved in small cell lung adenocarcinomas, but not in non-small cell lung adenocarcinomas 70314
gene_process may be involved in small cell lung adenocarcinomas, but not in non-small cell lung adenocarcinomas 70315