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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptendecreases phosphorylationEXP 6480464CTDDoxorubicin results in decreased phosphorylation of PTEN proteinPMID:32691977
Ptenmultiple interactionsEXP 6480464CTDplumbagin inhibits the reaction [Doxorubicin results in decreased phosphorylation of PTEN protein]PMID:32691977
Ptenaffects expressionISOPTEN (Homo sapiens)6480464CTDDoxorubicin affects the expression of PTEN mRNAPMID:26969377
Ptenincreases activityISOPTEN (Homo sapiens)6480464CTDDoxorubicin results in increased activity of PTEN proteinPMID:11707646
Ptenincreases response to substanceISOPTEN (Homo sapiens)6480464CTDPTEN protein results in increased susceptibility to Doxorubicin; PTEN results in increased susceptibility to DoxorubicinPMID:15548710 PMID:16438844 PMID:17359293 PMID:17935137 PMID:22185283
Ptenmultiple interactionsISOPTEN (Homo sapiens)6480464CTD[Doxorubicin co-treated with resveratrol] results in increased expression of PTEN mRNA; [Doxorubicin co-treated with trichostatin A] results in increased expression of PTEN mRNA; PTEN protein affects the susceptibility to [Doxorubicin co-treated with trichostatin A]; PTEN protein inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of AKT1 protein]; PTEN protein promotes the reaction [Doxorubicin results in decreased expression of AKT1 protein modified form]; PTEN protein promotes the reaction [Doxorubicin results in decreased expression of BAD protein modified form]; PTEN protein promotes the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]; PTEN protein promotes the reaction [Doxorubicin results in decreased phosphorylation of BAD protein]; wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Doxorubicin]PMID:16438844 PMID:17330857 PMID:17359293 PMID:17935137 PMID:26969377
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