PTEN (phosphatase and tensin homolog) - Rat Genome Database

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Gene: PTEN (phosphatase and tensin homolog) Pan paniscus
Analyze
Symbol: PTEN
Name: phosphatase and tensin homolog
RGD ID: 11834437
Description: This gene encodes a dual-specificity phosphatase that regulates the mitogen activated protein kinase pathway through its phosphatase activity and the phosphatidylinositol 3-kinase pathway through its lipid phosphatase activity. It was first identified because of its tumor suppressor activity, and mutations in this gene are associated with many types of cancers in mouse and human. [provided by RefSeq, May 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: mitochondrial PTENalpha; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2899,880,836 - 99,988,640 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11099,886,147 - 99,990,806 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01084,587,841 - 84,689,043 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11088,093,539 - 88,197,902 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1088,093,539 - 88,194,605 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute megakaryocytic leukemia  (ISO)
acute myocardial infarction  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
angiomyolipoma  (ISO)
anisometropia  (ISO)
asthma  (ISO)
Ataxia  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bacterial pneumonia  (ISO)
Bannayan-Riley-Ruvalcaba syndrome  (ISO)
biliary atresia  (ISO)
bladder squamous cell carcinoma  (ISO)
brain disease  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Cardiovascular Abnormalities  (ISO)
cataract  (ISO)
cerebral cavernous malformation  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chlamydiaceae Infections  (ISO)
cholangiocarcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Hypomyelinating Neuropathy  (ISO)
Cowden syndrome  (ISO)
Cowden syndrome 4  (ISO)
Craniofacial Abnormalities  (ISO)
developmental coordination disorder  (ISO)
Developmental Disabilities  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diffuse large B-cell lymphoma  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Ductal Carcinoma  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
endometrial hyperplasia  (ISO)
Endometrial Intraepithelial Neoplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
epilepsy  (ISO)
Epstein-Barr virus infectious disease  (ISO)
esophageal cancer  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Melanoma  (ISO)
familial meningioma  (ISO)
fetal alcohol spectrum disorder  (ISO)
Follicular Thyroid Cancer  (ISO)
gastric adenocarcinoma  (ISO)
Generalized Epilepsy  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
Helicobacter Infections  (ISO)
hemangioma  (ISO)
hemangiopericytoma  (ISO)
Hemimegalencephaly  (ISO)
hepatitis B  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
Hypertrophy  (ISO)
in situ carcinoma  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
intermediate coronary syndrome  (ISO)
intestinal pseudo-obstruction  (ISO)
Intimal Hyperplasia  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
juvenile polyposis syndrome  (ISO)
Language Development Disorders  (ISO)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (ISO)
leukemia  (ISO)
lipoma  (ISO)
lipomatosis  (ISO)
liver cirrhosis  (ISO)
long QT syndrome  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphoma  (ISO)
Macrocephaly  (ISO)
macrocephaly-autism syndrome  (ISO)
major depressive disorder  (ISO)
melanoma  (ISO)
meningioma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Mouth Neoplasms  (ISO)
Multiple Abnormalities  (ISO)
muscular dystrophy  (ISO)
myeloproliferative neoplasm  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
Nerve Sheath Neoplasms  (ISO)
Nervous System Malformations  (ISO)
Neurodevelopmental Disorders  (ISO)
Noonan syndrome with multiple lentigines  (ISO)
oral squamous cell carcinoma  (ISO)
osteochondrodysplasia  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous carcinoma  (ISO)
pancreatic cancer  (ISO)
papillary tumor of the pineal region  (ISO)
papillomavirus infectious disease  (ISO)
peripheral nervous system neoplasm  (ISO)
persistent fetal circulation syndrome  (ISO)
Pneumococcal Pneumonia  (ISO)
polydactyly  (ISO)
portal hypertension  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostate Cancer, Hereditary, 1  (ISO)
Prostate Cancer, Somatic  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
Proteus syndrome  (ISO)
Pseudomonas Infections  (ISO)
PTEN hamartoma tumor syndrome  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Reperfusion Injury  (ISO)
retinitis pigmentosa  (ISO)
rhabdomyosarcoma  (ISO)
schizophrenia  (ISO)
Septic Peritonitis  (ISO)
Sezary's disease  (ISO)
silicosis  (ISO)
skin disease  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
skin squamous cell carcinoma  (ISO)
Spinal Cord Injuries  (ISO)
sporadic breast cancer  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
stomach disease  (ISO)
substance-related disorder  (ISO)
thyroid gland follicular carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
uterine cancer  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)
uterine corpus cancer  (ISO)
visual epilepsy  (ISO)
X-linked VACTERL association  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (ISO)
angiogenesis  (ISO)
apoptotic process  (IEA,ISO)
B cell proliferation  (ISO)
brain morphogenesis  (ISO)
canonical Wnt signaling pathway  (ISO)
cardiac muscle tissue development  (ISO)
cell migration  (ISO)
cell motility  (IEA)
cell population proliferation  (ISO)
cellular response to decreased oxygen levels  (ISO)
cellular response to electrical stimulus  (ISO)
cellular response to ethanol  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to leptin stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
central nervous system development  (ISO)
central nervous system myelin maintenance  (ISO)
central nervous system neuron axonogenesis  (ISO)
dendritic spine morphogenesis  (ISO)
dentate gyrus development  (ISO)
endothelial cell migration  (ISO)
forebrain morphogenesis  (ISO)
gene expression  (ISO)
heart development  (ISO)
inositol phosphate catabolic process  (ISO)
learning or memory  (ISO)
lipid metabolic process  (IEA)
locomotor rhythm  (ISO)
locomotory behavior  (ISO)
long-term synaptic depression  (ISO)
long-term synaptic potentiation  (ISO)
male mating behavior  (ISO)
maternal behavior  (ISO)
memory  (ISO)
multicellular organismal response to stress  (ISO)
myelination  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of axon regeneration  (ISO)
negative regulation of axonogenesis  (ISO)
negative regulation of B cell proliferation  (ISO)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell cycle G1/S phase transition  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cell size  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of defense response to bacterium  (ISO)
negative regulation of dendrite extension  (ISO)
negative regulation of dendritic spine morphogenesis  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of excitatory postsynaptic potential  (ISO)
negative regulation of focal adhesion assembly  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of keratinocyte migration  (ISO)
negative regulation of myelination  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of organ growth  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of phagocytosis  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of potassium ion transmembrane transporter activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of ribosome biogenesis  (ISO)
negative regulation of signaling receptor activity  (ISO)
negative regulation of synaptic vesicle clustering  (ISO)
negative regulation of T cell proliferation  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of wound healing, spreading of epidermal cells  (ISO)
nervous system development  (IEA)
neuron projection development  (ISO)
neuron-neuron synaptic transmission  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
phosphatidylinositol dephosphorylation  (IEA,ISO)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (ISO)
postsynaptic density assembly  (ISO)
prepulse inhibition  (ISO)
presynaptic membrane assembly  (ISO)
prostate gland growth  (ISO)
protein dephosphorylation  (ISO)
protein stabilization  (ISO)
regulation of axon regeneration  (ISO)
regulation of B cell apoptotic process  (ISO)
regulation of cell cycle  (ISO)
regulation of cellular component size  (ISO)
regulation of cellular localization  (ISO)
regulation of Fc receptor mediated stimulatory signaling pathway  (ISO)
regulation of macrophage apoptotic process  (ISO)
regulation of neuron projection development  (ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
regulation of protein stability  (ISO)
regulation of synaptic transmission, GABAergic  (ISO)
response to activity  (ISO)
response to arsenic-containing substance  (ISO)
response to ATP  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to glucose  (ISO)
response to inorganic substance  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
rhythmic synaptic transmission  (ISO)
social behavior  (ISO)
spindle assembly involved in female meiosis  (ISO)
synapse assembly  (ISO)
synapse maturation  (ISO)
T cell proliferation  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:24768297   PMID:30032202  


Genomics

Comparative Map Data
PTEN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2899,880,836 - 99,988,640 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11099,886,147 - 99,990,806 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01084,587,841 - 84,689,043 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11088,093,539 - 88,197,902 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1088,093,539 - 88,194,605 (+)Ensemblpanpan1.1panPan2
PTEN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381087,863,625 - 87,971,930 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1087,862,638 - 87,971,930 (+)EnsemblGRCh38hg38GRCh38
GRCh371089,623,382 - 89,731,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361089,613,175 - 89,718,512 (+)NCBINCBI36Build 36hg18NCBI36
Build 341089,613,174 - 89,716,382NCBI
Celera1083,369,676 - 83,474,975 (+)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1083,258,013 - 83,363,313 (+)NCBIHuRef
CHM1_11089,905,493 - 90,010,826 (+)NCBICHM1_1
T2T-CHM13v2.01088,747,528 - 88,855,830 (+)NCBIT2T-CHM13v2.0
Pten
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391932,734,977 - 32,803,560 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1932,734,897 - 32,803,560 (+)EnsemblGRCm39 Ensembl
GRCm381932,757,577 - 32,826,160 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1932,757,497 - 32,826,160 (+)EnsemblGRCm38mm10GRCm38
MGSCv371932,832,067 - 32,900,650 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361932,823,574 - 32,892,157 (+)NCBIMGSCv36mm8
Celera1933,541,182 - 33,610,051 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1928.14NCBI
Pten
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,043,707 - 240,110,330 (+)NCBIGRCr8
mRatBN7.21230,630,443 - 230,697,070 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1230,630,338 - 230,696,838 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1239,010,509 - 239,075,549 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01245,940,213 - 246,005,253 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01238,778,317 - 238,843,363 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01251,421,814 - 251,487,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1251,421,596 - 251,487,832 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01258,651,829 - 258,717,009 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,771,027 - 236,837,261 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11236,935,049 - 237,001,284 (+)NCBI
Celera1227,746,622 - 227,812,108 (+)NCBICelera
Cytogenetic Map1q52NCBI
Pten
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554255,014,147 - 5,091,829 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554255,007,811 - 5,091,829 (-)NCBIChiLan1.0ChiLan1.0
PTEN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12637,853,148 - 37,913,176 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2637,835,661 - 37,913,176 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2637,711,222 - 37,730,964 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02639,359,420 - 39,447,205 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2639,359,407 - 39,447,189 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12637,265,630 - 37,349,813 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02636,847,668 - 36,931,645 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02638,118,261 - 38,202,372 (+)NCBIUU_Cfam_GSD_1.0
Pten
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721377,454,602 - 77,542,975 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367351,252,414 - 1,338,323 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367351,252,414 - 1,338,318 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTEN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11499,929,590 - 100,021,619 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214108,911,519 - 109,003,081 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTEN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1981,308,058 - 81,412,386 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl981,309,099 - 81,409,146 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604841,972,612 - 42,077,014 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pten
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479113,975,235 - 14,056,900 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000034900   ⟹   ENSPPAP00000012238
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1088,093,539 - 88,194,605 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000034904   ⟹   ENSPPAP00000012242
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1088,155,078 - 88,194,605 (+)Ensembl
RefSeq Acc Id: NM_001301760   ⟹   NP_001288689
RefSeq Status: REVIEWED
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2899,880,998 - 99,982,186 (+)NCBI
NHGRI_mPanPan11099,886,313 - 99,987,501 (+)NCBI
Mhudiblu_PPA_v01084,587,841 - 84,689,043 (+)NCBI
PanPan1.11088,093,539 - 88,194,605 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055092247   ⟹   XP_054948222
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2899,880,836 - 99,988,640 (+)NCBI
NHGRI_mPanPan11099,886,147 - 99,990,806 (+)NCBI
RefSeq Acc Id: XM_063607188   ⟹   XP_063463258
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2899,889,423 - 99,988,640 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001288689 (Get FASTA)   NCBI Sequence Viewer  
  XP_054948222 (Get FASTA)   NCBI Sequence Viewer  
  XP_063463258 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein DAA64596 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000012238.1
  ENSPPAP00000012242
  ENSPPAP00000012242.1
  ENSPPAP00000033345.1
Reference Protein Sequences
RefSeq Acc Id: NP_001288689   ⟸   NM_001301760
- UniProtKB: A0A2R9BXY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000012242   ⟸   ENSPPAT00000034904
RefSeq Acc Id: ENSPPAP00000012238   ⟸   ENSPPAT00000034900
RefSeq Acc Id: XP_054948222   ⟸   XM_055092247
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063463258   ⟸   XM_063607188
- Peptide Label: isoform X2
Protein Domains
C2 tensin-type   Phosphatase tensin-type   Tyrosine specific protein phosphatases


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029313 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAG00000039531 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000034900.1 UniProtKB/TrEMBL
  ENSPPAT00000034904 ENTREZGENE
  ENSPPAT00000034904.1 UniProtKB/TrEMBL
  ENSPPAT00000056220.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1110 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Bifunc_PIno_P3_Pase/Pase_PTEN UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTP_cat UniProtKB/TrEMBL
  PTP_PTEN UniProtKB/TrEMBL
  Tensin_C2-dom UniProtKB/TrEMBL
  Tensin_phosphatase UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
KEGG Report pps:100983152 UniProtKB/TrEMBL
NCBI Gene PTEN ENTREZGENE
PANTHER PHOSPHATASE WITH HOMOLOGY TO TENSIN UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN UniProtKB/TrEMBL
Pfam PTEN_C2 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PIRSF PTEN UniProtKB/TrEMBL
PROSITE C2_TENSIN UniProtKB/TrEMBL
  PPASE_TENSIN UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
SMART PTEN_C2 UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
  PTPlike_phytase UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt A0A024QYR5_PANPA UniProtKB/TrEMBL
  A0A2R9A4L1_PANPA UniProtKB/TrEMBL
  A0A2R9A4L9_PANPA UniProtKB/TrEMBL
  A0A2R9BXY9 ENTREZGENE, UniProtKB/TrEMBL