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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptendecreases expressionEXP 6480464CTDDiethylnitrosamine results in decreased expression of PTEN protein modified formPMID:19931519
Ptenmultiple interactionsEXP 6480464CTD3,4,5,4'-tetramethoxystilbene affects the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of PTEN mRNA]; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of PTEN mRNA; morin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein modified form]PMID:19931519 PMID:27048571
Ptendecreases expressionISOPten (Mus musculus)6480464CTDDiethylnitrosamine results in decreased expression of PTEN proteinPMID:34726822
Ptenmultiple interactionsISOPten (Mus musculus)6480464CTDmaculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein]; Quercetin inhibits the reaction [Diethylnitrosamine results in decreased expression of PTEN protein]PMID:34726822
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