GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pten | increases response to substance | ISO | PTEN (Homo sapiens) | 6480464 | CTD | PTEN protein results in increased susceptibility to Etoposide | PMID:17935137 | Pten | multiple interactions | ISO | PTEN (Homo sapiens) | 6480464 | CTD | PTEN protein inhibits the reaction [Etoposide results in increased phosphorylation of and results in increased activity of AKT1 protein]; PTEN protein modified form promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; PTEN protein promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; Wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide] | PMID:16807353 PMID:17935137 | | ||||||||||||||||||||||
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