GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pten | decreases expression | ISO | PTEN (Homo sapiens) | 6480464 | CTD | Folic Acid results in decreased expression of PTEN mRNA | PMID:23219837 | Pten | increases methylation | ISO | PTEN (Homo sapiens) | 6480464 | CTD | Folic Acid results in increased methylation of PTEN promoter | PMID:23219837 | Pten | multiple interactions | ISO | Pten (Mus musculus) | 6480464 | CTD | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PTEN mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTEN gene | PMID:20938992 PMID:22206623 | Pten | multiple interactions | ISO | PTEN (Homo sapiens) | 6480464 | CTD | Folic Acid inhibits the reaction [aluminum maltolate results in increased expression of PTEN protein]; MIR19A mRNA affects the reaction [Folic Acid inhibits the reaction [aluminum maltolate results in increased expression of PTEN protein]]; MIR19B1 mRNA affects the reaction [Folic Acid inhibits the reaction [aluminum maltolate results in increased expression of PTEN protein]] | PMID:27113042 | |
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