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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptendecreases expressionISOPTEN (Homo sapiens)6480464CTDFolic Acid results in decreased expression of PTEN mRNAPMID:23219837
Ptenincreases methylationISOPTEN (Homo sapiens)6480464CTDFolic Acid results in increased methylation of PTEN promoterPMID:23219837
Ptenmultiple interactionsISOPten (Mus musculus)6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PTEN mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PTEN genePMID:20938992 PMID:22206623
Ptenmultiple interactionsISOPTEN (Homo sapiens)6480464CTDFolic Acid inhibits the reaction [aluminum maltolate results in increased expression of PTEN protein]; MIR19A mRNA affects the reaction [Folic Acid inhibits the reaction [aluminum maltolate results in increased expression of PTEN protein]]; MIR19B1 mRNA affects the reaction [Folic Acid inhibits the reaction [aluminum maltolate results in increased expression of PTEN protein]]PMID:27113042
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