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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptendecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of PTEN proteinPMID:21195169 PMID:24111524
Ptenmultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein]; celastrol inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein]; PTEN inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein]; PTEN inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein]; PTEN inhibits the reaction [Cadmium Chloride results in increased expression of NCF1 protein]; PTEN inhibits the reaction [Cadmium Chloride results in increased expression of NCF2 protein]; PTEN inhibits the reaction [Cadmium Chloride results in increased expression of NCF4 protein]; PTEN inhibits the reaction [Cadmium Chloride results in increased expression of RAC1 protein]; PTEN protein inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; PTEN protein inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]]; PTEN protein promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]]; Sirolimus inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein]PMID:21195169 PMID:24111524
Ptenaffects expressionISOPten (Mus musculus)6480464CTDCadmium Chloride affects the expression of PTEN mRNAPMID:18974090
Ptendecreases expressionISOPTEN (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of PTEN mRNA; Cadmium Chloride results in decreased expression of PTEN proteinPMID:21195169 PMID:25851441 PMID:27510461 PMID:33129824
Ptendecreases response to substanceISOPTEN (Homo sapiens)6480464CTDPTEN results in decreased susceptibility to Cadmium ChloridePMID:21883094
Ptenincreases phosphorylationISOPTEN (Homo sapiens)6480464CTDCadmium Chloride results in increased phosphorylation of PTEN proteinPMID:34905088
Ptenmultiple interactionsISOPten (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein]; Cadmium Chloride results in increased ubiquitination of and results in increased degradation of and results in decreased expression of PTEN proteinPMID:24449419
Ptenmultiple interactionsISOPTEN (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PTEN protein]; PTEN inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; PTEN inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein]; PTEN inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]PMID:21195169
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