Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptenaffects expressionEXP 6480464CTDDiethylhexyl Phthalate affects the expression of PTEN mRNAPMID:29777495
Ptenmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased expression of PTEN protein; [Plant Extracts co-treated with Diethylhexyl Phthalate] results in decreased expression of PTEN mRNAPMID:29777495 PMID:34910997
Ptenaffects expressionISOPten (Mus musculus)6480464CTDDiethylhexyl Phthalate affects the expression of PTEN mRNAPMID:31211961
Ptendecreases expressionISOPten (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of PTEN mRNA; Diethylhexyl Phthalate results in decreased expression of PTEN proteinPMID:24804967
Ptenincreases expressionISOPTEN (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in increased expression of PTEN proteinPMID:31163220
Ptenmultiple interactionsISOPten (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PTEN mRNAPMID:28433925
Ptenmultiple interactionsISOPTEN (Homo sapiens)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTEN protein]PMID:31163220
Go Back to source page   Continue to Ontology report