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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptenincreases activityISOPTEN (Homo sapiens)6480464CTDCisplatin results in increased activity of PTEN proteinPMID:11707646
Ptenincreases phosphorylationISOPten (Mus musculus)6480464CTDCisplatin results in increased phosphorylation of PTEN proteinPMID:33031932
Ptenincreases response to substanceISOPTEN (Homo sapiens)6480464CTDPTEN results in increased susceptibility to CisplatinPMID:21116717
Ptenmultiple interactionsISOPten (Mus musculus)6480464CTDRutin inhibits the reaction [Cisplatin results in increased phosphorylation of PTEN protein]PMID:33031932
Ptenmultiple interactionsISOPTEN (Homo sapiens)6480464CTD[Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of PTEN mRNA; [MIR21 mRNA results in decreased susceptibility to Cisplatin] which results in decreased expression of PTEN mRNA; [MIR21 mRNA results in decreased susceptibility to Cisplatin] which results in decreased expression of PTEN protein; PTEN protein affects the reaction [Cisplatin results in increased expression of H2AX protein]; PTEN protein affects the reaction [Cisplatin results in increased phosphorylation of ATR protein]; PTEN protein affects the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein]; PTEN protein affects the susceptibility to [Cisplatin co-treated with 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide]PMID:23466500 PMID:30871063 PMID:37802411
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