GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pten | increases activity | ISO | PTEN (Homo sapiens) | 6480464 | CTD | Cisplatin results in increased activity of PTEN protein | PMID:11707646 | Pten | increases phosphorylation | ISO | Pten (Mus musculus) | 6480464 | CTD | Cisplatin results in increased phosphorylation of PTEN protein | PMID:33031932 | Pten | increases response to substance | ISO | PTEN (Homo sapiens) | 6480464 | CTD | PTEN results in increased susceptibility to Cisplatin | PMID:21116717 | Pten | multiple interactions | ISO | Pten (Mus musculus) | 6480464 | CTD | Rutin inhibits the reaction [Cisplatin results in increased phosphorylation of PTEN protein] | PMID:33031932 | Pten | multiple interactions | ISO | PTEN (Homo sapiens) | 6480464 | CTD | [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of PTEN mRNA; [MIR21 mRNA results in decreased susceptibility to Cisplatin] which results in decreased expression of PTEN mRNA; [MIR21 mRNA results in decreased susceptibility to Cisplatin] which results in decreased expression of PTEN protein; PTEN protein affects the reaction [Cisplatin results in increased expression of H2AX protein]; PTEN protein affects the reaction [Cisplatin results in increased phosphorylation of ATR protein]; PTEN protein affects the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein]; PTEN protein affects the susceptibility to [Cisplatin co-treated with 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide] | PMID:23466500 PMID:30871063 PMID:37802411 | |
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